Initial resuscitation with plasma and other blood components reduced bleeding compared to hetastarch in anesthetized swine with uncontrolled splenic hemorrhage

Abstract

These data suggest that blood products as initial resuscitation fluids reduced PRBL from a noncompressible injury compared to Hextend, preserved coagulation, and provided sustained volume expansion. There were no differences on PRBL among RBCs-to-FFP, FWB, or FFP in this nonmassive transfusion model.

Double-blinded, placebo-controlled study of early tranexamic acid treatment in swine uncontrolled hemorrhage model

“…We have a noncompressible hemorrhage, prehospital swine model with which we successfully demonstrated that fresh frozen plasma (FFP) administration along with hypotensive resuscitation significantly reduced postresuscitation blood loss and increased 5-hour survival compared with Hextend (HEX). 12 The purpose of this study was to determine if the administration of TXA before hypotensive resuscitation with HEX or FFP reduced the rate of postresuscitation blood loss in our model of noncompressible hemorrhage. Since the Tactical Combat Casualty Care (TCCC) committee recommends that two boluses (infused over 10 minutes) be administered in the field in tactical situations rather than start an 8-hour infusion for the second dose as is recommended for the Damage Control Resuscitation Clinical Practice Guideline, 13 we tested their recommended strategy for this study (Frank Butler, chair of TCCC committee, personal communication regarding TXA use in Tactical Field Care, October 2014).…”

Treatment Option for High Grade Spleen Injury and Predictive Factors for Non-operative Management

“…Watson et al [18] reviewed 3,085 adults, and found that failure of NOM AIS ≥4 was up to 54.6%. Other studies on the relationship between failure of the NOM and the ISS note higher failure rates of NOM if the ISS is greater than 25 [19].…”

Molecular mechanisms of trauma-induced acute kidney injury: Inflammatory and metabolic insights from animal models

“…Although the majority of studies in animal models of HS have focused on the effects of various fluid resuscitation formulations on hemodynamics and survival [131], a few have included renal function. In a study of asymptomatic pneumonia after HS, pigs resuscitated with LR had significantly lower urine output compared to healthy A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT 26 pigs, suggesting some degree of renal failure [132].…”