Initiation and inhibitory control of saccades with the progression of Parkinson's disease – Changes in three major drives converging on the superior colliculus

Terao, Yasuo; Fukuda, Hideki; Yugeta, Akihiro; Hikosaka, Okihide; Nomura, Yasuo; Segawa, Masaya; Hanajima, Ritsuko; Tsuji, Shoji; Ugawa, Yoshikazu

doi:10.1016/j.neuropsychologia.2011.03.002

Cited by 117 publications

(124 citation statements)

References 71 publications

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“…Altered oculomotor performance in PD Significant differences between PD patients and controls were demonstrated for all of the investigated eye movement parameters (Table 2), in agreement with previous studies (Helmchen et al 2012;Mosimann et al 2005;Pinkhardt et al 2012;Terao et al 2011). The only exception was peak eye velocity.…”

Section: Resultssupporting

confidence: 90%

“…Nonetheless, a dysfunctional inhibitory system was consistently proposed to be responsible for a disturbed suppression of unwanted gaze shifts both in the absence of any targets (Lemos and Eggenberger 2013) and in the presence of a distracting stimulus (Munoz and Everling 2004). This 'hyper-reflexive' behavior observed for patients with PD in the present study has been previously attributed to a disturbed triggering of the 'input gate', the superior colliculus, due to abnormal firing patterns mediated by the basal ganglia (Terao et al 2011). However, this proposed model is not satisfactory to explain the full spectrum of oculomotor dysfunction including executive eye movement dysfunctions such as interrupting saccades during smooth pursuit, fixational periods as well as a high distractability in anti-saccade performance. Fig.…”

Section: Discussionsupporting

confidence: 58%

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The association between alterations of eye movement control and cerebral intrinsic functional connectivity in Parkinson’s disease

Gorges

Müller

Lulé

et al. 2015

Brain Imaging and Behavior

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Patients with Parkinson's disease (PD) present with eye movement disturbances that accompany the cardinal motor symptoms. Previous studies have consistently found evidence that large-scale functional networks are critically involved in eye movement control. We challenged the hypothesis that altered eye movement control in patients with PD is closely related to alterations of whole-brain functional connectivity in association with the neurodegenerative process. Saccadic and pursuit eye movements by video-oculography and 'resting-state' functional MRI (3 Tesla) were recorded from 53 subjects, i.e. 31 patients with PD and 22 matched healthy controls. Video-oculographically, a broad spectrum of eye movement impairments was demonstrated in PD patients vs. controls, including interrupted smooth pursuit, hypometric saccades, and a high distractibility in anti-saccades. Significant correlations between altered oculomotor parameters and functional connectivity measures were observed, i.e. the worse the oculomotor performance was, the more the regional functional connectivity in cortical, limbic, thalamic, cerebellar, and brainstem areas was decreased. Remarkably, decreased connectivity between major nodes of the default mode network was tightly correlated with the prevalence of saccadic intrusions as a measure for distractability. In conclusion, dysfunctional eye movement control in PD seems to be primarily associated with (cortical) executive deficits, rather than being related to the ponto-cerebellar circuits or the oculomotor brainstem nuclei. Worsened eye movement performance together with the potential pathophysiological substrate of decreased intrinsic functional connectivity in predominantly oculomotor-associated cerebral functional networks may constitute a behavioral marker in PD.

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Section: Resultssupporting

confidence: 90%

Section: Discussionsupporting

confidence: 58%

The association between alterations of eye movement control and cerebral intrinsic functional connectivity in Parkinson’s disease

Gorges

Müller

Lulé

et al. 2015

Brain Imaging and Behavior

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“…A more detailed cognitive status would have been particularly important for the PD patients who presented executive deficits in oculomotor functions that were correlated with volume loss of the cerebrum, since volumetric studies demonstrated that GM atrophy in PD is modest in cognitively “normal” patients but becomes marked in the presence of cognitive deficits [35]. Oculomotor abnormalities worsen when PD patients present with cognitive difficulties [22] as investigated in detail with respect to cognitive status [19] and overall disease stage [36]. Moreover, the analysis was correlational per se so that direct conclusions about causal relationships between regional volume loss and oculomotor performance are not possible.…”

