Injectable and Self-Healing Hydrogel Based on Chitosan-Tannic Acid and Oxidized Hyaluronic Acid for Wound Healing

Liu, Sixian; Jiang, Nian; Chi, Yuquan; Peng, Qiang; Dai, Guoru; Liu, Qian; Xu, Keming; Zhong, Wenying; Yue, Wanqing

doi:10.1021/acsbiomaterials.2c00321

Cited by 40 publications

(22 citation statements)

References 44 publications

(87 reference statements)

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“…The Schiff reaction is a chemical reaction involving a dy-namic covalent imine bond formation via the crosslinking of amine groups and aldehyde groups [ 112 ]. Taking into consideration that human tissues have a large number of amino groups, the aldehydes or ketones reaction further facilitates the binding of hydrogels with biological tissues.…”

Section: Preparation Of Cs Hydrogel and Its Application As Hemostatic...mentioning

confidence: 99%

“…Therefore, this new injectable and aerosolized hydrogel has good application prospects in the fields of hemostasis and wound dressing. Similarly, by reacting TA-modified CS with oxidized hyaluronic acid (OHA), Liu et al [ 112 ] prepared a composite CS hydrogel with hemostatic, adhesive, anti-inflammatory, and slow degradation properties. The CS/TA-OHA hydrogel exhibited good self-healing properties due to the presence of dynamic reversible covalent bonds and reversible hydrogen bonds.…”

Section: Preparation Of Cs Hydrogel and Its Application As Hemostatic...mentioning

confidence: 99%

“…( d ) Photographs of CS/TA-OHA adhering to organs and tissues of rats, and the amount of bleeding in rats under different treatments (* p < 0.05; *** p < 0.001.) [ 112 ]. Copyright 2022 American Chemical Society.…”

Section: Figurementioning

confidence: 99%

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Chitosan-Based Hemostatic Hydrogels: The Concept, Mechanism, Application, and Prospects

et al. 2023

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The design of new hemostatic materials to mitigate uncontrolled bleeding in emergencies is challenging. Chitosan-based hemostatic hydrogels have frequently been used for hemostasis due to their unique biocompatibility, tunable mechanical properties, injectability, and ease of handling. Moreover, chitosan (CS) absorbs red blood cells and activates platelets to promote hemostasis. Benefiting from these desired properties, the hemostatic application of CS hydrogels is attracting ever-increasing research attention. This paper reviews the recent research progress of CS-based hemostatic hydrogels and their advantageous characteristics compared to traditional hemostatic materials. The effects of the hemostatic mechanism, effects of deacetylation degree, relative molecular mass, and chemical modification on the hemostatic performance of CS hydrogels are summarized. Meanwhile, some typical applications of CS hydrogels are introduced to provide references for the preparation of efficient hemostatic hydrogels. Finally, the future perspectives of CS-based hemostatic hydrogels are presented.

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Section: Preparation Of Cs Hydrogel and Its Application As Hemostatic...mentioning

confidence: 99%

Section: Preparation Of Cs Hydrogel and Its Application As Hemostatic...mentioning

confidence: 99%

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Chitosan-Based Hemostatic Hydrogels: The Concept, Mechanism, Application, and Prospects

et al. 2023

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“…TA is easily oxidized (especially when pH > 7), and the phenolic hydroxyl group of the TA can form reversible covalent Schiff base (C�N) interactions with amines after being oxidized to quinone. 31 Therefore, the obtained N 1s energy spectra before and after LbL assembly were deconvolved to verify whether covalent bonds were generated. Since all the N elements are from Lyz, the variation in the composition of the N peaks in Lyz and (TA-Lyz) 6-pH coatings was detected.…”

Section: Quantification Of Water Contentmentioning

confidence: 99%

Role of Driving Force on Engineering Layer-by-Layer Protein/Polyphenol Coating with Flexible Structures and Properties

