Initiation Patterns and Trends of E-Cigarette and Cigarette Use Among U.S. Adolescents

Evans-Polce, Rebecca J.; Veliz, Philip; McCabe, Sean Esteban

doi:10.1016/j.jadohealth.2019.07.002

Cited by 20 publications

(13 citation statements)

References 30 publications

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“…Veliz et al [10] used data from the Population Assessment of Tobacco and Health across three time points (from 2015 to 2016) to show that most adolescents using e-cigarettes in the past 30 days had previously never used any other tobacco products. Evans-Polce et al [11] using Monitoring the Future data (2015e2017) similarly find that compared with cigarettes, more adolescents were initiating tobacco with e-cigarettes instead of cigarettes. Data from the 2015 to 2017 National Youth Tobacco Survey, studied by Odani et al [12], showed that e-cigarette users were three times more likely to go on to use cigarettes.…”

Section: Editorialmentioning

confidence: 97%

Escalating Safety Concerns Are Not Changing Adolescent E-Cigarette Use Patterns: The Possible Role of Adolescent Mental Health

Gaiha

Halpern‐Felsher

2020

Journal of Adolescent Health

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Section: Editorialmentioning

confidence: 97%

Escalating Safety Concerns Are Not Changing Adolescent E-Cigarette Use Patterns: The Possible Role of Adolescent Mental Health

Gaiha

Halpern‐Felsher

2020

Journal of Adolescent Health

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“…The spread of the e-cigarette market has been rapid, despite many unanswered questions about their safety, efficacy in reducing dependence, and overall impact on public health. At present, a wide range of people across demographics consume e-cigarettes, including individuals who were not previously tobacco smokers ( Adkison et al, 2013 ; Grana et al, 2014 ), and these numbers have dramatically risen in more recent years, especially among youth ( Evans-Polce et al, 2020 ). Previous studies have shown that lung inflammation and suppression of the immune response are found following exposure to a variety of chemicals in e-cigarette vapor, including nicotine ( Lerner et al, 2015 ; Wang et al, 2019 ; Wu et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

E-cigarette vape and lung ACE2 expression: Implications for coronavirus vulnerability

Lallai

Manca

Fowler

2021

Environmental Toxicology and Pharmacology

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Evidence in humans suggests a correlation between nicotine smoking and severe respiratory symptoms with COVID-19 infection. In lung tissue, angiotensin-converting enzyme 2 (ACE2) appears to mechanistically underlie viral entry. Here, we investigated whether e-cigarette vapor inhalation alters ACE2 and nicotinic acetylcholine receptor (nAChR) expression in male and female mice. In male lung, nicotine vapor inhalation induced a significant increase in ACE2 mRNA and protein, but surprisingly, these differences were not found in females. Further, both vehicle and nicotine vapor inhalation downregulated α5 nAChR subunits in both sexes, while differences were not found in α7 nAChR subunit expression. Finally, blood ACE2 levels did not differ with exposure, indicating that blood sampling is not a sufficient indicator of lung ACE2 changes. Together, these data indicate a direct link between e-cigarette vaping and increased ACE2 expression in male lung tissue, which thereby reveals an underlying mechanism of increased vulnerability to coronavirus infection in individuals vaping nicotine.

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“…However, national surveys do not suggest any gateway effect. Studies from the USA (288,302,317), UK, New Zealand (318) and Canada (319), have concluded that (i) smoking usually precedes vaping; (ii) regular vaping is rare amongst never smokers;…”

Section: Vapers Demographics -Uptake By Young People and Potential Gateway Effectsmentioning

confidence: 99%

Evidence From the Scientific Assessment of Electronic Cigarettes and Their Role in Tobacco Harm Reduction

Camacho

Ebajemito

Coburn

et al. 2021

Contributions to Tobacco &Amp; Nicotine Research

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Summary While smoking remains a main global cause of preventable morbidity and mortality, a potential inflection point has arrived where it could become possible for non-combustible nicotine products to displace cigarettes and reduce risk for smokers who transition completely from smoking. These have proven consumer satisfaction and are now widely and increasingly available globally. One of the most prominent of these nicotine products are electronic cigarettes (ECs), which are used daily by millions of current and former smokers. The category is not without controversy as these products are not risk free and can cause nicotine dependence. The differing interpretation of science assessing ECs has transpired into inconsistent regulation and product standards, providing an environment for its fragmented manufacturing base which allows for variable product quality and in turn, product quality variability has impacted on how they are viewed. In this review, we assess published scientific evidence to evaluate whether, on balance, ECs fulfil a tobacco harm reduction role by reducing health risks relative to smoking and providing a viable alternative for smokers while having limited appeal to non-smokers.

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Initiation Patterns and Trends of E-Cigarette and Cigarette Use Among U.S. Adolescents

Cited by 20 publications

References 30 publications

Escalating Safety Concerns Are Not Changing Adolescent E-Cigarette Use Patterns: The Possible Role of Adolescent Mental Health

Escalating Safety Concerns Are Not Changing Adolescent E-Cigarette Use Patterns: The Possible Role of Adolescent Mental Health

E-cigarette vape and lung ACE2 expression: Implications for coronavirus vulnerability

Evidence From the Scientific Assessment of Electronic Cigarettes and Their Role in Tobacco Harm Reduction

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