Injectable collagen implant—update

Castrow, Fred F.; Krull, Edward A.

doi:10.1016/s0190-9622(83)70204-5

Cited by 83 publications

(44 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…2,10,11,17,19,25,26,57,71,118,122,[125][126][127][128] If it is treated early and with sufficient high doses of corticosteroids, it does not recur.…”

Section: Possible Causes Of Granuloma Formationmentioning

confidence: 99%

See 1 more Smart Citation

Foreign Body Granulomas after All Injectable Dermal Fillers: Part 1. Possible Causes

Lemperle

Gauthier-Hazan

Wolters

et al. 2009

Plastic and Reconstructive Surgery

220

243

View full text Add to dashboard Cite

Summary Genuine granuloma formation following implantation of injectable dermal fillers is a rare complication, with incidences ranging from one in 100 patients (1 percent) to one in 5000 (0.02 percent). Foreign body granulomas occur several months to years after injection at all implantation sites at the same time. Without treatment, they may grow to the size of beans, remain virtually unchanged for some years, and then resolve spontaneously. Three clinical and histologic types of foreign body granulomas can be distinguished: 1. Cystic granulomas (synonyms: inflammatory, palisading, collagenolytic): these are caused mainly by injected biological gels such as collagens and hyaluronic acids. Their clinical signs are fluctuation (sterile abscess), extreme redness, and induration. Cystic granulomas are small and superficial, occur within the first year, and disappear spontaneously within another year. They are surrounded by a significant number of giant cells. 2. Edematous granulomas (synonym: lipogranuloma): these are caused by artificial fluids such as silicone and polyacrylamides. They appear suddenly years after injection with extensive swelling and are surrounded and infiltrated by mononuclear and inflammatory cells. 3. Sclerosing granulomas (synonyms: sarcoidal and xanthelasmic): these are caused by particulate injectables composed of polymethylmethacrylate, polylactic acid, hydroxyethylmethacrylate, calcium-hydroxylapatite, or dextran microspheres. Sclerosing granulomas occur generally 6 months to 3 years after implantation and are visible, often bluish confined nodules. Histologically, the implant is infiltrated by many macrophages and giant cells, fibroblasts, and collagen fibers but few inflammatory cells. Permanent implants are not characterized by a higher rate of foreign body granuloma per se than temporary implants; however, their clinical appearance is more pronounced and their persistence longer if not treated adequately. (Plast.

show abstract

“…2,10,11,17,19,25,26,57,71,118,122,[125][126][127][128] If it is treated early and with sufficient high doses of corticosteroids, it does not recur.…”

Section: Possible Causes Of Granuloma Formationmentioning

confidence: 99%

“…10,11,[15][16][17][18][19][20][21][22][23][24][25][26][27][28] In general, foreign body granulomas are of nonallergenic origin: we have tested two former granuloma patients, years after successful injections, with the same material and they did not form granulomas at the test sites. Therefore, a typical foreign body granuloma (Fig.…”

mentioning

confidence: 99%

Foreign Body Granulomas after All Injectable Dermal Fillers: Part 1. Possible Causes

Lemperle

Gauthier-Hazan

Wolters

et al. 2009

Plastic and Reconstructive Surgery

220

243

View full text Add to dashboard Cite

show abstract

“…In einer Studie mit etwa 7000 Patienten, die mit bovinem Kollagen behandelt waren, wurde eine Nebenwirkungsrate von 1,5% in Form von vorüberge-hender Schwellung, Erythem, Verhär-tungen, Juckreiz und Hämatom beobachtet [7].…”

Section: Nebenwirkungen In Unmittelbarem Zusammenhang Mit Der Behandlungunclassified

Spektrum der Komplikationennach Behandlung mit injizierbaren Füllmaterialien

2009

MKG-Chirurg

View full text Add to dashboard Cite

“…In einer Studie mit etwa 7000 Patienten, die mit bovinem Kollagen behandelt waren, wurde eine Nebenwirkungsrate von 1,5% in Form von vorübergehender Schwellung, Erythem, Verhärtungen, Juckreiz und Hämatom beobachtet [7].…”

Section: Nebenwirkungen In Unmittelbarem Zusammenhang Mit Der Behandlungunclassified

Spektrum der Komplikationen nach Behandlung mit injizierbaren Füllmaterialien

Wiest¹

2009

J. f. Ästhet. Chirurgie

View full text Add to dashboard Cite

Injectable collagen implant—update

Cited by 83 publications

References 4 publications

Foreign Body Granulomas after All Injectable Dermal Fillers: Part 1. Possible Causes

Foreign Body Granulomas after All Injectable Dermal Fillers: Part 1. Possible Causes

Spektrum der Komplikationennach Behandlung mit injizierbaren Füllmaterialien

Spektrum der Komplikationen nach Behandlung mit injizierbaren Füllmaterialien

Contact Info

Product

Resources

About