Initiation of Follicular Growth in the Infant Mouse Ovary by Exogenous Gonadotrophin

Lintern‐Moore, Sue

doi:10.1095/biolreprod17.5.635

Cited by 31 publications

(14 citation statements)

References 15 publications

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“…Furthermore since several authors have now claimed that the early stages of follicle growth are gonadotrophin dependent (Ryle, 1972 ;de Reviers and Maul6on, 1973 ;Lintern-Moore, 1977) Our quantitative study of the follicular population in two strains of rats confirms the work of Peters (1969) in the mouse suggesting a constructive phase followed by a regressive phase. However it is interesting to consider the factors that influence the evolution of the follicular population because although large differences initially appear in this evolution (between 12 and 20 days of age), the final populations are similar in both strains at 32 days of age which is just prior to puberty.…”

supporting

confidence: 75%

Evolution of ovarian follicular population and serum gonadotrophins in the prepubertal period of two strains of rats

Reviers¹,

Mauléon²

1979

Ann. Biol. anim. Bioch. Biophys.

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This is a surprising finding since FSH is known to stimulate follicular growth and, despite the high concentrations, the follicular population is poorly developed in strain 12.A lack of development of FSH receptors in strain 12 rats at the early stage of follicular growth seems to be the more plausible hypothesis.Although it has been known for some time that the first growing follicles in the rat appear after 3 days of age (Beaumont and Mandl, 1962), the subsequ ent evolution and establishment of the follicular population during the prepubertal period is poorly understood. Lane (1935) studied the follicular population between 15 and 66 days of age but divided the whole follicular population into only two broad categories, primary and vesicular follicles. Other workers have studied folliculogenesis in the same period but have only considered the antral follicles (Umezu, 1970 ;Meijs-Roelofs et al., 1973).The present study was undertaken to determine the evolution of the population of growing follicles during the immature period.Furthermore since several authors have now claimed that the early stages of follicle growth are gonadotrophin dependent (Ryle, 1972 ; de Reviers and Maul6on,

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supporting

confidence: 75%

Evolution of ovarian follicular population and serum gonadotrophins in the prepubertal period of two strains of rats

Reviers¹,

Mauléon²

1979

Ann. Biol. anim. Bioch. Biophys.

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“…One plausible hypothesis is that a selective increase in plasma FSH level could result in a maturing effect of gonadotropins whereby the flattened granulosa cells are transformed into cuboidal granulosa cells, as previously shown in both rodents [35,36] and primates [37]. The progressive increase in FSH could also explain the observation that in women the proportion of EGF increases when the pool of NGF decreases [3].…”

Section: Discussionmentioning

confidence: 78%

Age-Related Changes of the Population of Human Ovarian Follicles: Increase in the Disappearance Rate of Non-Growing and Early-Growing Follicles in Aging Women

Gougeon

Écochard

Thalabard

1994

Biology of Reproduction

405

194

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The effect of aging on the number of non-growing follicles (NGF) and early-growing follicles (EGF) was studied in humans through use of a database obtained by pooling two subsets of ovarian pairs (2 x 43 pairs) collected in two distinct populations. A previously suggested model of exponential regression of NGF counts in relation to the subject's age was tested but did not adequately fit the observed data points. This lack of fit is attributable mainly to the existence of a significant relation between a woman's age and the corresponding NGF count decay rate. Consequently, various regression models were tested. Two different periods of decay rate were observed for each population of small follicles. The first corresponds to younger ages with a decay rate that is slow for both types of follicles, although faster for NGF than for EGF. The second period corresponds to older ages with an accelerated decay rate that appears similar for NGF and EGF. The changing points were found at 38.0 +/- 2.4 and 39.0 +/- 1.9 yr (mean +/- SD) for NGF and EGF, respectively. Extrapolation of the fitted model suggested the presence of approximately 402,000 healthy NGF per ovary at birth and a total exhaustion of the follicular stock at around 74 yr of age. These results support the view that depletion of the NGF pool is caused mainly by atresia in younger women but mainly by entrance of NGF into the growing pool in older women. The mechanisms triggering accelerated entrance into the growth phase of NGF are discussed in relation to the previously reported increase in FSH plasma levels that starts in the late thirties, approximately, and precedes the menopausal period by several years.

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“…Although data in the mouse remain controversial, it is generally believed that this initial event can proceed without gonadotropic support [15]. Indeed, some studies failed to observe the effects of these hormones on small, nongrowing follicles [16], but age selection might be a key factor in determining responsiveness [17]. The appreciable amount of circulating gonadotropin in the perinatal mouse suggests that the hormone is present for a developmental reason [15,18].…”

Section: Introductionmentioning

confidence: 99%

Dynamics of Ovarian Development in the FORKO Immature Mouse: Structural and Functional Implications for Ovarian Reserve

Balla

Danilovich

Yang

et al. 2003

Biology of Reproduction

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Adult Follitropin Receptor Knockout (FORKO) female mice are infertile and estrogen deficient. In order to understand the peri/postnatal developmental changes, we have now characterized the structural and molecular aberrations by comparing several markers of follicular development in 2-, 10-, and 24-day-old wild-type and FORKO females. By Day 24, FORKO mice have 40%-50% smaller uteri and vaginas. Estradiol is undetectable but testosterone and LH levels are already elevated at this age. FORKO ovaries are 45% smaller, indicating a postnatal or perinatal deficit consequent to FSH receptor ablation. This is attributable to decreased numbers of growing follicles and reduced diameter. Developmental markers, such as Müllerian inhibiting substance, GATA-4, estrogen receptor beta, and androgen receptor, were differentially expressed in granulosa cells. In the 2-day-old mutant neonates, a faster recruitment process was noted that later slowed down, impeding development of follicles. This is noteworthy in light of the controversy regarding the direct role of FSH/receptor system as a determinant of small and preantral follicle development in rodents. As the pool of nongrowing primordial follicles specifies the duration of female fertility and timing of reproductive senescence, we believe that the postnatal FORKO female mouse could help in exploring the signals that impact on early folliculogenesis. In addition, our data suggest that the FSH/receptor system is a major contributor to the formation and recruitment of the nongrowing pool of follicles as early as Postnatal Day 2 in the mouse.

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Initiation of Follicular Growth in the Infant Mouse Ovary by Exogenous Gonadotrophin

Abstract: Ovaries from female Outbred strain mice do not respond to exogenous PMSG

Cited by 31 publications

References 15 publications

Evolution of ovarian follicular population and serum gonadotrophins in the prepubertal period of two strains of rats

Evolution of ovarian follicular population and serum gonadotrophins in the prepubertal period of two strains of rats

Age-Related Changes of the Population of Human Ovarian Follicles: Increase in the Disappearance Rate of Non-Growing and Early-Growing Follicles in Aging Women

Dynamics of Ovarian Development in the FORKO Immature Mouse: Structural and Functional Implications for Ovarian Reserve

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