Injectable Caltrop Fruit Saponin Protects Against Ischemia-Reperfusion Injury in Rat Brain

Yan, Linggeng; Lu, Yin; Zheng, Shizhong; Wang, Aiyun; Li, Meng-Qiu; Ruan, Junshan; Zhang, Lei

doi:10.1142/s0192415x11008853

Cited by 6 publications

(1 citation statement)

References 22 publications

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“…27,28 However, MDA, as one of the final products in the peroxidation, could reflect the changes in the free radicals and the degree of damage to the tissue through its variation. 29 More importantly, recent evidence has shown a close correlation between oxidative stress and cell apoptosis. 30 During the cerebral ischemia, ROS could induce the neuronal apoptosis via many pathways.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: Neuroprotection of chromobox 7 knockout in the mouse after cerebral ischemia-reperfusion injury via nuclear factor E2-related factor 2/hemeoxygenase-1 signaling pathway

et al. 2021

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Objective To explore the mechanism of chromobox 7 (CBX7)-mediated nuclear factor E2-related factor 2 (Nrf2)/hemeoxygenase-1 (HO-1) signaling pathway in the cerebral ischemia/reperfusion (I/R) injury. Methods The experimental wild-type (WT) and CBX7-/- mice were used to establish cerebral I/R models using the middle cerebral artery occlusion (MCAO) surgery to determine CBX7 levels at different time points after MCAO injury. For all mice, neurological behavior, infarct size, water content, and oxidative stress–related indicators were determined, and transferase (TdT)-mediated dUTP-biotin nick-end labeling (terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling (TUNEL)) staining method was employed to observe cell apoptosis, while Western blot to measure the expression of CBX7 and Nrf/HO-1 pathway-related proteins. Results At 6 h, 12 h, 24 h, 3 days, and 7 days after mice with MCAO, CBX7 expression was gradually up-regulated and the peak level was reached at 24 h. Mice in the WT + MCAO group had increased infarct size, with significant increases in the modified neurological severity scores and water content in the brain, as well as the quantity of TUNEL-positive cells. For the oxidative stress-indicators, an increase was seen in the content of MDA (malondial dehyde), but the activity of SOD (superoxide dismutase) and content of GSH-PX (glutathione peroxidase) and CAT (catalase) were decreased; meanwhile, the protein expression of CBX7, HO-1, and nuclear Nrf2 was up-regulated, while the cytoplasmic Nrf2 was down-regulated. Moreover, CBX7 knockout attenuated I/R injury in mice. Conclusion Knockout of CBX7 may protect mice from cerebral I/R injury by reducing cell apoptosis and oxidative stress, possibly via activating the Nrf2/HO-1 pathway.

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Section: Discussionmentioning

confidence: 99%

RETRACTED: Neuroprotection of chromobox 7 knockout in the mouse after cerebral ischemia-reperfusion injury via nuclear factor E2-related factor 2/hemeoxygenase-1 signaling pathway

et al. 2021

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Protective effects of Shengmai San and its three fractions on cerebral ischemia-reperfusion injury

Wang

Kong

2013

Chinese Journal of Natural Medicines

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Isolation of a new triterpene derivative andin vitroandin vivoanticancer activity of ethanolic extract from root bark ofZizyphus nummulariaAubrev

Ray

Dewanjee

2014

Natural Product Research

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The various parts of Zizyphus nummularia has been used traditionally in several disease conditions. However, its anticancer activity and mechanism of action remain to be elucidated. Considering this, the objective of this study was to isolate, identify and screen for possible anticancer activity in vitro and in vivo of the ethanolic extract (EE) and isolated identified compound (IC) from Z. nummularia root bark. The in vitro activity against human breast cancer, leukaemia, ovarian cancer, colon adenocarcinoma and human kidney carcinoma cell lines was determined. The in vivo activity in female Swiss albino mice against Ehrlich ascites carcinoma (EAC) was determined. The isolated compound is a new triterpene derivative. EE/IC showed cytotoxicity against different cell lines. The administration of EE/IC decreased tumour parameters such as tumour volume, viable tumour cell count and increased body weight, haematological parameters and life span in comparison to the EAC control mice.

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Injectable Caltrop Fruit Saponin Protects Against Ischemia-Reperfusion Injury in Rat Brain

Cited by 6 publications

References 22 publications

RETRACTED: Neuroprotection of chromobox 7 knockout in the mouse after cerebral ischemia-reperfusion injury via nuclear factor E2-related factor 2/hemeoxygenase-1 signaling pathway

RETRACTED: Neuroprotection of chromobox 7 knockout in the mouse after cerebral ischemia-reperfusion injury via nuclear factor E2-related factor 2/hemeoxygenase-1 signaling pathway

Protective effects of Shengmai San and its three fractions on cerebral ischemia-reperfusion injury

Isolation of a new triterpene derivative andin vitroandin vivoanticancer activity of ethanolic extract from root bark ofZizyphus nummulariaAubrev

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