Injectable non-leaching tissue-mimetic bottlebrush elastomers as an advanced platform for reconstructive surgery

Dashtimoghadam, Erfan; Fahimipour, Farahnaz; Keith, Andrew N.; Vashahi, Foad; Popryadukhin, P. V.; Vatankhah-Varnosfaderani, Mohammad; Sheiko, Sergei S.

doi:10.1038/s41467-021-23962-8

Cited by 39 publications

(43 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, brush macromolecules are more compact and less entangled (33)(34)(35)(36)(37), which facilitates injection by reducing solution viscosity compared to linear counterparts of the same molecular weight and concentration (Fig. 1B) (38). Second, grafted side chains, acting as crosslinker diluents, alleviate the need for a large water content to attain the desired gel softness (14).…”

Section: Resultsmentioning

confidence: 99%

Injectable bottlebrush hydrogels with tissue-mimetic mechanical properties

et al. 2022

Self Cite

View full text Add to dashboard Cite

Injectable hydrogels are desired in many biomedical applications due to their minimally invasive deployment to the body and their ability to introduce drugs. However, current injectables suffer from mechanical mismatch with tissue, fragility, water expulsion, and high viscosity. To address these issues, we design brush-like macromolecules that concurrently provide softness, firmness, strength, fluidity, and swellability. The synthesized linear-bottlebrush-linear (LBL) copolymers facilitate improved injectability as the compact conformation of bottlebrush blocks results in low solution viscosity, while the thermoresponsive linear blocks permit prompt gelation at 37°C. The resulting hydrogels mimic the deformation response of supersoft tissues such as adipose and brain while withstanding deformations of 700% and precluding water expulsion upon gelation. Given their low cytotoxicity and mild inflammation in vivo, the developed materials will have vital implications for reconstructive surgery, tissue engineering, and drug delivery applications.

show abstract

Section: Resultsmentioning

confidence: 99%

Injectable bottlebrush hydrogels with tissue-mimetic mechanical properties

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Specific magnetization and coercivity of these MPs are equal to 190 ± 8 emu/g and 9 ± 3 Oe, respectively . Bottlebrushes were synthesized by atom transfer radical copolymerization of PDMS–methacrylate macromonomers ( n sc = 14) and PEG–methacrylate macromonomers ( n sc = 12) with hydroxyl (OH – ) chain ends, which are then cured into elastomers at 60 °C using a di-isocyanate cross-linker (IPDI) (Figures a and S1–S3). The uniformity of PEG incorporation was monitored by NMR (Figure S4).…”

Section: Results and Discussionmentioning

confidence: 99%

Regulating Tissue-Mimetic Mechanical Properties of Bottlebrush Elastomers by Magnetic Field

Kostrov

Dashtimoghadam

Keith

et al. 2021

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

We report on a new class of magnetoactive elastomers (MAEs) based on bottlebrush polymer networks filled with carbonyl iron microparticles. By synergistically combining solvent-free, yet supersoft polymer matrices, with magnetic microparticles, we enable the design of composites that not only mimic the mechanical behavior of various biological tissues but also permit contactless regulation of this behavior by external magnetic fields. While the bottlebrush architecture allows to finely tune the matrix elastic modulus and strain-stiffening, the magnetically aligned microparticles generate a 3-order increase in shear modulus accompanied by a switch from a viscoelastic to elastic regime as evidenced by a ca. 10-fold drop of the damping factor. The developed method for MAE preparation through solvent-free coinjection of bottlebrush melts and magnetic particles provides additional advantages such as injection molding of various shapes and uniform particle distribution within MAE composites. The synergistic combination of bottlebrush network architecture and magnetically responsive microparticles empowers new opportunities in the design of actuators and active vibration insulation systems.

show abstract

“…190 MPB gels can be used as injectable hydrogels for cancer immunochemotherapy 191 or directly injected as nonleaching tissue-mimetic elastomers for reconstructive surgery. 192 MPBs can further be used to yield structural analogues of proteoglycan aggregates, [193][194][195] a key component of cartilage, which may further prove valuable for the tissue engineering field. With shaped nanomaterials an ongoing a focus, strategies to induce and explore size-/shape-changing materials are in demand.…”

Section: Emerging Bio Applications Of Mpbsmentioning

confidence: 99%