Injectable adhesive hemostatic gel with tumor acidity neutralizer and neutrophil extracellular traps lyase for enhancing adoptive NK cell therapy prevents post-resection recurrence of hepatocellular carcinoma

Cheng, Yusheng; Gong, Yihang; Chen, Xiuxing; Zhang, Qi; Zhang, Xijian; He, Yizhan; Pan, Longfa; Ni, Beibei; Yang, Fan; Xu, Yan; Zhou, Lei; Yang, Yang; Chen, Wenjie

doi:10.1016/j.biomaterials.2022.121506

Cited by 43 publications

(39 citation statements)

References 51 publications

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“…In vitro, NETs inhibited migration and motility of NK cells indicating a direct effect of NETs (61). In a NET-rich TIME the therapeutic efficiency of NK cells was clearly impaired (135). Moreover, the inhibition of NETs in a murine model of HCC enhanced the anti-tumor immunity mediated by NK cells (135).…”

Section: Nets Impair the Anti-tumor Effects Of Nk Cellsmentioning

confidence: 97%

“…In addition, surgery was found to stimulate NET formation and exacerbated distal organ injury by the activation of a systemic procoagulant state and diffuse microvascular immune thrombi (132)(133)(134). Clinical trials showed convincing therapeutic effects of NK cell infusion in various hematological malignancies (135). However, NET-coated tumor spheroids protected tumor cells from cytotoxicity of NK cells (61).…”

Section: Nets Impair the Anti-tumor Effects Of Nk Cellsmentioning

confidence: 99%

“…In a NET-rich TIME the therapeutic efficiency of NK cells was clearly impaired (135). Moreover, the inhibition of NETs in a murine model of HCC enhanced the anti-tumor immunity mediated by NK cells (135). Besides physical shielding tumor cells from attacks of NK cells, further mechanisms may exist that impair the anti-tumor function of NK cells.…”

Section: Nets Impair the Anti-tumor Effects Of Nk Cellsmentioning

confidence: 99%

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No NETs no TIME: Crosstalk between neutrophil extracellular traps and the tumor immune microenvironment

et al. 2022

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The tumor immune microenvironment (TIME) controls tumorigenesis. Neutrophils are important components of TIME and control tumor progression and therapy resistance. Neutrophil extracellular traps (NETs) ejected by activated neutrophils are net-like structures composed of decondensed extracellular chromatin filaments decorated with a plethora of granules as well as cytoplasmic proteins. Many of these harbour post translational modifications. Cancer cells reportedly trigger NET formation, and conversely, NETs alter the TIME and promote tumor cell proliferation and migration. The specific interactions between NETs and TIME and the respective effects on tumor progression are still elusive. In certain tumors, a CD4+ T helper (Th) 2 cell-associated TIME induces NETs and exerts immunosuppressive functions via programmed death 1 (PD-1)/PD-L1, both associated with poorer prognosis. In other cases, NETs induce the proliferation of Th1 cells, associated with an improved prognosis in cancer. In addition, NETs can drive macrophage polarization and often rely on macrophages to promote cancer cell invasion and metastasis. In turn, macrophages can swiftly clear NETs in an immunologically silent manner. The aim of this review is to summarize the knowledge about the mutual interaction between NETs and TIME and its impact on tumor growth and therapy.

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Section: Nets Impair the Anti-tumor Effects Of Nk Cellsmentioning

confidence: 97%

Section: Nets Impair the Anti-tumor Effects Of Nk Cellsmentioning

confidence: 99%

Section: Nets Impair the Anti-tumor Effects Of Nk Cellsmentioning

confidence: 99%

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No NETs no TIME: Crosstalk between neutrophil extracellular traps and the tumor immune microenvironment

et al. 2022

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“…Chen et al constructed a photoregulated DNase I delivery system based on DNase I-loaded nanoparticles that were able to release the enzyme in the case of laser irradiation, and in combination therapy with anti-PD-1 therapy they showed synergistic enhanced anti-tumor effects based on tumor burden and survival rates [ 328 ]. Cheng et al developed a DNase I-loading hydrogel with a tumor acidity neutralizer and demonstrated in an HCC mouse model that local hydrogel application after HCC resection in combination with NK infusion therapy prevented HCC recurrence [ 329 ].…”

Section: Neutrophil In Cancer Therapy: Potential Strategiesmentioning

confidence: 99%

Diverse Neutrophil Functions in Cancer and Promising Neutrophil-Based Cancer Therapies

Sounbuli

Миронова

Alekseeva

2022

IJMS

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Neutrophils represent the most abundant cell type of leukocytes in the human blood and have been considered a vital player in the innate immune system and the first line of defense against invading pathogens. Recently, several studies showed that neutrophils play an active role in the immune response during cancer development. They exhibited both pro-oncogenic and anti-tumor activities under the influence of various mediators in the tumor microenvironment. Neutrophils can be divided into several subpopulations, thus contradicting the traditional concept of neutrophils as a homogeneous population with a specific function in the innate immunity and opening new horizons for cancer therapy. Despite the promising achievements in this field, a full understanding of tumor–neutrophil interplay is currently lacking. In this review, we try to summarize the current view on neutrophil heterogeneity in cancer, discuss the different communication pathways between tumors and neutrophils, and focus on the implementation of these new findings to develop promising neutrophil-based cancer therapies.

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“…Cheng Y et al. demonstrated that combination of NK cell adoptive therapy and hydrogel-based delivery system can destruct NETs and prevent post-resection and post liver transplantation HCC recurrence ( 143 ). NETs play an integral role in cancer invasion, transport, and transendothelial migration according to a multilevel model, especially in HCC recurrence should be further studied.…”

Section: Nets and Hepatocellular Carcinoma Recurrencementioning

confidence: 99%

Neutrophil extracellular traps and complications of liver transplantation

et al. 2022

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Many end-stage liver disease etiologies are attributed to robust inflammatory cell recruitment. Neutrophils play an important role in inflammatory infiltration and neutrophil phagocytosis, oxidative burst, and degranulation. It has also been suggested that neutrophils may release neutrophil extracellular traps (NETs) to kill pathogens. It has been proven that neutrophil infiltration within the liver contributes to an inflammatory microenvironment and immune cell activation. Growing evidence implies that NETs are involved in the progression of numerous complications of liver transplantation, including ischemia-reperfusion injury, acute rejection, thrombosis, and hepatocellular carcinoma recurrence. NETs are discussed in this comprehensive review, focusing on their effects on liver transplantation complications. Furthermore, we discuss NETs as potential targets for liver transplantation therapy.

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Injectable adhesive hemostatic gel with tumor acidity neutralizer and neutrophil extracellular traps lyase for enhancing adoptive NK cell therapy prevents post-resection recurrence of hepatocellular carcinoma

Cited by 43 publications

References 51 publications

No NETs no TIME: Crosstalk between neutrophil extracellular traps and the tumor immune microenvironment

No NETs no TIME: Crosstalk between neutrophil extracellular traps and the tumor immune microenvironment

Diverse Neutrophil Functions in Cancer and Promising Neutrophil-Based Cancer Therapies

Neutrophil extracellular traps and complications of liver transplantation

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