Initial success in the identification and management of the coronavirus disease 2019 (COVID-19) indicates human-to-human transmission in Wuhan, China

Awadasseid, Annoor; Wu, Yanling; Tanaka, Yoshimasa; Zhang, Wen

doi:10.7150/ijbs.45018

Cited by 64 publications

(48 citation statements)

References 82 publications

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“…The obtained results certainly depend on the modelled environment, and hence, also on the concentration of various metal ions [44][45][46]. There is a review article on initial successes in the identification and management of coronavirus disease in 2019 [50]. It contains a section on the physicochemical properties of SARS-CoV-2.…”

Section: Isoelectric Point and Ph Stabilitymentioning

confidence: 99%

Physicochemical properties of SARS‐CoV‐2 for drug targeting, virus inactivation and attenuation, vaccine formulation and quality control

et al. 2020

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The material properties of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its proteins are discussed. We review the viral structure, size, rigidity, lipophilicity, isoelectric point, buoyant density and centrifugation conditions, stability against pH, temperature, UV light, gamma radiation, and susceptibility to various chemical agents including solvents and detergents. Possible inactivation, downstream, and formulation conditions are given including suitable buffers and some first ideas for quality-control methods. This information supports vaccine development and discussion with competent authorities during vaccine approval and is certainly related to drug-targeting strategies and hygienics. Several instructive tables are given, including the pI and grand average of hydropathicity (GRAVY) of SARS-CoV-1 and-2 proteins in comparison. SARS-CoV-1 and SARS-CoV-2 are similar in many regards, so information can often be derived. Both are unusually stable, but sensitive at their lipophilic membranes. However, since seemingly small differences can have strong effects, for example, on immunologically relevant epitope settings, unevaluated knowledge transfer from SARS-CoV-1 to SARS-CoV-2 cannot be advised. Published knowledge regarding downstream processes, formulations and quality assuring methods is, as yet, limited. However, standard approaches employed for other viruses and vaccines seem to be feasible including virus inactivation, centrifugation conditions, and the use of adjuvants.

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Section: Isoelectric Point and Ph Stabilitymentioning

confidence: 99%

Physicochemical properties of SARS‐CoV‐2 for drug targeting, virus inactivation and attenuation, vaccine formulation and quality control

et al. 2020

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“…7. Also teaching the patients and their families regarding proper hand-washing technique, on how wear and dispose a surgical mask, how to cough and also on measures to be taken when quarantined at home (Sifuentes-Rodríguez and Palacios-Reyes, Awadasseid et al, 2020).…”

Section: Patient Managementmentioning

confidence: 99%

Stepping up detection, response, preparedness and readiness measures for “COVID-19”- A Pandemic

Balsara

Shukla

2020

ijrps

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In a very short period of time, “COVID-19” has seized the consciousness globally by making remarkable changes in our day to day living and has superintended as a public health emergency globally. It has high radar of transmission, affecting an individual at work to frontline workers. The measures and planning for a response plays a key role from drawing up an emergency committee and this follows an equation which broadly deals with epidemiological to clinical history of the patient, management steps from isolation, screening, diagnostic assays for identification and treatment. The application of an organized plan with secure structure aids in better performance, increases efficacy of management and saves time. Also saves time for a health care worker to g through routine levels of channels of administration if already a familiar way of operation is known for such situations. Thus, planning and developing a ‘blueprint of approach’ towards management of patient while facing such situation is a must. This review provides an insight to the measures for detection, response and preparedness of the hospital and health care workers should largely be inclusive of; also highlights the measures to be taken at every step after coming in contact with a positive case of “COVID-19”.

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“…Schwere COVID-19 Komplikationen sind respiratorisches Versagen, Arrhythmie, akute kardiale Dekompensation und thrombembolische Ereignisse. Schwangere, die an einer COVID-19 Pneumonie erkranken, zeigen ein ähnliches Risiko intensivmedizinischer Versorgungsnotwendigkeit wie gleichaltrige Nichtschwangere [ 5 , 6 , 15 ]. Kritische Verläufe mit invasiver Beatmung und teilweise Notwendigkeit einer extrakorporalen Membranoxygenierung kommen vor [ 16 ].…”

Section: Schwangerschaftunclassified

Schwangerschaft, Geburt und Wochenbett mit SARS-CoV-2 und COVID-19

et al. 2020

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Initial success in the identification and management of the coronavirus disease 2019 (COVID-19) indicates human-to-human transmission in Wuhan, China

Abstract: Coronavirus (CoV) has been one of the major pandemic threats to human health in the last two decades.

Cited by 64 publications

References 82 publications

Physicochemical properties of SARS‐CoV‐2 for drug targeting, virus inactivation and attenuation, vaccine formulation and quality control

Physicochemical properties of SARS‐CoV‐2 for drug targeting, virus inactivation and attenuation, vaccine formulation and quality control

Stepping up detection, response, preparedness and readiness measures for “COVID-19”- A Pandemic

Schwangerschaft, Geburt und Wochenbett mit SARS-CoV-2 und COVID-19

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