Injectable in situ forming microgels of hyaluronic acid-g-polylactic acid for methylprednisolone release

Pitarresi, Giovanna; Palumbo, Fabio Salvatore; Fiorica, Calogero; Calascibetta, Filippo; Stefano, Mauro Di; Giammona, Gaetano

doi:10.1016/j.eurpolymj.2012.12.001

Cited by 14 publications

(7 citation statements)

References 25 publications

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“…The use of PHEA as carriers of drugs and as a starting material for many other biomedical and pharmaceutical applications has already been reported [29,30]. PHEA was linked with polylactic acid (PLA) and subsequently electrospun in a mixture with polycaprolactone (PCL) [31,32]. Scaffolds obtained from the PHEA-PLA/PCL mixture had fibers with diameters from 500 nm to 1 mm, similar to the ECM.…”

Section: Methodsmentioning

confidence: 99%

Electrospun PHEA-PLA/PCL Scaffold for Vascular Regeneration: A Preliminary in Vivo Evaluation

Buscemi

Palumbo

Maffongelli

et al. 2017

Transplantation Proceedings

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Background. There is increasing interest in the development of vessel substitutes, and many studies are currently focusing on the development of biodegradable scaffolds capable of fostering vascular regeneration. We tested a new biocompatible and biodegradable material with mechanical properties similar to those of blood vessels.Methods. The material used comprises a mixture of a,b-poly(N-2-hydroxyethyl)-D,L-aspartamide (PHEA) and polylactic acid (PLA), combined with polycaprolactone (PCL) by means of electrospinning technique. Low-molecular-weight heparin was also linked to the copolymer. A tubular PHEA-PLA/PCL sample was used to create an arteriovenous fistula in a pig model with the use of the external iliac vessels. The flow was assessed by means of Doppler ultrasound examination weekly, and 1 month after the implantation we removed the scaffold for histopathologic evaluation. Results. The implants showed a perfect leak-proof seal and adequate elastic tension to blood pressure. About w3 weeks after the implantation, Doppler examination revealed thrombosis of the graft, so we proceeded to its removal. Histologic examination showed chronic inflammation, with the presence of foreign body cells and marked neovascularization. The material had been largely absorbed, leaving some isolated spot residues. Conclusions. The biocompatibility of PHEA-PLA/PCL and its physical properties make it suitable for the replacement of vessels. In the future, the possibility of functionalizing the material with a variety of molecules, to modulate the inflammatory and coagulative responses, will allow obtaining devices suitable for the replacement of native vessels.

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Section: Methodsmentioning

confidence: 99%

Electrospun PHEA-PLA/PCL Scaffold for Vascular Regeneration: A Preliminary in Vivo Evaluation

Buscemi

Palumbo

Maffongelli

et al. 2017

Transplantation Proceedings

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“…The ability to release methylprednisolone in an exceedingly prolonged way suggests its potential candidate as in situ forming injectable microgels for the treatment of osteoarthritis. [76] Geng et al have developed an in situ forming gel based on sucrose acetate isobutyrate-PLA composite matrix depot for sustained release of Ivermectin. The increased content of solvents significantly reduced the burst release and cumulative release which was found to a minimum in the formulations with NMP.…”

Section: Peg-pcl-pegmentioning

confidence: 99%

Biodegradable Hydrophobic Injectable Polymers for Drug Delivery and Regenerative Medicine

Arun

Ghosh

Domb

2021

Adv Funct Materials

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Biodegradable, hydrophobic, and injectable liquid polymers are capable of achieving the minimally invasive, sustained, and local release of drugs. These hydrophobic injectable polymers also have potential in the area of regenerative medicine where the biomaterial should be stable for a certain period and then degrade to allow the growth of cells/tissues. This review presents exclusive coverage of biocompatible hydrophobic injectable pasty or liquid polymers that can be injected without the use of any solvent for drug delivery, tissue augmentation, and regenerative medicine application. The synthesis methodologies of several major types of hydrophobic pasty polymers used in the biomedical fields and their properties with the foremost criteria to serve as injectable biomaterial for localized drug delivery and regenerative medicine is described. The hydrophobic biodegradable injectable polymers discussed are aliphatic polyesters, polycarbonates and polyanhydrides, prepared from: lactic acid, glycolic acid, caprolactone, aliphatic diols and diacids, hydroxy fatty acids, and triglycerides such as castor oil.

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“…The synthesis of HA-g-PLA copolymer was performed as previously reported [50,51] (Figure 3). Briefly, a low weight-average molecular weight HA (HALMW) was made soluble in organic solvents by transformation to its tetrabutylammonium (TBA) salt.…”

Section: Synthesis Of Dac ® Ha-g-pla Hydrogel Coatingmentioning

confidence: 99%

Hyaluronic-Based Antibacterial Hydrogel Coating for Implantable Biomaterials in Orthopedics and Trauma: From Basic Research to Clinical Applications

Giammona¹,

Pitarresi²,

Salvatore³

et al. 2018

Hydrogels

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Bacterial colonization of implanted biomaterials remains one of the most challenging complications in orthopedics and trauma surgery, with extremely high social and economic costs. Antibacterial coating of implants has been advocated by many experts as a possible solution to reduce the burden of implant-related infection and several different solutions have been proposed in the last decades. However, while most of the investigated technologies have shown their efficacy in vitro and/or in vivo, only few were able to reach the market, due to clinical, industrial, economic and regulatory issues. Hyaluronic acid composites have been previously shown to possess antifouling capabilities and have been used in various clinical settings to reduce bacterial adhesion and mitigate biofilm-related infections. Recently, a fast-resorbable, hyaluronic-based hydrogel coating was developed to protect implanted biomaterials in orthopedics, trauma and maxillofacial surgery. Preclinical and clinical testing did show the safety and efficacy of the device that can be intraoperatively loaded with one or more antibiotics and directly applied by the surgeon to the implant surface, at the time of surgery. Here, we review the current evidence concerning this very first antibacterial coating of implants and outline the economic impact of the possible large-scale application of this technology.

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Injectable in situ forming microgels of hyaluronic acid-g-polylactic acid for methylprednisolone release

Cited by 14 publications

References 25 publications

Electrospun PHEA-PLA/PCL Scaffold for Vascular Regeneration: A Preliminary in Vivo Evaluation

Electrospun PHEA-PLA/PCL Scaffold for Vascular Regeneration: A Preliminary in Vivo Evaluation

Biodegradable Hydrophobic Injectable Polymers for Drug Delivery and Regenerative Medicine

Hyaluronic-Based Antibacterial Hydrogel Coating for Implantable Biomaterials in Orthopedics and Trauma: From Basic Research to Clinical Applications

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