Injectable mesoporous bioactive nanoparticles regenerate bone tissue under osteoporosis conditions

Arcos, Daniel; Gómez-Cerezo, N.; Saiz‐Pardo, Melchor; Pablo, D. de; Ortega, Luís; Enciso, Silvia; Fernández-Tomé, Blanca; Dı́az-Güemes, Idoia; Sánchez-Margallo, Francisco M.; Casarrubios, Laura; Feito, María José; Portolés, María Teresa; Vallet‐Regí, María

doi:10.1016/j.actbio.2022.07.067

Cited by 15 publications

(11 citation statements)

References 62 publications

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“…A composite hydrogel composed of mesoporous bioactive glass achieved differentiated delivery modes for osteogenic recombinant human bone morphogenetic protein-2 and angiogenic vascular endothelial growth factor [ 85 ] and promoted osteogenic differentiation of primary mouse bone marrow stromal stem cells and angiogenesis [ 86 ]. More than that, a mesoporous bioactive glass-loaded composite hydrogel improved bone regeneration in some extreme conditions, such as osteoporosis [ 87 ], oxidative stress [ 88 ], and tumor microenvironments [ 89 ].…”

Section: Classification Of Mesoporous Material-loaded Composite Hydro...mentioning

confidence: 99%

Mesoporous Materials Make Hydrogels More Powerful in Biomedicine

Chen

Qiu

Xia

et al. 2023

Gels

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Scientists have been attempting to improve the properties of mesoporous materials and expand their application since the 1990s, and the combination with hydrogels, macromolecular biological materials, is one of the research focuses currently. Uniform mesoporous structure, high specific surface area, good biocompatibility, and biodegradability make the combined use of mesoporous materials more suitable for the sustained release of loaded drugs than single hydrogels. As a joint result, they can achieve tumor targeting, tumor environment stimulation responsiveness, and multiple therapeutic platforms such as photothermal therapy and photodynamic therapy. Due to the photothermal conversion ability, mesoporous materials can significantly improve the antibacterial ability of hydrogels and offer a novel photocatalytic antibacterial mode. In bone repair systems, mesoporous materials remarkably strengthen the mineralization and mechanical properties of hydrogels, aside from being used as drug carriers to load and release various bioactivators to promote osteogenesis. In hemostasis, mesoporous materials greatly elevate the water absorption rate of hydrogels, enhance the mechanical strength of the blood clot, and dramatically shorten the bleeding time. As for wound healing and tissue regeneration, incorporating mesoporous materials can be promising for enhancing vessel formation and cell proliferation of hydrogels. In this paper, we introduce the classification and preparation methods of mesoporous material-loaded composite hydrogels and highlight the applications of composite hydrogels in drug delivery, tumor therapy, antibacterial treatment, osteogenesis, hemostasis, and wound healing. We also summarize the latest research progress and point out future research directions. After searching, no research reporting these contents was found.

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Section: Classification Of Mesoporous Material-loaded Composite Hydro...mentioning

confidence: 99%

Mesoporous Materials Make Hydrogels More Powerful in Biomedicine

Chen

Qiu

Xia

et al. 2023

Gels

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“…Pontremoli et al reported the use of MBGNs embedded into hydrogels as injectable platforms for the in situ delivery of therapeutic ions [ 140 ]. This strategy has very recently allowed us to deliver MBGNs as intraosseous biomaterials via minimally invasive surgery in an osteoporotic animal model to evaluate the bone regenerative capability of both MBGNs and MBGNs loaded with ipriflavone as an anti-osteoporotic drug (MBGN/IPs) [ 141 ]. Previously, our research group had widely studied the in vitro specific cell responses to MBGNs and MBGN/IPs with cell types involved in bone remodeling, osteogenesis, angiogenesis, and immune response, evidencing the high potential of these nanoparticles for use as drug delivery systems in bone repair and osteoporosis treatments [ 23 , 121 , 125 ].…”

