2006
DOI: 10.1182/blood-2006-02-001073
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Initiation of plasminogen activation on the surface of monocytes expressing the type II transmembrane serine protease matriptase

Abstract: uPA (urokinase-type plasminogen activator) activates plasminogen with high efficiency when bound to its cellular receptor uPAR, but only after a prolonged lag phase during which generated plasmin activates pro-uPA. How the activity of this proteolytic system might be rapidly initiated is unknown. We have now found that 2 monocytic cell lines display distinct patterns of plasminogen activation. U937 cells, but not THP-1 cells, displayed the expected lag phase, suggesting a constitutive initiation mechanism on t… Show more

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Cited by 101 publications
(115 citation statements)
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“…ticipate in immune response (6,7). Indeed, knockdown studies in mice have shown that matriptase is important in postnatal survival, the development of the epidermis, hair follicles, and cellular immune system (8).…”
mentioning
confidence: 99%
“…ticipate in immune response (6,7). Indeed, knockdown studies in mice have shown that matriptase is important in postnatal survival, the development of the epidermis, hair follicles, and cellular immune system (8).…”
mentioning
confidence: 99%
“…HAI-1 might prevent the self-degradation of matriptase in the intracellular environment. It has been shown that matriptase is not co-expressed with HAI-1 in certain cell types and cultured cells (e.g., in ovary granulosa cells and in human monocyte THP-1 cells) (Szabo et al 2008;Kilpatrick et al 2006). In addition, genetic studies using zebrafish indicated that matriptase does not require HAI-1 for biological activity (i.e., for extracellular occurrence) (Carney et al 2007;Mathias et al 2007).…”
Section: Discussionmentioning
confidence: 99%
“…For example, TMPRSS4 upregulates uPA expression and activation in the DU145 prostate cancer and the NCI-H322 lung cancer cell lines by a mechanism involving modulation of the ERK signaling pathway (23). Matriptase is also able to activate pro-UPA in the ovarian cancer cell line HRA (29) and the monocytic leukemia cell line THP-1 (22). On the other hand, induction of invasive and migratory capacities of PANC-1 cells has been linked to activation of ERK by phosphorylation (30).…”
Section: Discussionmentioning
confidence: 99%
“…Different reports have emphasized the pro-tumor activities of different TTSPs in pancreatic cancer (9,20,21). Activation (22) or upregulation (23) of pro-uPA may underlie the pro-tumor effects caused by these serine proteases. In the present study, we investigated the effects of the exogenous expression of polyserase-1 in pancreas-derived tumor cells (24,25).…”
Section: Introductionmentioning
confidence: 99%