Injectable adhesive carboxymethyl chitosan-based hydrogels with self-mending and antimicrobial features for the potential management of periodontal diseases

Abstract

The CPM hydrogels fabricated in this work display injectability, structural stability, and high tissue adhesion in the wet and motional state, as well as self-healing features.

Self-healing, injectable chitosan-based hydrogels: structure, properties and biological applications

“…Often pH-responsive drug release is induced in applications or gastrointestinal and Periodontal Diseases. 201 Additionally, selfhealing hydrogels can be combined with other technologies, such as nanoparticles 232,233 or microneedles, 234,235 to further enhance drug delivery capabilities. 153 Marapureddy et al 2022 induced nanosheets of graphene oxide to improve the mechanical strength and to obtain a pH-responsive sustained drug release.…”

“…Additionally, CMCS holds the potential for drug delivery to wet tissues in oral diseases. 201 Other than the above applications, it can be used in nerve regeneration which is a gradual process involving the disconnection of nerve sheaths and underlying neurons. To expedite healing and regeneration, external assistance is required.…”

Comparative study on the effects of different polishing methods on tooth surface microstructure and roughness following initial periodontal treatment

“…Periodontal scaling and curettage of supragingival and subgingival areas and sandblasting are the most important procedures (Lin et al, 2023); however, there are many reports suggesting that basic treatment removes plaque and increases the surface roughness of teeth (Benfenati et al, 1987;Bühler et al, 2016;Caygur et al, 2017).…”

“…To date, a common method for removing and controlling plaque involves a basic treatment with supportive therapy for periodontitis. Periodontal scaling and curettage of supragingival and subgingival areas and sandblasting are the most important procedures (Lin et al, 2023 ); however, there are many reports suggesting that basic treatment removes plaque and increases the surface roughness of teeth (Benfenati et al, 1987 ; Bühler et al, 2016 ; Caygur et al, 2017 ). In clinical work, polishing in periodontitis cases after scaling and curettage includes silicon onegloss and rubber cup polishing, which improves the surface smoothness of teeth, reduces the adhesion of bacteria and food residue, and slows the rate of reformation of dental calculus (Oda et al, 2004 ).…”