Injectable, Highly Flexible, and Thermosensitive Hydrogels Capable of Delivering Superoxide Dismutase

Li, Zhenqing; Wang, Zewei; Roy, Sashwati; Sen, Chandan K.; Guan, Jianjun

doi:10.1021/bm900900e

Cited by 89 publications

(91 citation statements)

References 54 publications

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“…Fujimoto et al synthesized similar hydrogels and injected into infarcted hearts and an improvement of heart function was observed [45]. Guan et al further functionalized the developed PNIPAAm hydrogels with growth factor [46] and antioxidants [47]. It was found that functionalization significantly enhanced MSC growth within the hydrogels.…”

Section: Polyacrylamide and Its Derivativesmentioning

confidence: 99%

“…An elastic hydrogel is likely needed to withstand the mechanical cycling. The highly extensible PNIPAAm-based hydrogels developed in our laboratory may be good candidates for this approach [44,46,47].…”

Section: Aligned Vs Isotropicmentioning

confidence: 99%

“…Therefore, they need to be protected and gradually released from the hydrogels. Chemical conjugation [46] and physical entrapping [47] have been shown to be good approaches.…”

Section: Functionalization Of Hydrogelsmentioning

confidence: 99%

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Hydrogels for Cardiac Tissue Engineering

2011

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Cardiac tissue regeneration is an integrated process involving both cells and supporting matrix. Cardiomyocytes and stem cells are utilized to regenerate cardiac tissue. Hydrogels, because of their tissue-like properties, have been used as supporting matrices to deliver cells into infarcted cardiac muscle. Bioactive and biocompatible hydrogels mimicking biochemical and biomechanical microenvironments in native tissue are needed for successful cardiac tissue regeneration. These hydrogels not only retain cells in the infarcted area, but also provide support for restoring myocardial wall stress and cell survival and functioning. Many hydrogels, including natural polymer hydrogels, synthetic polymer hydrogels, and natural/synthetic hybrid hydrogels are employed for cardiac tissue engineering. In this review, types of hydrogels used for cardiac tissue engineering are briefly introduced. Their advantages and disadvantages are discussed. Furthermore, strategies for cardiac regeneration using hydrogels are reviewed.

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Section: Polyacrylamide and Its Derivativesmentioning

confidence: 99%

Section: Aligned Vs Isotropicmentioning

confidence: 99%

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Hydrogels for Cardiac Tissue Engineering

2011

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“…In particular, heat-induced gelation materials, which undergo a thermally reversible transition from a low viscosity solution to a rigid gel upon an increase in temperature, have attracted considerable attention as injectable drugdelivery systems 3 . The most notable heat-induced gelator is the cross-linked poly N-isopropylacrylamide PNIPAM hydrogel, which exhibits a volume phase transition upon heating through its lower critical-solution temperature LCST 4 .…”

Section: Introductionmentioning

confidence: 99%

Double-stimuli Responsive O/W Emulsion Gel Based on a Novel Amidoamine Surfactant

et al. 2011

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“…The polymer solutions were able to form gel in-situ and then degrade. 80,161,186 In these systems, the hydrogels were formed at body temperature, 37 o C, yet became soluble at this temperature after degradation, allowing the by-product to be dissolved and excreted from body.…”

Section: Thermoresponsive Hydrogels In Drug and Gene Delivery And Chamentioning

confidence: 99%

Synthesis of timed-release polymer nanoparticles

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Polymeric carriers for drug and gene delivery have been successfully used in clinical applications, and developing to achieve greater efficacy. A successful polymeric carrier must not only protect the therapeutics from degradation but also increase the pharmacokinetic and biopharmaceutical properties of the therapeutic agents. Furthermore, releasing the therapeutic agents from nanocarriers at the desired target sites and with the correct dosage is important to enhance patient outcomes.Numerous polymeric systems for drug and gene delivery that can release bioactive agents through response to external (e.g., light, electric or magnetic source, and ultrasound) or internal triggers (e.g., pH, enzyme, and redox) have been designed. However, release mechanism using these triggers is restrictive in terms of in vivo applications as there is limited accessibility of external stimuli to tissues or organs; and the efficiency of internal triggers are variable between cell lines and even within the same tissue or organ. Some carriers are not degradable, raising the important issue of toxicity due to accumulation in the body and healthy cells. In addition, the time of release is mostly uncontrollable. The main aim of this thesis is to synthesize and study of novel non-triggered and timed-release polymeric carriers, such as micelles and hydrogel, based on thermoresponsive PNIPAM and self-degradable PDMAEA. In particular, we developed the understanding of the selfassembly and disassembly properties of thermoresponsive PNIPAM copolymerized with the selfdegradable PDMAEA and hydrophobic components. This is one of the first examples where the disassembly time can be controlled on-demand in a wide range of experimental conditions. Initially, the self-catalysed hydrolysis of PDMAEA together with hydrophobic polymers were employed to finely tune the LCST and disassembly time of thermoresponsive PNIPAM and thus control the release time of oligo DNA (i.e., mimic of siRNA) from the polymer complex. The diblock thermoresponsive copolymers were synthesized by Reversible addition-fragmentation chain transfer (RAFT) polymerization, which consisted of a hydrophilic block (e.g., PDMA) for stabilization and a second thermoresponsive block with three components (e.g., NIPAM, DMAEA, and BA or Styrene) for self-assembly and disassembly. The copolymers were fully water-soluble below LCST and self-assembled into core-shell spherical particles with an average diameter of approximately 25 nm above LCST (e.g., 37 o C) and with a narrow particle size distribution. When the amount of acid groups from degradation of cationic DMAEA units was sufficiently high to increase LCST of the copolymer above 37 °C, the polymer nanoparticles sharply disassembled to unimers (i.e., the core of the copolymer became water soluble). These nanoparticles showed excellent binding to oligo DNA without any leakage until full disassembly to unimers. Interestingly, the disassembly time of the nanoparticles and consequently the release time of oligo DNA could be precisel...

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Injectable, Highly Flexible, and Thermosensitive Hydrogels Capable of Delivering Superoxide Dismutase

Cited by 89 publications

References 54 publications

Hydrogels for Cardiac Tissue Engineering

Hydrogels for Cardiac Tissue Engineering

Double-stimuli Responsive O/W Emulsion Gel Based on a Novel Amidoamine Surfactant

Synthesis of timed-release polymer nanoparticles

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