Injectable and NIR‐Responsive DNA–Inorganic Hybrid Hydrogels with Outstanding Photothermal Therapy

Liu, Bin; Sun, Jing; Zhu, Junjie; Li, Bo; Ma, Chao; Gu, Xinquan; Li, Kai; Zhang, Hongjie; Wang, Fan; Su, Juanjuan; Yang, Yang

doi:10.1002/adma.202004460

Cited by 127 publications

(113 citation statements)

References 42 publications

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“…Photothermal agents can convert light energy to heat under near infrared (NIR) irradiation [ 28 , 29 ]. The target temperature of photothermal hydrogels can be adjusted by changing the concentration and proportion of photothermal agents, irradiation time, and laser intensity [ 30 ]. Mild local heat (41 °C–43 °C) can promote cell proliferation, angiogenesis, wound healing, and bone regeneration [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Zhang

Tan

et al. 2021

Polymers

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Photothermal treatment (PTT) is a promising strategy to deal with multidrug-resistant bacteria infection and promote tissue regeneration. Previous studies demonstrated that hyperthermia can effectively inhibit the growth of bacteria, whereas mild heat can promote cell proliferation, further accelerating wound healing and bone regeneration. Especially, hydrogels with photothermal properties could achieve remotely controlled drug release. In this review, we introduce a photothermal agent hybrid in hydrogels for a photothermal effect. We also summarize the potential mechanisms of photothermal hydrogels regarding antibacterial action, angiogenesis, and osteogenesis. Furthermore, recent developments in photothermal hydrogels in wound healing and bone regeneration applications are introduced. Finally, future application of photothermal hydrogels is discussed. Hydrogels with photothermal effects provide a new direction for wound healing and bone regeneration, and this review will give a reference for the tissue engineering.

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Section: Introductionmentioning

confidence: 99%

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Zhang

Tan

et al. 2021

Polymers

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“…An 808 nm laser was used for this system due to the low absorption of water and a strong tissue penetration and low side effects in vivo. [27,30] To study this photothermal effect, the E 72 -Chitosan-Ag 3 AuS 2 hydrogel with different concentrations of inorganic NPs was investigated. The higher concentration of Ag 3 AuS 2 NPs in the system resulted in faster heating and higher temperature in a very short time (Figure 3A and Figure S10, Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

Engineered Protein Photo‐Thermal Hydrogels for Outstanding In Situ Tongue Cancer Therapy

Lü

Jiang

et al. 2021

Advanced Materials

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Surgical excision is the main choice for tongue cancer treatment. However, the physiological functions of oral and maxillofacial regions might be severely impaired and high risk of tongue tumor recurrence cannot be avoided. It is thus becoming urgently important to develop alternative strategies for tongue cancer therapy. In this regard, a new class of near‐infrared (NIR) light‐responsive and peritumoral injectable hydrogel is fabricated with extraordinary photothermal therapy (PTT) for in situ tongue tumors. The as‐prepared soft material exhibits good biocompatibility and ultra‐strong photothermal effect due to the formed network by negatively charged proteins, chitosan molecules, and Ag3AuS2 nanoparticles (NPs). In a well‐constructed in situ tongue tumor model, tumors can be efficiently eradicated by one‐time PTT treatment. Importantly, there are no side effects on surrounding normal tissues and potential tumor recurrence is inhibited. In stark contrast to traditional surgical excision, such biomaterials hold great potential for clinical treatment of oral cancers.

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“…In recent years, in order to maximize the efficiency of drug delivery, local therapy has received widespread attention. [ 12–14 ] Compared with oral administration and intravenous injection, local minimally invasive administration can directly deliver agents into the tumor site through a controlled manner, which can greatly reduce the drug dose, thus sparing the off‐target toxicity. [ 14 ] However, the clinical translation of local therapy is still impeded by many well‐known challenges: i) short retention time of therapeutic agents, [ 7 ] ii) poor uptake of anticancer therapies by drug‐resistant tumor cells, and iii) difficulty in realizing responsive multi‐modal therapy.…”

Section: Introductionmentioning

confidence: 99%

Peritumoral Microgel Reservoir for Long‐Term Light‐Controlled Triple‐Synergistic Treatment of Osteosarcoma with Single Ultra‐Low Dose

Yan

Wang

Ran

et al. 2021

Small

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Local minimally invasive injection of anticancer therapies is a compelling approach to maximize the utilization of drugs and reduce the systemic adverse drug effects. However, the clinical translation is still hampered by many challenges such as short residence time of therapeutic agents and the difficulty in achieving multi‐modulation combination therapy. Herein, mesoporous silica‐coated gold nanorods (AuNR@SiO2) core‐shell nanoparticles are fabricated to facilitate drug loading while rendering them photothermally responsive. Subsequently, AuNR@SiO2 is anchored into a monodisperse photocrosslinkable gelatin (GelMA) microgel through one‐step microfluidic technology. Chemotherapeutic drug doxorubicin (DOX) is loaded into AuNR@SiO2 and 5,6‐dimethylxanthenone‐4‐acetic acid (DMXAA) is loaded in the microgel layer. The osteosarcoma targeting ligand alendronate is conjugated to AuNR@SiO2 to improve the tumor targeting. The microgel greatly improves the injectability since they can be dispersed in buffer and the injectability and degradability are adjustable by microfluidics during the fabrication. The drug release can, in turn, be modulated by multi‐round light‐trigger. Importantly, a single super low drug dose (1 mg kg−1 DOX with 5 mg kg−1 DMXAA) with peritumoral injection generates long‐term therapeutic effect and significantly inhibited tumor growth in osteosarcoma bearing mice. Therefore, this nanocomposite@microgel system can act as a peritumoral reservoir for long‐term effective osteosarcoma treatment.

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Injectable and NIR‐Responsive DNA–Inorganic Hybrid Hydrogels with Outstanding Photothermal Therapy

Cited by 127 publications

References 42 publications

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Engineered Protein Photo‐Thermal Hydrogels for Outstanding In Situ Tongue Cancer Therapy

Peritumoral Microgel Reservoir for Long‐Term Light‐Controlled Triple‐Synergistic Treatment of Osteosarcoma with Single Ultra‐Low Dose

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