Injectable eprinomectin for cattle: Tick efficacy and pharmacokinetics

Abstract

The aims of the present study were to evaluate the pharmacokinetic profile and efficacy of eprinomectin (EPM) against Rhipicephalus microplus in cattle of a new injectable form of EPM (Voss Performa®). The product was administered subcutaneously at a dose of 200 μg EPM/kg, in a single dose. The efficacy of EPM against R. microplus in cattle was evaluated through field and stall tests. Studies were performed to estimate the pharmacokinetic parameters of EPM with the purpose of better understanding the kinetics of the formulation. The formulation was effective in controlling R. microplus in both naturally and artificially infested cattle, providing efficacy greater than 95%. The results of pharmacokinetic study were Cmax of 47.15 ± 22.20 ng/ml, Tmax of 1.33 ± 0.492 days, T1/2 of 2.96 ± 1.212 days, AUC0–t of 228.08 ± 57.30 ng day ml−1, and AUC0‐∞ of 240.50 ± 58.44 ng day ml−1. Therefore, the new injectable EPM formulation becomes an important alternative for the control of cattle tick in Brazil.

Pharmacokinetics and milk excretion pattern of eprinomectin at different dose rates in dairy cattle

“…Besides the traditional topical preparation, injectable formulations of EPM were launched to the pharmaceutical market in different countries such as South Africa, Turkey and Brazil (Aksit et al, 2016; do Nascimento et al, 2020) to be administered subcutaneously at 0.2 mg/kg. The injectable EPM provides a greater systemic availability and peak concentration than the topical administration at 0.5 mg/kg but some of them have lost the advantage of the withdrawal period 0 in milk after their administration in lactating dairy cows.…”