Section: Discussionmentioning

confidence: 99%

Patterns of Eye Movement Impairment Correlate with Regional Brain Atrophy in Neurodegenerative Parkinsonism

Vintonyak

Gorges²,

Müller³

et al. 2017

Neurodegener Dis

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Background: One common feature of neurodegenerative parkinsonism including Parkinson's disease (PD), multisystem atrophy (MSA), and progressive supranuclear palsy (PSP) is altered eye movement control. Characteristic regional structural atrophy patterns in MRI can be observed in PD, MSA, and PSP. Objective: To investigate the association between eye movement disturbances and regional brain atrophy in patients with PD, MSA, and PSP. Methods: High-resolution 3-dimensional T1-weighted MRI images and video-oculographic recordings (EyeLink®) were obtained from 39 PD, 32 PSP, and 18 MSA patients and 24 matched healthy control subjects. Automatic regional volumetric assessment was performed using atlas-based volumetry (ABV). Results: The prevalence of saccadic intrusions as a measure of inhibitory control was significantly increased in PD patients compared to controls (p < 0.001) and negatively correlated with whole brain volume, cerebral brain volume, and occipital lobe volume (p = 0.0057, p = 0.0049, and p = 0.0059, respectively; all p values are false discovery rate corrected). In MSA, smooth pursuit was disturbed by characteristic “catch-up” saccades (p < 0.001) and it was significantly correlated with cerebellar volume (p = 0.004) and pontine volume (p < 0.001). The hallmark of PSP was pathologically slowed vertical peak eye velocities (p < 0.001); the lower the peak eye velocity, the more marked midbrain atrophy (p = 0.007). Conclusions: Foci of regional atrophy correlated with disease-specific eye movement alterations in all investigated parkinsonian syndromes. Oculomotor impairment in PD, predominantly the result of executive dysfunction, was linked to cerebral atrophy. Impairment in the corresponding oculomotor pathways was associated with atrophy of pontocerebellar oculomotor structures in MSA and midbrain atrophy in PSP.

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“…Additionally, the structures and connections underlying oculomotor neurophysiology have been well characterized (Gaymard et al, 1998;Leigh and Zee, 1999;Munoz and Everling, 2004;Munoz et al, 2000). Eye movement tasks have provided powerful insight into neurological dysfunction in clinical disorders such as Parkinson's disease (Terao et al, 2011), attention-deficit/ hyperactivity disorder (ADHD) (Mahone et al, 2009) and schizophrenia (Reuter et al, 2011). For example, deficits in eye movement control are measurable in both children and adults with ADHD, and are consistent with frontostriatal pathophysiology (Munoz et al, 2003).…”

mentioning

confidence: 99%

Diffusion Tensor Imaging Correlates of Saccadic Reaction Time in Children with Fetal Alcohol Spectrum Disorder

Green

Lebel

Rasmussen

et al. 2013

Alcohol Clin Exp Res

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The negative correlation for prosaccade SRT and cerebellum demonstrated that individuals with slower reaction times had lower FA values relative to their faster responding counterparts, a finding that implicates cerebellar dysfunction as a significant contributor to deficits in oculomotor control. The higher FA in the corpus callosum and ILF corresponding to longer reaction times for both pro- and antisaccade was opposite to what was expected, but nonetheless implies that altered brain structure in these regions underlies deficits in oculomotor control.

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Initiation and inhibitory control of saccades with the progression of Parkinson's disease – Changes in three major drives converging on the superior colliculus

Cited by 117 publications

References 71 publications

The association between alterations of eye movement control and cerebral intrinsic functional connectivity in Parkinson’s disease

The association between alterations of eye movement control and cerebral intrinsic functional connectivity in Parkinson’s disease

Patterns of Eye Movement Impairment Correlate with Regional Brain Atrophy in Neurodegenerative Parkinsonism

Diffusion Tensor Imaging Correlates of Saccadic Reaction Time in Children with Fetal Alcohol Spectrum Disorder

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