Initial Steps in the Unifying Theory of the Pathogenesis of Artery Aneurysms

Jacob, Theresa; Ascher, Enrico; Hingorani, Anil; Gunduz, Yilmaz; Kallakuri, Shreedhar

doi:10.1006/jsre.2001.6193

Cited by 44 publications

(25 citation statements)

References 25 publications

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“…Several in vitro studies in human cells have also shown that P53/P21-induced senescence results in increased expression of IL6, IL8, and MCP1 (1,13,33,40,46). Importantly, there is evidence that arterial P53/P21-induced senescence may play a role in carotid artery disease (38), chronic obstructive pulmonary disease (40), as well as popliteal artery aneurysm (28). Marchand et al (37) reported greater P21 mRNA expression in arteries from older coronary artery bypass graft patients compared with middle-aged patients, but it was unknown whether age-related P53/P21-induced senescence occurs in arteries from subjects that are more generalizable.…”

Section: Discussionmentioning

confidence: 99%

Age-related telomere uncapping is associated with cellular senescence and inflammation independent of telomere shortening in human arteries

Morgan

Ives

Lesniewski

et al. 2013

American Journal of Physiology-Heart and Circulatory Physiology

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Section: Discussionmentioning

confidence: 99%

Age-related telomere uncapping is associated with cellular senescence and inflammation independent of telomere shortening in human arteries

Morgan

Ives

Lesniewski

et al. 2013

American Journal of Physiology-Heart and Circulatory Physiology

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“…Para Ticket et al (7) , y Hencke et al (8) , la frecuencia de AAP en la población general es del 0.1% ascendiendo al 1% en hombres de entre 65 y 80 años. Afectan principalmente a pacientes de sexo masculino entre la sexta y la octava décadas de vida, a una edad promedio de 65 años; presentan una alta tasa de bilateralidad y frecuentemente asociados a aneurismas en otras arterias (1)(2)(3)(4)(5)(6) . Los AAP son los más comunes entre los aneurismas periféricos (1; 6) .…”

Section: Discussionunclassified

“…Se caracteriza por afecta principalmente hombres a una edad promedio de 65 años, siendo sintomático en alrededor del 60 por ciento de los casos, cuyas manifestaciones son principalmente de origen isquémico, acabando en amputación del miembro inferior en una frecuencia que oscila según la literatura entre un 7 y un 20 por ciento (1)(2)(3)(4)(5)(6) . Se define como aneurisma de la arteria poplítea cuando existe dilatación transversal de la arteria poplítea de más de 2 cm, o mayor a 150 % del diámetro arterial normal (1) .…”

Section: Introductionunclassified

Aneurismas de la Arteria Poplitea: Revisión bibliográfica y presentación de un caso

Cecenarro

Allende

Molinelli

et al. 2018

Rev Fac Cien Med Univ Nac Cordoba

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. Resumen:Introducción: El aneurisma de la arteria poplítea (AAP) es la dilatación localizada e irreversible de las paredes de la Arteria Poplítea. Es patología poco frecuente, constituye la segunda ubicación más frecuente de aneurismas verdaderos luego de los aórticos, y la primera ubicación dentro de los aneurismas periféricos. Se caracteriza por afectar a principalmente a hombres a una edad promedio de 65 años, cuyas manifestaciones son principalmente de origen isquémico, acabando en amputación del miembro inferior en una frecuencia que oscila según los casos entre un 7 y un 20 por ciento. Nuestro objetivo es realizar la presentación de un caso de AAP con isquemia arterial subaguda, junto con una actualización bibliográfica del tema. Presentación de caso: Se presenta el caso de un paciente de 63 años de edad quien consultó por dolor de miembro inferior 96 horas de evolución, con ausencia de pulsos. Se realizó el diagnóstico de isquemia subaguda evolucionada, no resvascularizable en el contexto de un paciente clínicamente inestable. Se decide amputación de urgencia. En la disección se objetiva la presencia de un AAP. Discusión: Los AAP tienen una incidencia de entre el 0,1 al 1%, presentan clínica variable. La arteriografía es gold standard para su diagnóstico. El tratamiento de elección es quirúrgico, presentándose nuevas opciones terapéuticas. Las variaciones anatómicas de las ramas de la AP son una variable a considerar. Los aneurismas asociados con mayor frecuencia son los poplíteos contralaterales (57,1%). Conclusiones: Concluimos que nuestra conducta fue adecuada considerando el estado del paciente.Palabras clave: aneurisma de la arteria poplítea; reporte de caso; revisión bibliográfica. Abstract:Introduction: The popliteal artery aneurysm (AAP) is localized and irreversible walls of the popliteal artery dilation. It is rare pathology is the second most common location of true aneurysms after aortic, and the first location within the peripheral aneurysms. It is characterized by affecting mainly men at an average age of 65, whose manifestations are mainly ischemic, finishing lower limb amputation in a frequency ranging as appropriate between 7 and 20 percent. Our goal is to make the presentation of a case of AAP with subacute arterial ischemia, along with a literature review of the topic. Case presentation: the case of a 63 year old who consulted for lower limb pain 96 hours of evolution, with absence of pulses is presented a diagnosis of advanced subacute ischemia was performed resvascularizable not in the context of a clinically unstable patient. emergency amputation is decided. In dissecting the presence of PSA objective. Discussion: The AAP have an incidence of 0.1 to 1%, have variable clinical. Arteriography is the gold standard for diagnosis. The treatment of choice is surgical, presenting new therapeutic options. The anatomical variations of the branches of the PA are variable to consider. Aneurysms are most commonly associated with contralateral popliteal (57.1%). Conclusions: We conclude that our...

