Injectability and Tissue Compatibility of Poly-(N-Vinyl-2-Pyrrolidone) in the Skin of Rats: A Pilot Study

Abstract

Poly-(N-vinyl-2-pyrrolidone) is easy to inject intracutaneously and is well tolerated in the rat model. Short-term volume retention is good. Histopathology suggests a subclinical inflammatory reaction expected with implantation of a synthetic substance into the skin. Additional studies are necessary to investigate the continued persistence of the hydrogel and its long-term effects on surrounding tissue.

Validation of a Small Animal Model for Soft Tissue Filler Characterization

“…[20][21][22] Marler and colleagues used a dorsal subcutaneous injection model to compare the histo-morphometry of three forms of a calcium alginate hydrogel for 8 weeks. [20][21][22] Marler and colleagues used a dorsal subcutaneous injection model to compare the histo-morphometry of three forms of a calcium alginate hydrogel for 8 weeks.…”

“…[20][21][22] Marler and colleagues used a dorsal subcutaneous injection model to compare the histo-morphometry of three forms of a calcium alginate hydrogel for 8 weeks. 21 Fernandez-Cossio studied the biocompatibility of a HA filler (Perlane) and polyacrylamide gel filler (Aquamid) at four time points in an 8-month study, 22 but only Marler and colleagues reported assessment of volume change over time as an outcome measure. 21 Fernandez-Cossio studied the biocompatibility of a HA filler (Perlane) and polyacrylamide gel filler (Aquamid) at four time points in an 8-month study, 22 but only Marler and colleagues reported assessment of volume change over time as an outcome measure.…”

“…A few studies of subcutaneous filler or hydrogel injections in a rat model have been published in the literature. [20][21][22] Marler and colleagues used a dorsal subcutaneous injection model to compare the histo-morphometry of three forms of a calcium alginate hydrogel for 8 weeks. 20 Arpey used a similar model to assess the injectability and biocompatibility of poly-(N-vinyl-2-pyrrolidone) for 12 weeks.…”

“…20 Arpey used a similar model to assess the injectability and biocompatibility of poly-(N-vinyl-2-pyrrolidone) for 12 weeks. 21 Fernandez-Cossio studied the biocompatibility of a HA filler (Perlane) and polyacrylamide gel filler (Aquamid) at four time points in an 8-month study, 22 but only Marler and colleagues reported assessment of volume change over time as an outcome measure. 20 Marler and colleagues followed volume ratio over a 2-month time course in evaluating injectable hydrogels in a rat model, but to our knowledge, no published study has evaluated long-term volume retention at regular intervals.…”