Injectable hydrogels as novel materials for central nervous system regeneration

Niemczyk, B; Sajkiewicz, Paweł; Kołbuk, Dorota

doi:10.1088/1741-2552/aacbab

Cited by 60 publications

(60 citation statements)

References 137 publications

(246 reference statements)

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“…Hydrogels possess tunable physical and chemical properties [ [7] , [8] , [9] ], which in the context of brain regeneration, are expected to meet the following requirements: Injectability, shear-thinning and self-healing (thixotropy). The ability of hydrogel to support both viscous flow under shear stress (shear-thinning during injection) and time-dependent recovery upon relaxation (self-healing after injection at the injury site) are the major requirements for minimally invasive surgery [ 10 , 11 ]. Biocompatibility, low cytotoxicity and immunogenicity and the lack of mutagenicity.…”

Section: Introductionmentioning

confidence: 99%

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Hydrogel-assisted neuroregeneration approaches towards brain injury therapy: A state-of-the-art review

Kornev

Grebenik

Solovieva

et al. 2018

Computational and Structural Biotechnology Journal

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Recent years have witnessed the development of an enormous variety of hydrogel-based systems for neuroregeneration. Formed from hydrophilic polymers and comprised of up to 90% of water, these three-dimensional networks are promising tools for brain tissue regeneration. They can assist structural and functional restoration of damaged tissues by providing mechanical support and navigating cell fate. Hydrogels also show the potential for brain injury therapy due to their broadly tunable physical, chemical, and biological properties. Hydrogel polymers, which have been extensively implemented in recent brain injury repair studies, include hyaluronic acid, collagen type I, alginate, chitosan, methylcellulose, Matrigel, fibrin, gellan gum, self-assembling peptides and proteins, poly(ethylene glycol), methacrylates, and methacrylamides. When viewed as tools for neuroregeneration, hydrogels can be divided into: (1) hydrogels suitable for brain injury therapy, (2) hydrogels that do not meet basic therapeutic requirements and (3) promising hydrogels which meet the criteria for further investigations. Our analysis shows that fibrin, collagen I and self-assembling peptide-based hydrogels display very attractive properties for neuroregeneration.

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Section: Introductionmentioning

confidence: 99%

“…Injectability, shear-thinning and self-healing (thixotropy). The ability of hydrogel to support both viscous flow under shear stress (shear-thinning during injection) and time-dependent recovery upon relaxation (self-healing after injection at the injury site) are the major requirements for minimally invasive surgery [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Hydrogel-assisted neuroregeneration approaches towards brain injury therapy: A state-of-the-art review

Kornev

Grebenik

Solovieva

et al. 2018

Computational and Structural Biotechnology Journal

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“…From another perspective, due to the large surface area, NMs can effectively increase biological functionality, hence NC hydrogels have been shown to more closely mimic native tissues compared with free-NM hydrogels (Kehr et al, 2015). In the case of some specific applications, e.g., regeneration of the central nervous system, the addition of nanofibers to a hydrogel matrix can be morphologically beneficial because the elongated shape of the scaffold is favored by neural cells (Niemczyk et al, 2018).…”

Section: Tailored Hydrogels For Tissue Engineeringmentioning

confidence: 99%

Insight Into the Current Directions in Functionalized Nanocomposite Hydrogels

et al. 2020

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Since the introduction of tissue engineering as an encouraging method for the repair and regeneration of injured tissue, there have been many attempts by researchers to construct bio-mimetic scaffolds which mimic the native extracellular matrix, with the aim of promoting cell growth, cell proliferation, and restoration of the tissue's native functionality. Among the different materials and methods of scaffold fabrication, one particularly promising class of materials, hydrogels, has been extensively studied, with the inclusion of nano-scaled materials into hydrogels leading to the creation of an exciting new generation of nanocomposites, known as nanocomposite hydrogels. To closely mimic the native tissue behavior, scientists have recently focused on the functionalization of incorporated nanomaterials via chiral biomolecules, with reported results showing great potential. The current article aims to introduce a perspective of nano-scaled cellulose as a promising nanomaterial which can be multi-functionalized for the fabrication of nanocomposite hydrogels with applications in tissue engineering and drug delivery systems. This article also briefly reviews the recently reported literature on nanocomposite hydrogels incorporated with chiral functionalized nanomaterials. Such knowledge paves the path for the development of tailored hydrogels toward practical applications.

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“…The nervous system is the most complicated system in the body affecting the sensory and motor functions, when the system is damaged. Injuries of the central nervous system (CNS), i.e., brain and spinal cord, lead usually to permanent disability due to severe limitations for spontaneous regeneration of the CNS [1][2][3][4][5][6][7][8][9], leading to considerable socio-economic problems. For instance, 577 cases of traumatic brain injuries (TBI) per 100,000 people per year occurred in the U.S. alone, while, in Europe, the number of patients with diagnosed TBI was estimated at 262 per 100,000 [10].…”

Section: Introductionmentioning

confidence: 99%

Piezoelectric Scaffolds as Smart Materials for Neural Tissue Engineering

2020

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Injury to the central or peripheral nervous systems leads to the loss of cognitive and/or sensorimotor capabilities, which still lacks an effective treatment. Tissue engineering in the post-injury brain represents a promising option for cellular replacement and rescue, providing a cell scaffold for either transplanted or resident cells. Tissue engineering relies on scaffolds for supporting cell differentiation and growth with recent emphasis on stimuli responsive scaffolds, sometimes called smart scaffolds. One of the representatives of this material group is piezoelectric scaffolds, being able to generate electrical charges under mechanical stimulation, which creates a real prospect for using such scaffolds in non-invasive therapy of neural tissue. This paper summarizes the recent knowledge on piezoelectric materials used for tissue engineering, especially neural tissue engineering. The most used materials for tissue engineering strategies are reported together with the main achievements, challenges, and future needs for research and actual therapies. This review provides thus a compilation of the most relevant results and strategies and serves as a starting point for novel research pathways in the most relevant and challenging open questions.

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Injectable hydrogels as novel materials for central nervous system regeneration

Abstract: We highlight injectable hydrogels with various micro-and nanoparticles, because of novelty and attractiveness of this type of materials for CNS regeneration and future development perspectives.

Cited by 60 publications

References 137 publications

Hydrogel-assisted neuroregeneration approaches towards brain injury therapy: A state-of-the-art review

Hydrogel-assisted neuroregeneration approaches towards brain injury therapy: A state-of-the-art review

Insight Into the Current Directions in Functionalized Nanocomposite Hydrogels

Piezoelectric Scaffolds as Smart Materials for Neural Tissue Engineering

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