Zhao

et al. 2023

ACS Appl. Mater. Interfaces

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Protein-based coatings are of immense interest due to their rich biological functions. Layer-by-layer (LbL) assembly, as a powerful means of transferring protein functions to the material surface, has received widespread attention. However, the assembly mechanism of protein-based LbL coatings is still far from being explained, not only because of protein structure and function diversity but also characterization limitations. Herein, we monitored in situ the LbL assembly process of tannic acid (TA) and lysozyme (Lyz), a classic pair of polyphenol and protein, by combining quartz crystal microbalance with dissipation monitoring (QCM-D) and spectroscopic ellipsometry (SE). The water content, morphology, mechanical properties, antioxidant activity, and the driving force of TA-Lyz coating engineered under different pH values were analyzed in detail by various techniques. The water content, a key factor in TA-Lyz coatings, increased with increasing assembled pH values, which resulted in a porous morphology, inhomogeneous mechanical distribution, faster assembly growth, and better antioxidant activity in both acellular and cellular levels. In addition, high water content is unfavorable to both entropy and enthalpy changes, and the thermodynamic driving force of TA and Lyz assembly mainly comes from the enthalpy change brought by the noncovalent interaction between TA and Lyz. These results provide new insights into engineering the structure, function, and assembly mechanisms of protein-based coatings.

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“…HA has been found to be a promising candidate to promote wound healing by facilitating the inflammatory response, angiogenesis, and tissue regeneration processes. 13,14 Collagen is a key component of the skin's ECM and is essential for dermal collagen fibrillogenesis and tissue integrity. 15,16 However, collagen has some limitations in tissue engineering applications, including its immunogenicity and low efficiency.…”

Section: Introductionmentioning

confidence: 99%

Collagen–Hyaluronic Acid Composite Hydrogels with Applications for Chronic Diabetic Wound Repair

Liang,

Dong,

Guo

et al. 2023

ACS Biomater. Sci. Eng.

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Chronic diabetic wounds have become a major healthcare challenge worldwide. Improper treatment may lead to serious complications. Current treatment methods including biological and physical methods and skin grafting have limitations and disadvantages, such as poor efficacy, inconvenience of use, and high cost. Therefore, developing a more effective and feasible treatment is of great significance for the repair of chronic diabetic wounds. Hydrogels can be designed to serve multiple functions to promote the repair of chronic diabetic wounds. Furthermore, 3D bioprinting enables hydrogel customization to fit chronic diabetic wounds, thus facilitating the healing process. This paper reports a study of 3D printing of a collagen−hyaluronic acid composite hydrogels with application for chronic diabetic wound repair. In situ printed hydrogels were developed by a macromolecular crosslinking network using methacrylated recombinant human collagen (RHCMA) and methacrylated hyaluronic acid (HAMA), both of which can respond to ultraviolet (UV) irradiation. The hydrogels were also loaded with silver nanoclusters (AgNCs) with ultra-small-size nanoparticles, which have the advantages of deep penetration ability and broad-spectrum high-efficiency antibacterial properties. The results of this study show that the developed RHCMA, HAMA, and AgNCs (RHAg) composite hydrogels present good UV responsiveness, porosity, mechanical properties, printability, and biocompatibility, all of which are beneficial to wound healing. The results of this study further show that the developed RHAg hydrogels not only effectively inhibited Staphylococcus aureus and Pseudomonas aeruginosa but also promoted the proliferation and migration of fibroblasts in vitro and tissue regeneration and collagen deposition in vivo, thus producing a desirable wound repair effect and can be used as an effective functional biomaterial to promote chronic diabetic wound repair.

show abstract

Injectable and Self-Healing Hydrogel Based on Chitosan-Tannic Acid and Oxidized Hyaluronic Acid for Wound Healing

Cited by 40 publications

References 44 publications

Chitosan-Based Hemostatic Hydrogels: The Concept, Mechanism, Application, and Prospects

Chitosan-Based Hemostatic Hydrogels: The Concept, Mechanism, Application, and Prospects

Role of Driving Force on Engineering Layer-by-Layer Protein/Polyphenol Coating with Flexible Structures and Properties

Collagen–Hyaluronic Acid Composite Hydrogels with Applications for Chronic Diabetic Wound Repair

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