Injectable long acting chitosan/tripolyphosphate microspheres for the intra-articular delivery of lornoxicam: Optimization and in vivo evaluation

Abd-Allah, Hend; Kamel, Amany O.; Sammour, Omaima A.

doi:10.1016/j.carbpol.2016.04.096

Cited by 44 publications

(22 citation statements)

References 35 publications

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“…The new conformation of the material (microspheres of chitosan) after the interaction of the two macromolecules increased the energy. An evidence of these electrostatic interactions is the red shifts in the absorption bands [ 57 ].…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Benzyl Acetate Catalyzed by Lipase Immobilized in Nontoxic Chitosan-Polyphosphate Beads

et al. 2017

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Enzymes serve as biocatalysts for innumerable important reactions, however, their application has limitations, which can in many cases be overcome by using appropriate immobilization strategies. Here, a new support for immobilizing enzymes is proposed. This hybrid organic-inorganic support is composed of chitosan—a natural, nontoxic, biodegradable, and edible biopolymer—and sodium polyphosphate as the inorganic component. Lipase B from Candida antarctica (CALB) was immobilized on microspheres by encapsulation using these polymers. The characterization of the composites (by infrared spectroscopy, thermogravimetric analysis, and confocal Raman microscopy) confirmed the hybrid nature of the support, whose external part consisted of polyphosphate and core was composed of chitosan. The immobilized enzyme had the following advantages: possibility of enzyme reuse, easy biocatalyst recovery, increased resistance to variations in temperature (activity declined from 60 °C and the enzyme was inactivated at 80 °C), and increased catalytic activity in the transesterification reactions. The encapsulated enzymes were utilized as biocatalysts for transesterification reactions to produce the compound responsible for the aroma of jasmine.

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Section: Resultsmentioning

confidence: 99%

Synthesis of Benzyl Acetate Catalyzed by Lipase Immobilized in Nontoxic Chitosan-Polyphosphate Beads

et al. 2017

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“…made chitosan/tripolyphosphate (TPP) microspheres, in which TPP was used as an anionic cross-linker (Abd-Allah et al. 2016). The contained lornoxicam was gradually released over 8 days in vitro and retained in joint during the whole period of the study.…”

Section: Drug Delivery Systems For Oa Therapymentioning

confidence: 99%

Biomaterial-engineered intra-articular drug delivery systems for osteoarthritis therapy

et al. 2019

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Osteoarthritis (OA) is a progressive and degenerative disease, which is no longer confined to the elderly. So far, current treatments are limited to symptom relief, and no valid OA disease-modifying drugs are available. Additionally, OA relative joint is challenging for drug delivery, since the drugs experience rapid clearance in joint, showing a poor bioavailability. Existing therapeutic drugs, like non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids, are not conducive for long-term use due to adverse effects. Though supplementations, including chondroitin sulfate and glucosamine, have shown beneficial effects on joint tissues in OA, their therapeutic use is still debatable. New emerging agents, like Kartogenin (KGN) and Interleukin-1 receptor antagonist (IL-1 ra), without a proper formulation, still will not work. Therefore, it is urgent to establish a suitable and efficient drug delivery system for OA therapy. In this review, we pay attention to various types of drug delivery systems and potential therapeutic drugs that may escalate OA treatments.

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“…It has multiple crystal structures, that is, lamellar, cubic and hexagonal (Qian et al, 2015;Mei et al, 2017a). The special structures provide incorporation of drugs with different solubility, including hydrophilic, hydrophobic and amphiphilic molecules (Conn & Drummond, 2013;Rajabalaya et al, 2017) and also tunable release rate (Rizwan & Boyd, 2015;Abd-Allah et al, 2016;Huang & Gui, 2018). LLC exhibits perfect performance on mucosal (Huang et al, 2017), transdermal (Peng et al, 2015;Musa et al, 2017), periodontal (Mei et al, 2017a;Zheng et al, 2018), subcutaneous (Mei et al, 2017b) and other parenteral drug delivery (Wan et al, 2015;Qin et al, 2016), due to its high drug-loading capacity, appropriate viscoelasticity and good biocompatibility (Abd-Allah et al, 2016;Kulkarni & Thareja, 2016).…”

Section: Introductionmentioning

confidence: 99%

Smart phase transformation system based on lyotropic liquid crystalline@hard capsules for sustained release of hydrophilic and hydrophobic drugs

Zhang

Xiao²,

Huang

et al. 2020

Drug Delivery

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Smart phase transformation systems@hard capsule (SPTS@hard capsule) based on lyotropic liquid crystalline (LLC) were developed for oral sustained release in this study. Doxycycline hydrochloride (DOXY) and meloxicam (MLX) were used as hydrophilic and hydrophobic model drug, respectively. Two systems were added with different additives, that is, gelucire 39/01, PEG 1000 and Tween 80 to adjust their melting point and release profiles. The phase transformation of these systems could be triggered by water as well as temperature. They could spontaneously transform into cubic phase or hexagonal phase when coming across with water, to achieve the 24 h sustained release profile. In addition, the obtained systems could switch between semisolid state and liquid state when temperature changed within room temperature and body temperature, which facilitated the phase transformation in gastrointestinal tract and during their encapsulation into hard capsules. LLC-based SPTS@hard capsule revealed potential for the industrialization of its oral administration on account of its drugs accommodation with different solubility, controllable release profile and simple preparation process.

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Injectable long acting chitosan/tripolyphosphate microspheres for the intra-articular delivery of lornoxicam: Optimization and in vivo evaluation

Cited by 44 publications

References 35 publications

Synthesis of Benzyl Acetate Catalyzed by Lipase Immobilized in Nontoxic Chitosan-Polyphosphate Beads

Synthesis of Benzyl Acetate Catalyzed by Lipase Immobilized in Nontoxic Chitosan-Polyphosphate Beads

Biomaterial-engineered intra-articular drug delivery systems for osteoarthritis therapy

Smart phase transformation system based on lyotropic liquid crystalline@hard capsules for sustained release of hydrophilic and hydrophobic drugs

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