Injectable &lt;i&gt;In Situ&lt;/i&gt; Forming Microparticles: A Novel Drug Delivery System

Yapar, Evren Alğın; Inal, Ozge; Özkan, Yalçın; Baykara, Tamer

doi:10.4314/tjpr.v11i2.19

Cited by 29 publications

(7 citation statements)

References 26 publications

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“…As shown in Table , both solvents are liquid at room temperatures (24°C) and in the release media (37°C) …”

Section: Resultsmentioning

confidence: 99%

“…This method is based on different mathematical models, which describe the dissolution profile. The suitable kinetic model was selected according to higher coefficient ( R 2 ) and lower residual mean square criteria . As demonstrated in Table , the kinetics of drug from all formulations except 21B, which contained 67% NMP and free base vancomycin, can be described by Peppas–Sahlin model.…”

Section: Resultsmentioning

confidence: 99%

“…Solvents such as N ‐methyl‐2‐pyrrolidone (NMP) and dimethyl sulfoxide are among the most widely used solvents in these systems. The tendency toward the use of a combination of solvents in formulations to achieve an optimum solvent system for controlling the amount of released drug can be clearly seen in the literature …”

Section: Introductionmentioning

confidence: 97%

“…Several parameters such as solvent, polymer type and its concentration, drug type and its loading could affect the release profile of drug from in situ implants formed by phase inversion . Despite numerous studies in this field, finding a good solvent for controlling the drug release in sustained release drug delivery systems still remains a challenge . Some properties of the solvent in the formulation of in situ forming implants (ISI) like polymer solubility, toxicity, biocompatibility, viscosity, water miscibility, etc.…”

Section: Introductionmentioning

confidence: 99%

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The effect of solvent composition on vancomycin hydrochloride and free base vancomycin release fromin situforming implants

Darestani-Farahani

Vasheghani‐Farahani

Mobedi

et al. 2016

Polym. Adv. Technol.

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In situ forming drug delivery systems that are formed by solvent‐induced phase inversion have attracted extensive attention in sustained delivery of peptides and proteins. Based on the findings of our previous studies, N‐methyl‐2‐pyrrolidone (NMP) and acetone are two solvents that could improve the release profile of vancomycin from in situ forming systems based on poly(D,L‐lactide‐co‐glycolic acid). In this study, the effect of different compositions of these solvents on the release profile of hydrochloride and free base forms of vancomycin was investigated. To this end, several formulations with vancomycin (either hydrochloride or free base form) and different proportions of NMP and acetone were prepared. The cumulative drug release at specified time was determined and tested against conventional kinetic models. The surface and cross‐sectional morphology of implants were investigated by SEM. The experimental results showed that as solvent composition changed, the amount of vancomycin release during the first 12 h changed, too. The use of free base vancomycin resulted in an extended vancomycin release profile with less initial burst release. The formulation containing free base vancomycin and mixed solvents of acetone and NMP in 2:1 ratio released 70% of loaded drug in 6 weeks with near zero‐order kinetic. The best kinetic model to fit the in vitro release profiles was found to be Peppas–Sahlin model. Copyright © 2016 John Wiley & Sons, Ltd.

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“…As shown in Table , both solvents are liquid at room temperatures (24°C) and in the release media (37°C) …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The effect of solvent composition on vancomycin hydrochloride and free base vancomycin release fromin situforming implants

Darestani-Farahani

Vasheghani‐Farahani

Mobedi

et al. 2016

Polym. Adv. Technol.

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“…Higher viscosity of external oil phase, faster emulsification rate and internal: external phase ratio can also contribute to burst reduction. 8,9…”

Section: Introductionmentioning

confidence: 99%

Development and Evaluation of Biodegradable Polymeric Based Long Acting In situ Forming Microparticles of LHRH Agonist Goserelin Acetate

Chauhan¹,

Patel²,

Akbari³

et al. 2019

IJPER

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Aim: Goserelin acetate is parenterally administered, a typical LHRH analogue for the treatment of prostate cancer. The objective of present work was to formulate and evaluate long acting in situ forming microparticles of goserelin using PLGA which would extend the drug release. Materials and Methods: PLGA 50:50 were used as the biodegradable polymer, DMSO was as organic solvent and sesame oil was used as dispersion phase. HLB based system was used in present investigation for stabilizing non-aqueous emulsion prior to administration. Emulsifier mixtures of Span 80 and Tween 80 in different combination were prepared to stabilize microemulsion system with required HLB of external oil. Result: Developed microsphere batch E06 was found to be more stable with external phase ratio 2:8 were visualized under an inverted biological microscope. In vitro drug release profile of goserelin acetate was investigated that ISMs were minimized burst effect and release up to 24 days and it was found to be stable after 1 month. The drug release was observed 95.97%, 94.02% and 97.77% after 24 days in the batches A, B and C respectively of emulsion E06. Conclusion: ISMs of goserelin were successfully formulated and could be a potential substitute for a marketed formulation. The developed Biodegradable injectable in-situ microparticles (ISMs) were found to be optimized, formed stable, spherical and non-porous formulation.

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Lipid Based Nanocarriers: Promising Drug Delivery System for Topical Application

Patel

Thakkar

2021

Euro J Lipid Sci & Tech

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Lipid based delivery system is gaining significant attention of researchers working on the development of novel formulations for improved therapeutic efficacy and safety of drugs. Topical drug delivery is needed in treatment of skin, eyes, rectum, vagina disorders and systemic disorders having skin manifestations. Lipid nanocarriers have widespread application in the topical drug delivery due to the biocompatible, biodegradable, nontoxic and nonirritating nature of the lipid. Microemulsion and nanoemulsion contain lipids in the nanosize range which can lead to penetration of drug to the deeper skin layers. Solid lipid nanoparticles and nanolipid carriers act by forming an occlusive layer on the skin leading to increased hydration and penetration of the drug. Vesicular carriers such as liposomes, niosomes, ultradeformable vesicles, cubosomes etc. are also reported to enhance the penetration of the entrapped drugs in deeper layers of skin. These carrier systems are mainly composed of lipids, surfactants, and co‐surfactants which are safe and quite acceptable by regulatory authorities. The present review article focuses on different types of lipid nanocarriers used in topical drug delivery, their advantages and limitations, mechanism of enhanced penetration, work reported in the related literature, characterization tests and their safety and toxicity concerns.

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Injectable <i>In Situ</i> Forming Microparticles: A Novel Drug Delivery System

Abstract: Abstract

Cited by 29 publications

References 26 publications

The effect of solvent composition on vancomycin hydrochloride and free base vancomycin release fromin situforming implants

The effect of solvent composition on vancomycin hydrochloride and free base vancomycin release fromin situforming implants

Development and Evaluation of Biodegradable Polymeric Based Long Acting In situ Forming Microparticles of LHRH Agonist Goserelin Acetate

Lipid Based Nanocarriers: Promising Drug Delivery System for Topical Application

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