Injectable hydrogels for targeted delivering of therapeutic molecules for tissue engineering and disease treatment

Mavlyanova, Rukhshona; Yang, Rufeng; Tao, Tao; Aquib, Md; Kesse, Samuel; Maviah, Mily Bazezy Joelle; Boakye‐Yiadom, Kofi Oti; Farooq, Muhammad Asim; Wang, Bo

doi:10.1002/pat.4763

Cited by 10 publications

(5 citation statements)

References 76 publications

(83 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Slow gel formation results in poor adaptation and network formation, altering the cell encapsulation as the therapeutics may flow away from the targeted site. Furthermore, fast gel formation makes it difficult to inject in the targeted site [ 74 , 75 ].…”

Section: Discussionmentioning

confidence: 99%

Hydrogel-Based Biomaterial as a Scaffold for Gingival Regeneration: A Systematic Review of In Vitro Studies

et al. 2023

View full text Add to dashboard Cite

Background: Hydrogel is considered a promising scaffold biomaterial for gingival regeneration. In vitro experiments were carried out to test new potential biomaterials for future clinical practice. The systematic review of such in vitro studies could synthesize evidence of the characteristics of the developing biomaterials. This systematic review aimed to identify and synthesize in vitro studies that assessed the hydrogel scaffold for gingival regeneration. Methods: Data on experimental studies on the physical and biological properties of hydrogel were synthesized. A systematic review of the PubMed, Embase, ScienceDirect, and Scopus databases was conducted according to the Preferred Reporting System for Systematic Reviews and Meta-Analyses (PRISMA) 2020 statement guidelines. In total, 12 original articles on the physical and biological properties of hydrogels for gingival regeneration, published in the last 10 years, were identified. Results: One study only performed physical property analyses, two studies only performed biological property analyses, and nine studies performed both physical and biological property analyses. The incorporation of various natural polymers such as collagen, chitosan, and hyaluronic acids improved the biomaterial characteristics. The use of synthetic polymers faced some drawbacks in their physical and biological properties. Peptides, such as growth factors and arginine–glycine–aspartic acid (RGD), can be used to enhance cell adhesion and migration. Based on the available primary studies, all studies successfully present the potential of hydrogel characteristics in vitro and highlight the essential biomaterial properties for future periodontal regenerative treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Hydrogel-Based Biomaterial as a Scaffold for Gingival Regeneration: A Systematic Review of In Vitro Studies

et al. 2023

View full text Add to dashboard Cite

show abstract

“…For additional details on the synthesis and gelation mechanisms of injectable hydrogels, we suggest several recent review articles. [13,14,17,24,25]…”

Section: Injectable Hydrogelsmentioning

confidence: 99%

Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

Rizzo

Kehr

2020

Adv Healthcare Materials

199

152

View full text Add to dashboard Cite

Injectable hydrogels have received considerable interest in the biomedical field due to their potential applications in minimally invasive local drug delivery, more precise implantation, and site‐specific drug delivery into poorly reachable tissue sites and into interface tissues, where wound healing takes a long time. Injectable hydrogels, such as in situ forming and/or shear‐thinning hydrogels, can be generated using chemically and/or physically crosslinked hydrogels. Yet, for controlled and local drug delivery applications, the ideal injectable hydrogel should be able to provide controlled and sustained release of drug molecules to the target site when needed and should limit nonspecific drug molecule distribution in healthy tissues. Thus, such hydrogels should sense the environmental changes that arise in disease states and be able to release the optimal amount of drug over the necessary time period to the target region. To address this, researchers have designed stimuli‐responsive injectable hydrogels. Stimuli‐responsive hydrogels change their shape or volume when they sense environmental stimuli, e.g., pH, temperature, light, electrical signals, or enzymatic changes, and deliver an optimal concentration of drugs to the target site without affecting healthy tissues.

show abstract

“…The major compelling advantages of injectable hydrogels are the involvement of a minimally invasive technique and the ability to bypass first-pass metabolism. 229 The injectable and self-healing anesthetic Oleogel, derived from glycolipid, was developed, which showed better antibiofilm and wound closure performance in a diabetic rat wound model. 230 Additionally, a composite gel was also prepared by encapsulating curcumin in Oleogel.…”

Section: Biomaterial-based Approaches For Woundmentioning

confidence: 99%

Biomaterials-Based Regenerative Strategies for Skin Tissue Wound Healing

Kaur

Narayanan

Garg

et al. 2022

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

Skin tissue wound healing proceeds through four major stages, including hematoma formation, inflammation, and neo-tissue formation, and culminates with tissue remodeling. These four steps significantly overlap with each other and are aided by various factors such as cells, cytokines (both anti- and pro-inflammatory), and growth factors that aid in the neo-tissue formation. In all these stages, advanced biomaterials provide several functional advantages, such as removing wound exudates, providing cover, transporting oxygen to the wound site, and preventing infection from microbes. In addition, advanced biomaterials serve as vehicles to carry proteins/drug molecules/growth factors and/or antimicrobial agents to the target wound site. In this review, we report recent advancements in biomaterials-based regenerative strategies that augment the skin tissue wound healing process. In conjunction with other medical sciences, designing nanoengineered biomaterials is gaining significant attention for providing numerous functionalities to trigger wound repair. In this regard, we highlight the advent of nanomaterial-based constructs for wound healing, especially those that are being evaluated in clinical settings. Herein, we also emphasize the competence and versatility of the three-dimensional (3D) bioprinting technique for advanced wound management. Finally, we discuss the challenges and clinical perspective of various biomaterial-based wound dressings, along with prospective future directions. With regenerative strategies that utilize a cocktail of cell sources, antimicrobial agents, drugs, and/or growth factors, it is expected that significant patient-specific strategies will be developed in the near future, resulting in complete wound healing with no scar tissue formation.

show abstract

Injectable hydrogels for targeted delivering of therapeutic molecules for tissue engineering and disease treatment

Cited by 10 publications

References 76 publications

Hydrogel-Based Biomaterial as a Scaffold for Gingival Regeneration: A Systematic Review of In Vitro Studies

Hydrogel-Based Biomaterial as a Scaffold for Gingival Regeneration: A Systematic Review of In Vitro Studies

Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

Biomaterials-Based Regenerative Strategies for Skin Tissue Wound Healing

Contact Info

Product

Resources

About