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“…We noted higher elastin degradation and enhanced apoptosis in Thbs1 −/− ApoE −/− mice compared with the control ApoE −/− mice. VSMC loss due to apoptosis is believed to be a crucial step in AAA progression [70] and TSP-1 is known to be involved in the clearance of apoptotic neutrophils and eosinophils by macrophages [71,72]. The increased apoptotic cell numbers observed in the SRA of Thbs1 −/− ApoE −/− mice could be due to the defective clearance of apoptotic cells rather than an increased apoptosis per se.…”

Section: Lower In Thbs1mentioning

confidence: 99%

High serum thrombospondin-1 concentration is associated with slower abdominal aortic aneurysm growth and deficiency of thrombospondin-1 promotes angiotensin II induced aortic aneurysm in mice

et al. 2017

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Abdominal aortic aneurysm (AAA) is a common age-related vascular disease characterized by progressive weakening and dilatation of the aortic wall. Thrombospondin-1 (TSP-1; gene Thbs1) is a member of the matricellular protein family important in the control of extracellular matrix (ECM) remodelling. In the present study, the association of serum TSP-1 concentration with AAA progression was assessed in 276 men that underwent repeated ultrasound for a median 5.5 years. AAA growth was negatively correlated with serum TSP-1 concentration (Spearman's rho − 0.129, P=0.033). Men with TSP-1 in the highest quartile had a reduced likelihood of AAA growth greater than median during follow-up (OR: 0.40; 95% confidence interval (CI): 0.19-0.84, P=0.016, adjusted for other risk factors). Immunohistochemical staining for TSP-1 was reduced in AAA body tissues compared with the relatively normal AAA neck. To further assess the role of TSP-1 in AAA initiation and progression, combined TSP-1 and apolipoprotein deficient (Thbs1 −/− ApoE −/− , n=20) and control mice (ApoE −/− , n=20) were infused subcutaneously with angiotensin II (AngII) for 28 days. Following AngII infusion, Thbs1 −/− ApoE −/− mice had larger AAAs by ultrasound (P=0.024) and ex vivo morphometry measurement (P=0.006). The Thbs1 −/− ApoE −/− mice also showed increased elastin filament degradation along with elevated systemic levels and aortic expression of matrix metalloproteinase (MMP)-9. Suprarenal aortic segments and vascular smooth muscle cells (VSMCs) isolated from Thbs1 −/− ApoE −/− mice showed reduced collagen 3A1 gene expression. Furthermore, Thbs1 −/− ApoE −/− mice had reduced aortic expression of low-density lipoprotein (LDL) receptor-related protein 1. Collectively, findings from the present study suggest that TSP-1 deficiency promotes maladaptive remodelling of the ECM leading to accelerated AAA progression.

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Initial Steps in the Unifying Theory of the Pathogenesis of Artery Aneurysms

Cited by 44 publications

References 25 publications

Age-related telomere uncapping is associated with cellular senescence and inflammation independent of telomere shortening in human arteries

Age-related telomere uncapping is associated with cellular senescence and inflammation independent of telomere shortening in human arteries

Aneurismas de la Arteria Poplitea: Revisión bibliográfica y presentación de un caso

High serum thrombospondin-1 concentration is associated with slower abdominal aortic aneurysm growth and deficiency of thrombospondin-1 promotes angiotensin II induced aortic aneurysm in mice

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