Initiative for Early Lung Cancer Research on Treatment: Development of Study Design and Pilot Implementation

Flores, Raja M.; Taioli, Emanuela; Yankelevitz, David F.; Becker, Betsy Jane; Jirapatnakul, Artit; Reeves, Anthony P.; Yip, Rowena; Fevrier, E.; Tam, Kathleen; Steiger, Benjamin; Henschke, Claudia I.; Kaufman, Andrew; Lee, Dong‐Seok; Nicastri, Daniel G.; Wolf, Andrea; Rosenzweig, Kenneth E.; Gomez, Jorge; Beasley, Mary Beth; Zakowski, Maureen F.; Chung, Michael; Futamura, Rita; Kantor, Sydney; Wallace, Carly; Bhora, Faiz Y.; Raad, Wissam; Evans, Andrew; Choi, Walter; Buyuk, Zrzu; Friedman, Adie; Dreifuss, Ronald; Verzosa, Stacey; Yakubox, Mariya; Aloferdova, Karina; Stacey, Patricia; Nobrega, Simone De; Hakami, Ardeshir; Pass, Harvey I.; Crawford, Berne; Donnington, Jessica; Cooper, Benjamin; Moreirea, Andre; Sorensen, Audrey; Kohman, Leslie J.; Dunton, Robert F.; Wallen, Jason; Curtiss, Christopher; Scalzetti, Ernest M.; Ellinwood, L. E.; Aye, Ralph W.; Vallières, Eric; Louie, Brian E.; Frivar, Alex; Mehta, Vivek; Manning, Kristin; Chona, Maria; Smith, Andrew H.; Connery, Clifford P.; Torres, Emilo; Cruzer, Dan; Gendron, Bruce; Alyea, Sonya; Lackaye, Daniel; Studer, Lauren

doi:10.1016/j.jtho.2018.03.009

Cited by 20 publications

(14 citation statements)

References 46 publications

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“…In 2016, a prospective cohort study of documented Stage I NSCLC patients receiving surgical, radiotherapy, or other treatment [the Initiative for Early Lung Cancer Research on Treatment (IELCART)] was started (17) in order to assess treatment differences in the course of clinical care by documenting the QoL measures before and after surgery to identify critical time points at which supportive interventions (e.g., additional social support, physical therapy) would be most helpful.…”

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confidence: 99%

Change in quality of life of stage IA lung cancer patients after sublobar resection and lobectomy

et al. 2020

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Background: Few studies have examined the differential impact of sublobar resection (SL) and lobectomy (L) on quality of life (QoL) during the first postoperative year. Methods:We used a prospective cohort of Stage IA lung cancer patients undergoing video-assisted thoracoscopic surgery (VATS) from the Initiative for Early Lung Cancer Research on Treatment. QoL was measured before surgery, and within 4, 6, and 12 months post-surgery using three validated instruments: SF-12 [physical (PCS) and mental health (MCS)], FACT-LCS (lung-cancer-symptoms), and the PHQ-4 (anxiety and depression subscales). Locally weighted smoothing curve (LOWESS) was fitted to identify the best interval knot for the change in the QoL trend post-surgery. After adjusting for demographic and clinical variables, an adjusted piecewise linear mixed effects model was developed to estimate differences in baseline and 12-month scores, and rates of change for each QoL measure. Results: SL resection was performed in 127 (63.2%) and L in 74 (36.8%) patients. LOWESS plots suggested that the shift of QoL (interval knot) was at 2 months post-surgery. Decreases in PCS scores were less severe for SL than L patients 2 months post-surgery (−0.18 vs. −2.30, P=0.02); while subsequent improvements were observed for both groups (SL: +0.

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Section: Introductionmentioning

confidence: 99%

Change in quality of life of stage IA lung cancer patients after sublobar resection and lobectomy

et al. 2020

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“…[12][13][14] Smokers recruited in lung cancer screening show a heterogeneous range of concurrent causes of death, including multifocal thoracic malignancies, extrapulmonary cancer, and non-neoplastic disease. 15,16 The resection of a slow-growing lung cancer might result in no clinical advantage or even detrimental effects for a subject with such comorbidities. 17,18 Since 2005, the Multicenter Italian Lung Detection (MILD) study protocol implemented a prospective conservative approach to SSN, by long-term active surveillance.…”

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confidence: 99%

Long-Term Active Surveillance of Screening Detected Subsolid Nodules is a Safe Strategy to Reduce Overtreatment

Silva

Prokop

Jacobs

et al. 2018

Journal of Thoracic Oncology

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“…Multiple non‐inferiority randomized trials comparing sublobar resection to lobectomy are ongoing, but are not expected to result for several years. We hypothesized that segmentectomy is not inferior to lobectomy for the treatment of early stage lung cancer 5‐7 …”

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confidence: 99%

Outcomes of superior segmentectomy versus lower lobectomy for superior segment Stage I non‐small‐cell lung cancer are equivalent: An analysis of 196 patients at a single, high volume institution

Dolan

White

Mazzola

et al. 2020

Journal of Surgical Oncology

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ObjectivesTo determine if superior segmentectomy has equivalent overall (OS), disease‐free (DFS), and locoregional‐recurrence‐free survival (LRFS) to lower lobectomy for early‐stage non‐small‐cell lung cancer (NSCLC) in the superior segment.MethodsWe retrospectively reviewed all Stage 1 lower lobectomies for superior segment lesions and superior segmentectomies at our hospital from 2000 to 2018. Comparison statistics and Cox hazard modeling were performed to determine differences between groups and attempt to identify risk factors for OS, DFS, and LRFS.ResultsSuperior segmentectomy patients, compared with lower lobectomy patients, had more current smokers, worse forced expiratory volume in 1 s percentage, radiologic emphysema scores, clinically and pathologically smaller tumors, and more occurrences of 0 lymph nodes examined. Outcomes for superior segmentectomy compared with lower lobectomy were equivalent for 5‐year OS (67.0% vs. 75.1%, p = 0.70), DFS (56.9% vs. 60.4%, p = 0.59), and LRFS (87.9% vs. 91.3%, p = 0.46). Multivariable Cox modeling lacked utility due to no outcome differences.ConclusionsIn well‐selected patients, superior segmentectomies can have equivalent OS, DFS, and LRFS compared with lower lobectomies of superior segment tumors for early stage lung cancer. Further data are needed to provide better risk estimates.

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Initiative for Early Lung Cancer Research on Treatment: Development of Study Design and Pilot Implementation

Abstract: It was feasible to obtain pre- and postsurgical information from patients and surgeons. We anticipate statistically meaningful results about treatment alternatives in 3 to 5 years.

Cited by 20 publications

References 46 publications

Change in quality of life of stage IA lung cancer patients after sublobar resection and lobectomy

Change in quality of life of stage IA lung cancer patients after sublobar resection and lobectomy

Long-Term Active Surveillance of Screening Detected Subsolid Nodules is a Safe Strategy to Reduce Overtreatment

Outcomes of superior segmentectomy versus lower lobectomy for superior segment Stage I non‐small‐cell lung cancer are equivalent: An analysis of 196 patients at a single, high volume institution

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