Injectable nanofiber-reinforced bone cement with controlled biodegradability for minimally-invasive bone regeneration

Cai, Peihao; Lu, Shunyi; Yu, Jieqin; Xiao, Lan; Wang, Jiayi; Liang, Haifeng; Huang, Lei; Han, Guanjie; Bian, Mengxuan; Zhang, Shihao; Zhang, Jian; Liu, Changsheng; Jiang, Libo; Li, Yulin

doi:10.1016/j.bioactmat.2022.08.009

Cited by 31 publications

(30 citation statements)

References 56 publications

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“…0232-11) and DCPA at 21° and 31° (JCPDS card No. 9-77) as the initial materials (reactants) [ 1 , 31 ]. Progress in the formation of an apatite product after soaking in SBF for 7 days is illustrated in Figure 3 B.…”

Section: Resultsmentioning

confidence: 99%

“…The injectability of the CPCs was performed by a Zwick/Roell-HCR 25/400 mechanical device at a cross-head speed of 5 mm/min [ 1 ]. Two minutes after mixing the cement components, the as-prepared paste was transferred into a 10 mL syringe (inner tip diameter of 800 μm).…”

Section: Methodsmentioning

confidence: 99%

“…Over the past decades, various materials have been applied to repair bone defects and deformities. Apatite-forming calcium phosphate cements (CPCs) have emerged as a highly popular option, particularly for the treatment of osteoporosis-related fractures, craniofacial abnormalities, and deformities, as well as in vertebroplasty procedures [ 1 , 2 , 3 ]. The advantage of CPCs compared to other biomaterials lies in their structural similarity to hydroxyapatite, as well as the mineral component of native bone, which promotes the integration of mineralized tissue and enhances bone repair [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…If they are not properly integrated, the mixture can suffer from decreased injectability and a longer setting time [ 21 ]. In a previous study, it was reported that the strength of CPC was enhanced by adding medical sutures made of polylactic-co-glycolic acid (PLGA), whereas they could not be injected because of long fibers and the lack of integrity [ 1 ]. Additionally, the fiber reinforcement of ceramic materials enhances fracture resistance but simultaneously reduces the strength of the composite [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Reinforcement of Calcium Phosphate Cement with Hybrid Silk Fibroin/Kappa-Carrageenan Nanofibers

et al. 2023

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Calcium phosphate cements (CPCs) offer a promising solution for treating bone defects due to their osteoconductive, injectable, biocompatible, and bone replacement properties. However, their brittle nature restricts their utilization to non-load-bearing applications. In this study, the impact of hybrid silk fibroin (SF) and kappa-carrageenan (k-CG) nanofibers as reinforcements in CPC was investigated. The CPC composite was fabricated by incorporating electrospun nanofibers in 1, 3, and 5% volume fractions. The morphology, mineralization, mechanical properties, setting time, injectability, cell adhesion, and mineralization of the CPC composites were analyzed. The results demonstrated that the addition of the nanofibers improved the CPC mixture, leading to an increase in compressive strength (14.8 ± 0.3 MPa compared to 8.1 ± 0.4 MPa of the unreinforced CPC). Similar improvements were seen in the bending strength and work fracture (WOF). The MC3T3-E1 cell culture experiments indicated that cells attached well to the surfaces of all cement samples and tended to join their adjacent cells. Additionally, the CPC composites showed higher cell mineralization after a culture period of 14 days, indicating that the SF/k-CG combination has potential for applications as a CPC reinforcement and bone cell regeneration promoter.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Reinforcement of Calcium Phosphate Cement with Hybrid Silk Fibroin/Kappa-Carrageenan Nanofibers

et al. 2023

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“…The majority of these procedures have been tested only on murine animal models, including deproteinized bone added with VEGF gene transfer plasmid that provides bone regenerative effects through the enhancement of local angiogenesis, platelet-derived biomaterials endowed with bone healing properties thanks to the migratory ability of embryonic fibroblasts, autologous adipose-derived stem cell-seeded scaffolds that increase femoral strength and bone density in osteoporotic rats, and injectable nano-reinforced bone cement with controlled biodegradability and osteoconductive effect [37][38][39][40] .…”

Section: Bone Augmentation Proceduresmentioning

confidence: 99%

Addressing local bone loss in the proximal femurs of women at high risk of fracture

Paracuollo

Pellegrino

Santulli

et al. 2022

International Journal of Bone Fragility

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Proximal femoral fractures in older women are a worldwide leading cause of morbidity and mortality and a public health problem. Although pharmacological therapies can improve bone mineral density (BMD) and reduce fracture risk, current efforts are focused on researching a procedure that guarantees both immediate and long-lasting effectiveness over time. The AGN1 local osteo-enhancement procedure is a recently developed bone augmentation procedure. This minimally-invasive surgical approach is used to prepare an enhancement site, the area where new bone is desired within a local bony region weakened by osteoporotic bone loss, and fill it with a triphasic, resorbable, calcium-based implant material. This procedure results in a notable, statistically significant and sustained long-term increase in proximal femur BMD and femoral strength, improving femoral neck resistance to compression and distraction forces acting on it and thereby preventing fall-related fractures.

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Tolerant and Rapid Endochondral Bone Regeneration Using Framework‐Enhanced 3D Biomineralized Matrix Hydrogels

Bai,

Liu,

Huang

et al. 2023

Advanced Science

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Tissue‐engineered bone has emerged as a promising alternative for bone defect repair due to the advantages of regenerative bone healing and physiological functional reconstruction. However, there is very limited breakthrough in achieving favorable bone regeneration due to the harsh osteogenic microenvironment after bone injury, especially the avascular and hypoxic conditions. Inspired by the bone developmental mode of endochondral ossification, a novel strategy is proposed for tolerant and rapid endochondral bone regeneration using framework‐enhanced 3D biomineralized matrix hydrogels. First, it is meticulously designed 3D biomimetic hydrogels with both hypoxic and osteoinductive microenvironment, and then integrated 3D‐printed polycaprolactone framework to improve their mechanical strength and structural fidelity. The inherent hypoxic 3D matrix microenvironment effectively activates bone marrow mesenchymal stem cells self‐regulation for early‐stage chondrogenesis via TGFβ/Smad signaling pathway due to the obstacle of aerobic respiration. Meanwhile, the strong biomineralized microenvironment, created by a hybrid formulation of native‐constitute osteogenic inorganic salts, can synergistically regulate both bone mineralization and osteoclastic differentiation, and thus accelerate the late‐stage bone maturation. Furthermore, both in vivo ectopic osteogenesis and in situ skull defect repair successfully verified the high efficiency and mechanical maintenance of endochondral bone regeneration mode, which offers a promising treatment for craniofacial bone defect repair.

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Injectable nanofiber-reinforced bone cement with controlled biodegradability for minimally-invasive bone regeneration

Cited by 31 publications

References 56 publications

Reinforcement of Calcium Phosphate Cement with Hybrid Silk Fibroin/Kappa-Carrageenan Nanofibers

Reinforcement of Calcium Phosphate Cement with Hybrid Silk Fibroin/Kappa-Carrageenan Nanofibers

Addressing local bone loss in the proximal femurs of women at high risk of fracture

Tolerant and Rapid Endochondral Bone Regeneration Using Framework‐Enhanced 3D Biomineralized Matrix Hydrogels

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