Initial Validation of a Behavioral Phenotyping Model for Substance Use Disorder
Lori Keyser-Marcus,
Tatiana Ramey,
James M. Bjork
et al.
Abstract:Standard nosological systems, such as DSM-5 or ICD-10, are relied upon as the diagnostic basis when developing treatments for individuals with substance use disorder (SUD). Unfortunately, the vast heterogeneity of individuals within a given SUD diagnosis results in a variable treatment response and/or difficulties ascertaining the efficacy signal in clinical trials of drug development. Emerging precision medicine methods focusing on targeted treatments based on phenotypic subtypes rather than diagnosis are bei… Show more
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