Injectable methylcellulose hydrogel containing calcium phosphate nanoparticles for bone regeneration

Kim, Min Hee; Kim, Beom Su; Park, Hanna; Lee, Jun; Park, Won Ho

doi:10.1016/j.ijbiomac.2017.12.068

Cited by 75 publications

(37 citation statements)

References 17 publications

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“…Thermo-responsive hydrogels have shown great potential for bone tissue regeneration. Rosuvastatin-loaded chitosan/chondroitin sulfate NPs incorporated into a thermo-sensitive hydrogel provided positive results in vitro [ 143 ] and methylcellulose hydrogel containing bioactive calcium phosphate NPs showed a higher new bone formation in vivo than the pure hydrogel in a rabbit calvaria defect model [ 144 ].…”

Section: Biomedical Applications Of Thermal-nanomaterialsmentioning

confidence: 99%

Thermo-Sensitive Nanomaterials: Recent Advance in Synthesis and Biomedical Applications

et al. 2018

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Progress in nanotechnology has enabled us to open many new fronts in biomedical research by exploiting the peculiar properties of materials at the nanoscale. The thermal sensitivity of certain materials is a highly valuable property because it can be exploited in many promising applications, such as thermo-sensitive drug or gene delivery systems, thermotherapy, thermal biosensors, imaging, and diagnosis. This review focuses on recent advances in thermo-sensitive nanomaterials of interest in biomedical applications. We provide an overview of the different kinds of thermoresponsive nanomaterials, discussing their potential and the physical mechanisms behind their thermal response. We thoroughly review their applications in biomedicine and finally discuss the current challenges and future perspectives of thermal therapies.

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Section: Biomedical Applications Of Thermal-nanomaterialsmentioning

confidence: 99%

Thermo-Sensitive Nanomaterials: Recent Advance in Synthesis and Biomedical Applications

et al. 2018

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“…Studies suggest that silica nanoparticles have intrinsic beneficial biological activity on bone cell (osteoblast and osteoclasts). 21,22 Methylcellulose, 23,24 carboxymethyl cellulose, 25,26 hydroxypropylmethylcellulose, [27][28][29] and silanized-hydroxypropyl methylcellulose [30][31][32] have been reported in the literature to be used with different calcium phosphates to prepare injectable gels for bone tissue engineering applications. This means that cellulose had to be first modified to prepare aforementioned water-soluble cellulose derivatives to be able to form water-based injectable gels.…”

Section: Introductionmentioning

confidence: 99%

Injectable TEMPO-oxidized nanofibrillated cellulose/biphasic calcium phosphate hydrogel for bone regeneration

Safwat

Hassan²,

Saniour

et al. 2018

J Biomater Appl

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Nanofibrillated cellulose, obtained from rice straw agricultural wastes was used as a substrate for the preparation of a new injectable and mineralized hydrogel for bone regeneration. Tetramethyl pyridine oxyl (TEMPO) oxidized nanofibrillated cellulose, was mineralized through the incorporation of a prepared and characterized biphasic calcium phosphate at a fixed ratio of 50 wt%. The TEMPO-oxidized rice straw nanofibrillated cellulose was characterized using transmission electron microscopy, Fourier transform infrared, and carboxylic content determination. The injectability and viscosity of the prepared hydrogel were evaluated using universal testing machine and rheometer testing, respectively. Cytotoxicity and alkaline phosphatase level tests on osteoblast like-cells for in vitro assessment of the biocompatibility were investigated. Results revealed that the isolated rice straw nanofibrillated cellulose is a nanocomposite of the cellulose nanofibers and silica nanoparticles. Rheological properties of the tested materials are suitable for use as injectable material and of nontoxic effect on osteoblast-like cells, as revealed by the positive alkaline phosphate assay. However, nanofibrillated cellulose/ biphasic calcium phosphate hydrogel showed higher cytotoxicity and lower bioactivity test results when compared to that of nanofibrillated cellulose.

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“…The different applications are discussed in this section. as bone [63,64], cartilage [65][66][67], skin [68], nervous system [69][70][71] and cardiac tissue [72][73][74]. Various natural and synthetic biomaterials have been synthesized to this end.…”

Section: Applicationsmentioning

confidence: 99%

Injectable Hydrogels: A Review of Injectability Mechanisms and Biomedical Applications

Mellati

Akhtari

2019

RMM

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Hydrogels have been used for biomedical applications in recent decades. They are a perfect candidate for regenerative medicine as they resemble the extracellular matrix of native tissues. In addition, their highly hydrated structure makes them a suitable choice for drug and other therapeutics delivery. Injectable hydrogels have increasingly gained attention due to their capability for homogeneous mixing with cells and therapeutic agents, minimally invasive administration, and perfect defect filling. In this review, we discuss various mechanisms which facilitate injectability of hydrogels, including in situ gelling liquids, injectable gels, and injectable particles. Then, we explore the biomedical applications of injectable hydrogels, including tissue engineering, therapeutic agent delivery, and medical devices.

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Injectable methylcellulose hydrogel containing calcium phosphate nanoparticles for bone regeneration

Cited by 75 publications

References 17 publications

Thermo-Sensitive Nanomaterials: Recent Advance in Synthesis and Biomedical Applications

Thermo-Sensitive Nanomaterials: Recent Advance in Synthesis and Biomedical Applications

Injectable TEMPO-oxidized nanofibrillated cellulose/biphasic calcium phosphate hydrogel for bone regeneration

Injectable Hydrogels: A Review of Injectability Mechanisms and Biomedical Applications

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