Section: In Vivo Studiesmentioning

confidence: 99%

“…Thus, MBNPs promoted bone regeneration with a moderate inflammatory response, as histological analyses have evidenced. On the other hand, MBGN/IPs produced a higher presence of osteoblasts and enhanced angiogenesis at the defect site, but without showing significant differences in terms of new bone formation [ 141 ].…”

Section: In Vivo Studiesmentioning

confidence: 99%

Mesoporous Bioactive Nanoparticles for Bone Tissue Applications

Arcos

Portolés

2023

IJMS

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Research in nanomaterials with applications in bone regeneration therapies has experienced a very significant advance with the development of bioactive mesoporous nanoparticles (MBNPs). These nanomaterials consist of small spherical particles that exhibit chemical properties and porous structures that stimulate bone tissue regeneration, since they have a composition similar to that of conventional sol–gel bioactive glasses and high specific surface area and porosity values. The rational design of mesoporosity and their ability to incorporate drugs make MBNPs an excellent tool for the treatment of bone defects, as well as the pathologies that cause them, such as osteoporosis, bone cancer, and infection, among others. Moreover, the small size of MBNPs allows them to penetrate inside the cells, provoking specific cellular responses that conventional bone grafts cannot perform. In this review, different aspects of MBNPs are comprehensively collected and discussed, including synthesis strategies, behavior as drug delivery systems, incorporation of therapeutic ions, formation of composites, specific cellular response and, finally, in vivo studies that have been performed to date.

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“…Although mesoporous bioactive materials are not yet in routine clinical use, they have emerged as effective preclinical strategies for bone regeneration. For example, the high osteogenic capability of mesoporous bioactive nanoparticles has been demonstrated in an osteoporotic rabbit model [ 46 ] . Novel biomaterial developments are needed to further improve 3DP scaffold systems so that the 328 simultaneous requirements for mechanical and bioactive properties to induce successful bone healing can be met.…”

Section: 22 3dp Materialsmentioning

confidence: 99%

Research landscape of 3D printing in bone regeneration and bone repair: A bibliometric and visualized analysis from 2012 to 2022

Zhang¹,

Li²,

Lin³

et al. 2023

IJB

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Three-dimensional printing (3DP) is a popular manufacturing technique with versatile potential for materials processing in tissue engineering and regenerative medicine. In particular, the repair and regeneration of significant bone defects remain as substantial clinical challenges that require biomaterial implants to maintain mechanical strength and porosity, which may be realized using 3DP. The rapid progress in 3DP development in the past decade warrants a bibliometric analysis to gain insights into its applications in bone tissue engineering (BTE). Here, we performed a comparative study using bibliometric methods for 3DP in bone repair and regeneration. A total of 2,025 articles were included, and the results showed an increase in the number of publications and relative research interest on 3DP annually worldwide. China was the leader in international cooperation in this field and also the largest contributor to the number of citations. The majority of articles in this field were published in the journal Biofabrication. Chen Y was the author who made the highest contribution to the included studies. The keywords included in the publications were mainly related to BTE and regenerative medicine (including “3DP techniques,” “3DP materials,” “bone regeneration strategies,” and “bone disease therapeutics”) for bone regeneration and repair. This bibliometric and visualized analysis provides significant insights into the historical development of 3DP in BTE from 2012 to 2022, which will be beneficial for scientists to conduct further investigations into this dynamic field.

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Injectable mesoporous bioactive nanoparticles regenerate bone tissue under osteoporosis conditions

Cited by 15 publications

References 62 publications

Mesoporous Materials Make Hydrogels More Powerful in Biomedicine

Mesoporous Materials Make Hydrogels More Powerful in Biomedicine

Mesoporous Bioactive Nanoparticles for Bone Tissue Applications

Research landscape of 3D printing in bone regeneration and bone repair: A bibliometric and visualized analysis from 2012 to 2022

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