Initiation of oogenesis and meiosis in the fetal ovary depends on Dennd1a-mediated production of Wnt5a and retinoic acid from the somatic niches

Shi, Juanjuan; Niu, Qun; Gao, Qing; Fu, Jiang; Ma, Jinlong

doi:10.52586/5045

Cited by 1 publication

(1 citation statement)

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“…Dennd1a, which is mainly expressed in somatic cells in the ovaries of mouse fetuses, is essential for oogenesis. Its disruption results in a significant reduction in germ cell number [62]. Thus, although the structure of the mammalian ovary is different from that of Drosophila, they share a common phenomenon wherein the niche forms and controls GC proliferation during ovary development.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Niche formation and function in developing tissue: studies from the Drosophila ovary

Jin

Zhao

2023

Cell Commun Signal

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Adult stem cells have a unique ability to self-renew and to generate differentiated daughter cells that are required in the body tissues. The identity of adult stem cells is maintained by extrinsic signals from other cell types, known as niche cells. Thus, the niche is required for appropriate tissue homeostasis. Niche is formed and recruits stem cells during tissue development; therefore, it is essential to establish niche cells and stem cells in proper numbers during development. A small niche may recruit too few stem cells and cause tissue degeneration, while a large niche may maintain too many stem cells and lead to tumorigenesis. Given that vertebrate tissues are not suitable for large-scale forward genetics studies, the Drosophila ovary stands out as an excellent model for studying how multiple niche cell types and germ cells (GCs) are coordinately regulated in vivo. Recent studies are beginning to reveal how various signaling molecules regulate niche formation and how niche cells non-autonomously influence GC number. In this review, we summarize the ovarian niche structure, the key signaling pathways for niche formation, and how niche cells generate extrinsic factors to control GC proliferation during ovarian development.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%