Injectable hydrogels in stroke and spinal cord injury treatment: a review on hydrogel materials, cell–matrix interactions and glial involvement

Lin, Po Hen; Dong, Qi; Chew, Sing Yian

doi:10.1039/d0ma00732c

Cited by 28 publications

(23 citation statements)

References 172 publications

(233 reference statements)

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“…On the other hand, natural polymers are able to provide structures that can stimulate cell response, and are generally less inflammatory and toxic [ 70 ]. Due to their elastic nature, HGs can be injected at the injury site, filling the SCI cavity, where they can release active agents and cells [ 71 , 72 , 73 ]. Furthermore, a promising property of HGs is the possibility of direct in situ gelation.…”

Section: Drug Delivery To the Spinal Cord: The Role Of Biomaterials I...mentioning

confidence: 99%

Biomaterial-Mediated Factor Delivery for Spinal Cord Injury Treatment

et al. 2022

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Spinal cord injury (SCI) is an injurious process that begins with immediate physical damage to the spinal cord and associated tissues during an acute traumatic event. However, the tissue damage expands in both intensity and volume in the subsequent subacute phase. At this stage, numerous events exacerbate the pathological condition, and therein lies the main cause of post-traumatic neural degeneration, which then ends with the chronic phase. In recent years, therapeutic interventions addressing different neurodegenerative mechanisms have been proposed, but have met with limited success when translated into clinical settings. The underlying reasons for this are that the pathogenesis of SCI is a continued multifactorial disease, and the treatment of only one factor is not sufficient to curb neural degeneration and resulting paralysis. Recent advances have led to the development of biomaterials aiming to promote in situ combinatorial strategies using drugs/biomolecules to achieve a maximized multitarget approach. This review provides an overview of single and combinatorial regenerative-factor-based treatments as well as potential delivery options to treat SCIs.

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Section: Drug Delivery To the Spinal Cord: The Role Of Biomaterials I...mentioning

confidence: 99%

Biomaterial-Mediated Factor Delivery for Spinal Cord Injury Treatment

et al. 2022

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“…In simple terms, it is the likelihood of diffusion of higher (than desired) concentration of therapeutic agents at the time of incorporation of hydrogels at specific sites. Although, it can be overcome by cross-linking of therapeutic agents or use of high-affinity ligands, the prediction and design of absolute systems remains a challenge (Soontornworajit et al, 2010;Lin et al, 2021). However, in spite of the above limitations, it is also important to note that biomaterials are the most practical alternatives to existing treatment strategies available for neurological disorders.…”

Section: Limitations and Future Approaches Of Nanomaterials For Central Nervous System Applicationsmentioning

confidence: 99%

Section: Limitations and Future Approaches Of Nanomaterials For Central Nervous System Applicationsmentioning

confidence: 99%

“…These regulatory mechanisms become increasingly uncongenial and further limit the diffusion of foreign agents into the CNS, in cases of traumatic injuries and formed lesion sites during advanced neurological disorders. During stem cell therapy, this results in inadequate cellular integration with host tissues, poor cell survival, and unregulated cellular differentiation ( Tam et al, 2014 ; Liu et al,2021 ). Efforts to treat these disorders with drug delivery systems face issues like the need for high doses of therapeutics to ensure sufficient diffusion through the blood-brain barrier.…”

Section: Introductionmentioning

confidence: 99%

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Perspective Insights to Bio-Nanomaterials for the Treatment of Neurological Disorders

Khan

Rudrapal²,

Bhat

et al. 2021

Front. Bioeng. Biotechnol.

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The significance of biomaterials is well appreciated in nanotechnology, and its use has resulted in major advances in biomedical sciences. Although, currently, very little data is available on the clinical trial studies for treatment of neurological conditions, numerous promising advancements have been reported in drug delivery and regenerative therapies which can be applied in clinical practice. Among the commonly reported biomaterials in literature, the self-assembling peptides and hydrogels have been recognized as the most potential candidate for treatment of common neurological conditions such as Alzheimer’s, Parkinson’s, spinal cord injury, stroke and tumors. The hydrogels, specifically, offer advantages like flexibility and porosity, and mimics the properties of the extracellular matrix of the central nervous system. These factors make them an ideal scaffold for drug delivery through the blood-brain barrier and tissue regeneration (using stem cells). Thus, the use of biomaterials as suitable matrix for therapeutic purposes has emerged as a promising area of neurosciences. In this review, we describe the application of biomaterials, and the current advances, in treatment of statistically common neurological disorders.

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“…Multifunctional scaffolds can carry the transplanted cells and therapeutic molecules in neural tissue engineering (NTE) (13). The combination of cellular and molecular therapies and scaffold materials has to be considered to overcome the challenges faced in central nervous system (CNS) tissue regeneration (10,14).…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Regenerative Effect of Adipose Tissue Mesenchymal Stem Cell Encapsulated into Two Hydrogel Scaffolds on Spinal Cord Injury

et al. 2022

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Background: Spinal cord injury (SCI) is a severe neurological disease leading to poor quality of life. Objectives: The regenerative effect of adipose-derived mesenchymal stem cells (AD-MSCs) encapsulated into fibrin, and collagen hydrogel scaffolds on a rat model of SCI was investigated using clinical and histopathological examinations. Methods: A total of 18 adult male Wistar rats (250 - 300 g) were prepared and randomly divided into three equal groups, each with six rats, including the control or SCI group (SCI contusion model without treatment), SCI contusion model treated with AD-MSCs encapsulated in fibrin hydrogel, and SCI contusion model treated with AD-MSCs encapsulated in collagen hydrogel groups. Clinically, functional recovery or hindlimb locomotor activity was assessed using Basso, Beattie, and Bresnahan's (BBB) scoring system four weeks post-treatment. The rats were sacrificed at week four post-treatment, and their spinal cords were examined histopathologically. Results: Faster functional recovery indicated with hindlimb locomotor activity was seen in both treatment groups compared to the control group. Severe polio and leuko-myelomalacia associated with disruption of spinal cord structure were identified in the control group. Mild polio and leuko-myelomalacia associated with mild to moderate disruption of spinal cord structure were seen in the collagen hydrogel + AD-MSCs and fibrin hydrogel + AD-MSCs groups. Conclusions: AD-MSCs encapsulated into fibrin and collagen hydrogels, as two of the most promising ECM-based or natural scaffolds have the potential to be developed in neural tissue engineering (NTE), such as for the treatment of SCI.

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Injectable hydrogels in stroke and spinal cord injury treatment: a review on hydrogel materials, cell–matrix interactions and glial involvement

Abstract: Central nervous system (CNS) pathologies, such as stroke and spinal cord injury, remain debilitating issues due to the inhibitory environment in the CNS. Many research works have focused on combinatorial...

Cited by 28 publications

References 172 publications

Biomaterial-Mediated Factor Delivery for Spinal Cord Injury Treatment

Biomaterial-Mediated Factor Delivery for Spinal Cord Injury Treatment

Perspective Insights to Bio-Nanomaterials for the Treatment of Neurological Disorders

Comparison of the Regenerative Effect of Adipose Tissue Mesenchymal Stem Cell Encapsulated into Two Hydrogel Scaffolds on Spinal Cord Injury

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