Injectable hydrogel therapies and their delivery strategies for treating myocardial infarction

Johnson, Todd D.; Christman, Karen L.

doi:10.1517/17425247.2013.739156

Cited by 203 publications

(160 citation statements)

References 80 publications

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“…The main disadvantage of this polymer refers to their week mechanical properties, but these properties can be improved by modifying the molecular structure and composition with various functionalization [3,7,[35][36][37].…”

Section: Hyaluronic Acid (Ha)mentioning

confidence: 99%

Hydrogels for Cardiac Tissue Repair and Regeneration

Grigore¹

2017

J Cardiovasc Med Cardiol

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The main cause of death in the world continues to be cardiovascular disease, which affects annually over 900,000 people and in the entire word approximately 50% of the people suffering myocardial infarction (MI) die within 5 years. MI causes a number of cardiac pathologies like hypertension, blocked coronary arteries and valvular heart diseases resulting ischemic cardiac injury. In the last years, cardiac tissue engineering has made considerable progress, because this progress have been made towards developing injectable hydrogels for the purpose of cardiac repair and/or regeneration. This study aims to provide an updated survey of the major progress in the fl ied of injectable cardiac tissue engineering, including biomaterials (natural, synthetic or hybrid hydrogels), their advantages or disadvantages and the main seeding cell sources. Also, this review focuses on the progress made in the fi eld of hydrogels for cardiac tissue repair and/or regeneration for MI over the last years.

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Section: Hyaluronic Acid (Ha)mentioning

confidence: 99%

Hydrogels for Cardiac Tissue Repair and Regeneration

Grigore¹

2017

J Cardiovasc Med Cardiol

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“…These hydrogels can limit wall stress that leads to pathological dilative remodeling of the ventricle as well as provide a protective environment to improve retention and function of transplanted cells (Johnson and Christman, 2013). Another ECM therapy approach is the fabrication of nanofiber matrices (Zhang, 2003).…”

Section: Nanofibrous Materials For Cardiac Tissue Repairingmentioning

confidence: 99%

Nano-Engineered Biomaterials for Tissue Regeneration: What Has Been Achieved So Far?

et al. 2016

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Nanomaterials have attracted the interest of tissue engineers for the last two decades. Their unique properties make them promising for de novo fabrication of bio-inspired hybrid/composite materials with improved regenerative properties, including, for example, the capacity for electric conductivity and the provision of antimicrobial properties. However, to this day, the use of such materials in medical applications is rather limited and most of the studies have only reached the archetypical proof-of-concept stage. Herein, we present a review on the use of nanomaterials in tissue engineering for regenerative therapies of heart, skin, eye, skeletal muscle, and nervous system. The advantages and limitations of nano-engineering materials are presented in this review alongside with the future challenges and milestones nanotechnology must overcome to make an impact in biomedical applications.

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“…Limited positive results have been reported with hydrogels prepared using only poly(ethylene-glycol) (PEG) [54]. However, several PEG copolymer hydrogels have shown benefits.…”

Section: Hydrogels In Cell-based Therapiesmentioning

confidence: 99%

Heart regeneration after myocardial infarction using synthetic biomaterials

Pascual-Gil

Garbayo

Díaz-Herráez

et al. 2015

Journal of Controlled Release

121

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Abstract:Myocardial infarction causes almost 7.3 million deaths each year worldwide. However, current treatments are more palliative than curative. Presently, cell and protein therapies are considered the most promising alternative treatments. Clinical trials performed until now have demonstrated that these therapies are limited by protein short half-life and by low transplanted cell survival rate, prompting the development of novel cell and protein delivery systems able to overcome such limitations. In this review we discuss the advances made in the last 10 years in the emerging field of cardiac repair using biomaterial-based delivery systems with focus on the progress made on preclinical in vivo studies. Then, we focus in cardiac tissue engineering approaches, and how the incorporation of both cells and proteins together into biomaterials has opened new horizons in the myocardial infarction treatment. Finally, the ongoing challenges and the perspectives for future work in cardiac tissue engineering will also be discussed.

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Injectable hydrogel therapies and their delivery strategies for treating myocardial infarction

Cited by 203 publications

References 80 publications

Hydrogels for Cardiac Tissue Repair and Regeneration

Hydrogels for Cardiac Tissue Repair and Regeneration

Nano-Engineered Biomaterials for Tissue Regeneration: What Has Been Achieved So Far?

Heart regeneration after myocardial infarction using synthetic biomaterials

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