Initial results of the treatment of diffuse sclerosing osteomyelitis of the mandible with bisphosphonates

Kuijpers, Sophie C.C.; Jong, Edo de; Hamdy, Neveen A. T.; Merkesteyn, J.P.R. van

doi:10.1016/j.jcms.2010.03.014

Cited by 56 publications

(42 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Three months after starting pamidronate all patients showed relief of pain and partial or complete resolution of vertebral hyperintensity on MRI after 13 months [17]. Finally, there is evidence in the literature of pamidronate efficacy for the treatment of diffuse sclerosing osteomyelitis of the mandible [79].…”

Section: Treatmentmentioning

confidence: 82%

Chronic Recurrent Multifocal Osteomyelitis

Costa-Reis

Sullivan

2013

J Clin Immunol

View full text Add to dashboard Cite

Chronic recurrent multifocal osteomyelitis is a rare auto-inflammatory condition that primarily affects children and adolescents. It presents with recurrent episodes of pain related to the presence of foci of sterile bone inflammation. The long bones of the lower extremities are more frequently affected and the spine can also be involved. Imaging studies, including whole-body magnetic resonance, are important for diagnosis and detection of asymptomatic lesions. Bone biopsies may be necessary to exclude other diseases, including malignancy and infections. Non-steroidal anti-inflammatory drugs cause relief of symptoms in the majority of cases. Bisphosphonates and TNF-α blockers are alternatives for patients who do not respond or who have spinal involvement.

show abstract

Section: Treatmentmentioning

confidence: 82%

Chronic Recurrent Multifocal Osteomyelitis

Costa-Reis

Sullivan

2013

J Clin Immunol

View full text Add to dashboard Cite

show abstract

“…Corticosteroids have been reported to be successful, but side-effects limit the usefulness in long-term treatment. Perhaps the strongest data for the next step in treatment are available for the intravenous bisphophonate pamidronate [52][53][54][55][56][57][58][59][60][61][62][63][64] (see Table 1 pamidronate with resolution of bone inflammation on MRI after 6 months of treatment. Four patients had MRI confirmed recurrence of CRMO, which responded to one pamidronate retreatment.…”

Section: Treatmentmentioning

confidence: 99%

Clinical care of children with sterile bone inflammation

Twilt¹,

Laxer

2011

Current Opinion in Rheumatology

View full text Add to dashboard Cite

show abstract

“…Effectiveness of an intravenous bisphosphonate (clodronate) for DSOM was first reported by Montonen et al [12]. Many cases of intravenous pamidronate used for DSOM have been reported [13][14][15][16]. However, use of intravenous bisphosphonates for the treatment of bony complications is associated with undesirable adverse effects such as renal dysfunction, injection site reaction, flu-like syndrome [17,18], and osteonecrosis of the jaw [19].…”

Section: Discussionmentioning

confidence: 99%