Initial Staging of Lymphoma With Positron Emission Tomography and Computed Tomography

Hicks, Rodney J.; Manus, Michael P. Mac; Seymour, John F.

doi:10.1053/j.semnuclmed.2005.02.003

Cited by 78 publications

(37 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, integrated PET and CT with FDG (FDG-PET/CT) has appeared as a new imaging modality, providing anatomic and metabolic information. FDG-PET/CT allows more accurate spatial localization of abnormal 18 F-FDG uptake than PET alone, and it has become the most preferable initial staging tool for patients with NHL [19]. As for 67 Ga scintigraphy, SPECT/CT scan is also B A Fig.…”

Section: Discussionmentioning

confidence: 99%

A 18F-FDG-positive, 67Ga-negative, and transferrin receptor expression-negative patient with diffuse large B-cell lymphoma

et al. 2007

View full text Add to dashboard Cite

We recently experienced a case with uveitis suffering from fever of unknown origin suspected of being caused by sarcoidosis. Chest computed tomography showed right supraclavicular, bilateral mediastinal, and right hilar lymphadenopathy, and intensive abnormal uptake of 2-[18F]fluoro-2-deoxy-D-glucose (18F-FDG) was observed on positron emission tomography with 18F-FDG (FDG-PET). On the other hand, 67Ga scintigraphy showed almost no abnormal findings. Histopathological examination revealed the lesion to be a diffuse large B-cell lymphoma (DLBCL), namely, an aggressive non-Hodgkin lymphoma from a right supraclavicular lymph node biopsy specimen. Additional immunohistochemical analysis showed the negative expression of transferrin receptor (TfR) on the formalin-fixed paraffin-embedded specimen. Although DLBCL is generally considered to be a 67Ga-avid tumor, it does not always have a large number of TfRs and that leads to a discrepancy between the 67Ga scintigraphy and FDG-PET findings. FDG-PET should be more appropriate for the initial staging of DLBCL than 67Ga scintigraphy, whereas 67Ga scintigraphy might be able to provide additional information including prognostic factors and to support strategies that target TfR for cancer therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

A 18F-FDG-positive, 67Ga-negative, and transferrin receptor expression-negative patient with diffuse large B-cell lymphoma

et al. 2007

View full text Add to dashboard Cite

show abstract

“…36,37 The development of simultaneous PET-CT scanning provides combined images of morphology and function in the same study, providing useful information for the optimal management in these patients. 38 Our approach for the imaging in patients with OALD is to request an axial and coronal head and orbit CT-scan with contrast prior to the biopsy of any case in which a lymphoproliferative disease is suspected, in an attempt to define the location, extension, tissue invasion, bone changes and intrinsic features of the lesion (homogeneity, moulding, enhancement, etc). MRI may help in a number of situations, such as cases, which present a convex contour in the superior orbit on CT which might be due to lymphoma or due to a subperositeral haematoma.…”

Section: Discussionmentioning

confidence: 99%

Imaging features of ocular adnexal lymphoproliferative disease

Sullivan

Valenzuela²

2006

Eye

View full text Add to dashboard Cite

Purpose To evaluate the imaging characteristics of a cohort of patients with ocular adnexal lymphoproliferative disease (OALD). Methods A noncomparative retrospective review between 1992 and 1995 and prospective study from 1995 to 2005 of the clinical, imaging and treatment of 105 patients presenting to tertiary orbital referral centre presenting with OALD. Results One hundred and five patients (mean age 61 years, range 11-90 years) with equal gender distribution were included. Fifty-three were primary and 52 were secondary. Computed tomography (CT) usually showed a well-circumscribed lesion of greater than brain density, moulding to adjacent tissues with moderate enhancement. Aggressive histology was associated with bone destruction, while moulding was associated with indolent histology (Po0.005). MRI in OALD showed intermediate signal intensity on T1-and T2-weighted images and moderate enhancement with gadolinium. Gallium scanning sensitivity to detect ocular adnexal disease was 25 and 57% for systemic involvement. Positron emission tomography (PET) upstaged (71%) of patients with systemic lymphoproliferative involvement, having a higher sensitivity than CT in detecting distant disease (86 vs 72%). Conclusions CT and/or MRI are essential in the evaluation of OALD and can be used to establish that an orbital lesion may be lymphoprolifetaive in nature. Further, these imaging modalities may predict the behaviour of the lymphoma in certain cases. Gallium scanning provides no additional information to CT and does not influence patient treatment. PET represents an important addition to the assessment of OALD with real impact on patient management.

show abstract

“…Específicamente, en casos con extensión extraganglionar, el contar con PET/TC ayuda a tener mejor rendimiento respecto a la tecnología PET dedicado en forma aislada, por ejemplo, en compromiso muscular 30 .…”

Section: Etapificación Y Reetapificaciónunclassified

Utilidad de la deoxiglucosa marcada con flúor-18 (FDG) en el manejo de los linfomas

Massardo

et al. 2006

Rev. méd. Chile

View full text Add to dashboard Cite

Positron emission tomography (PET) with fluorine-18 labeled deoxyglucose (FDG) is useful in the management of lymphomas. In this review, some general concepts of this metabolic test are defined. It has an excellent diagnostic yield in (Rev Méd Chile 2006; 134: 910-9E l linfoma es una patología maligna del sistema linfático, potencialmente curable en una importante proporción de pacientes, con buena respuesta a quimioterapia, radioterapia o ambas.La incidencia de linfoma no Hodgkin (LNH) está en aumento en el mundo occidental y se ha observado asociación con diversas patologías virales, en especial con infección por virus de inmunodeficiencia humana. El linfoma de Hodgkin (LH) también ha aumentado su incidencia, asociándose a otras infecciones virales. Paralelamente, la terapia y sobrevida han mejorado, lo cual conduce a mayor número de pacientes que pueden presentar efectos indeseables tardíos de la terapia, más relevantes en población de menor

show abstract

Initial Staging of Lymphoma With Positron Emission Tomography and Computed Tomography

Cited by 78 publications

References 38 publications

A 18F-FDG-positive, 67Ga-negative, and transferrin receptor expression-negative patient with diffuse large B-cell lymphoma

A 18F-FDG-positive, 67Ga-negative, and transferrin receptor expression-negative patient with diffuse large B-cell lymphoma

Imaging features of ocular adnexal lymphoproliferative disease

Utilidad de la deoxiglucosa marcada con flúor-18 (FDG) en el manejo de los linfomas

Contact Info

Product

Resources

About