Injectable ferrimagnetic silk fibroin hydrogel for magnetic hyperthermia ablation of deep tumor

Qian, Kun‐Yu; Song, Yonghong; Xu, Yan; Dong, Liang; Xue, Jingzhe; Xu, Yongfen; Wang, Bao; Cao, Baoqiang; Hou, Qingbing; Peng, Wei; Hu, Jinlong; Jiang, Kun; Chen, Sheng; Wang, Huiqing; Lu, Yang

doi:10.1016/j.biomaterials.2020.120299

Cited by 87 publications

(62 citation statements)

References 53 publications

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“…Salloum et al fabricated a ferrofluid-based injectable agarose gel for hyperthermia applications [ 133 ]. Qian et al prepared a PEG-stabilized iron-oxide-nanocube-loaded silk fibroin hydrogel for antitumor therapy [ 134 ]. This hydrogel ( Figure 9 ) showed shear thinning behavior and was applied as an injectable hydrogel.…”

Section: Hyperthermia-based Cancer Treatmentmentioning

confidence: 99%

Design of Magnetic Hydrogels for Hyperthermia and Drug Delivery

Ganguly

Margel

2021

Polymers

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Hydrogels are spatially organized hydrophilic polymeric systems that exhibit unique features in hydrated conditions. Among the hydrogel family, composite hydrogels are a special class that are defined as filler-containing systems with some tailor-made properties. The composite hydrogel family includes magnetic-nanoparticle-integrated hydrogels. Magnetic hydrogels (MHGs) show magneto-responsiveness, which is observed when they are placed in a magnetic field (static or oscillating). Because of their tunable porosity and internal morphology they can be used in several biomedical applications, especially diffusion-related smart devices. External stimuli may influence physical and chemical changes in these hydrogels, particularly in terms of volume and shape morphing. One of the most significant external stimuli for hydrogels is a magnetic field. This review embraces a brief overview of the fabrication of MHGs and two of their usages in the biomedical area: drug delivery and hyperthermia-based anti-cancer activity. As for the saturation magnetization imposed on composite MHGs, they are easily heated in the presence of an alternating magnetic field and the temperature increment is dependent on the magnetic nanoparticle concentration and exposure time. Herein, we also discuss the mode of different therapies based on non-contact hyperthermia heating.

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Section: Hyperthermia-based Cancer Treatmentmentioning

confidence: 99%

Design of Magnetic Hydrogels for Hyperthermia and Drug Delivery

Ganguly

Margel

2021

Polymers

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“…Most organic molecule-based materials have strong NIR absorption capability, solubility, biocompatibility, and dispersibility, but they also need modification to promote bone regeneration or immunomodulation [ 204 , 205 ]. Studies of these four types of PTAs are constantly progressing, and the main purpose is to improve the photothermal conversion efficiency, solubility, biocompatibility, tumor-targeting capacity, and safety via modification and nanoformulation [ 206 , 207 , 208 ]. Moreover, recently, PTT is usually combined with other therapies to comprehensively improve the therapeutic effects of bone cancer [ 209 , 210 , 211 ].…”

Section: Pttmentioning

confidence: 99%

Progress of Phototherapy Applications in the Treatment of Bone Cancer

Sun

Xing

Braun

et al. 2021

IJMS

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Bone cancer including primary bone cancer and metastatic bone cancer, remains a challenge claiming millions of lives and affecting the life quality of survivors. Conventional treatments of bone cancer include wide surgical resection, radiotherapy, and chemotherapy. However, some bone cancer cells may remain or recur in the local area after resection, some are highly resistant to chemotherapy, and some are insensitive to radiotherapy. Phototherapy (PT) including photodynamic therapy (PDT) and photothermal therapy (PTT), is a clinically approved, minimally invasive, and highly selective treatment, and has been widely reported for cancer therapy. Under the irradiation of light of a specific wavelength, the photosensitizer (PS) in PDT can cause the increase of intracellular ROS and the photothermal agent (PTA) in PTT can induce photothermal conversion, leading to the tumoricidal effects. In this review, the progress of PT applications in the treatment of bone cancer has been outlined and summarized, and some envisioned challenges and future perspectives have been mentioned. This review provides the current state of the art regarding PDT and PTT in bone cancer and inspiration for future studies on PT.

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“…In order to pursue more biocompatibility, injectable ferromagnetic silk fibroin hydrogel was used for magnetic hyperthermia ablation. The hydrogel was made by natural biopolymer silk fibroin, and it did not reduce the viability of cells and function of the main organs in mice [190]. These methods can reduce the side effects on the non-therapeutic area in terms of selective heating and accumulation.…”

Section: Magnetothermal Effectmentioning

confidence: 99%

Adaptive iron-based magnetic nanomaterials of high performance for biomedical applications

Zhang

2021

Nano Res.

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With unique physicochemical properties and biological effects, magnetic nanomaterials (MNMs) play a crucial role in the biomedical field. In particular, magnetic iron oxide nanoparticles (MIONPs) are approved by the United States Food and Drug Administration (FDA) for clinical applications at present due to their low toxicity, biocompatibility, and biodegradability. Despite the unarguable effectiveness, massive space for improving such materials' performance still needs to be filled. Recently, many efforts have been devoted to improving the preparation methods based on the materials' biosafety. Besides, researchers have successfully regulated the performance of magnetic nanoparticles (MNPs) by changing their sizes, morphologies, compositions; or by aggregating as-synthesized MNPs in an orderly arrangement to meet various clinical requirements. The rise of cloud computing and artificial intelligence techniques provides novel ways for fast material characterization, automated data analysis, and mechanism demonstration. In this review, we summarized the studies that focused on the preparation routes and performance regulations of high-quality MNPs, and their special properties applied in biomedical detection, diagnosis, and treatment. At the same time, the future development of MNMs was also discussed.

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Injectable ferrimagnetic silk fibroin hydrogel for magnetic hyperthermia ablation of deep tumor

Cited by 87 publications

References 53 publications

Design of Magnetic Hydrogels for Hyperthermia and Drug Delivery

Design of Magnetic Hydrogels for Hyperthermia and Drug Delivery

Progress of Phototherapy Applications in the Treatment of Bone Cancer

Adaptive iron-based magnetic nanomaterials of high performance for biomedical applications

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