Initial Research of Inflammation with Its Effect on Biomechanical Strength of Involved Aorta in Type A Aortic Dissection and Ascending Thoracic Aortic Aneurysm

Bai, Zhixuan; Gu, Jun; Shi, Yingkang; Meng, Wei

doi:10.14744/anatoljcardiol.2018.49344

Cited by 9 publications

(8 citation statements)

References 19 publications

(21 reference statements)

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“…Nevertheless, it is commonly accepted that a medial degeneration, either from an inherited connective tissue disorder or from an acquired condition compromising the aortic integrity, is fundamental to allow aortic dissection [64], [136], [137]. This degeneration manifests itself by inflammation and extracellular matrix degradation [12], [138], [139]. Hence, mechanical phenomena inducing intimal tears should be investigated in conjunction with biological events that may favor the occurrence of these intimal injuries.…”

Section: Discussionmentioning

confidence: 99%

Review of Current Advances in the Mechanical Description and Quantification of Aortic Dissection Mechanisms

Brunet

Pierrat

Badel

2021

IEEE Rev. Biomed. Eng.

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Aortic dissection is a life-threatening event associated with a very poor outcome. A number of complex phenomena are involved in the initiation and propagation of the disease. Advances in the comprehension of the mechanisms leading to dissection have been made these last decades thanks to improvements in imaging and experimental techniques. However, the micro-mechanics involved in triggering such rupture events remains poorly described and understood. It constitutes the primary focus of the present review. Towards the goal of detailing the dissection phenomenon, different experimental and modeling methods were used to investigate aortic dissection, and to understand the underlying phenomena involved. In the last ten years, research has tended to focus on the influence of microstructure on initiation and propagation of the dissection, leading to a number of multiscale models being developed. This review brings together all this material in an attempt to identify main advances and remaining questions.

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Section: Discussionmentioning

confidence: 99%

Review of Current Advances in the Mechanical Description and Quantification of Aortic Dissection Mechanisms

Brunet

Pierrat

Badel

2021

IEEE Rev. Biomed. Eng.

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“…The second stage of inflammatory reactions is the rapid development to acute inflammation after aortic injuries [5,6]. And it can subsequently develop to systemic inflammatory reactions syndrome (SIRS) due to uncontrolled inflammatory cascade [17]. Aortic samples from the patients with aortic dissection revealed a large amount of macrophages infiltration [18].…”

Section: Discussionmentioning

confidence: 99%

Predictors for the development of preoperative oxygenation impairment in acute aortic dissection in hypertensive patients

Zhao

Bie

2020

BMC Cardiovasc Disord

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Background: Acute aortic dissection (AAD) is an acute life-threatening cardiovascular disease, which is frequently complicated with oxygenation impairment (OI). We aim to investigate predictors of the development of OI in the patients with AAD. Methods: We retrospectively collected clinical data of AAD in hypertensive patients from July 2012 to March 2020. The patients included in this study were divided into OI (+) group (oxygenation index≤200) and OI (−) group (oxygenation index> 200). Both groups were compared according to demographic and clinical characteristics, and laboratory findings. Characteristics of hypertension in the patients with AAD were described. Predictors for the development of OI were assessed. And cutoff values were determined by receiver operating characteristics (ROC) curve. Results: A total of 208 patients were included in this study and the incidence of OI was 32.2%. In OI (+) group, patients had significantly higher peak body temperature (37.85 ± 0.60 vs 37.64 ± 0.44°C, P = .005), higher levels of CRP (42.70 ± 28.27 vs 13.90 ± 18.70 mg/L, P = .000) and procalcitonin (1.07 ± 3.92 vs 0.31 ± 0.77μg/L, P = .027), and lower levels of albumin (34.21 ± 5.65 vs 37.73 ± 4.70 g/L, P = .000). Spearman's rank correlation test showed that the minimum oxygenation index was positively correlated with albumin, and was negatively correlated with the peak body temperature, serum CRP, procalcitonin, BNP and troponin. The stepwise multiple linear regression analysis showed that the peak body temperature, serum CRP and albumin were independently associated with development of OI. An optimal cutoff value for CRP for predicting OI was ≥9.20 mg/L, with a sensitivity of 91.0% and a specificity of 61.0%. Conclusions: The peak body temperature, serum CRP and albumin were independent predictors of OI development in the patients with AAD. The serum CRP on admission≥9.20 mg/L might be a valuable and reliable indicator in predicting the development of OI.

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“…The second stage of in ammatory reactions is the rapid development to acute in ammation after aortic injuries [5,6]. And it can subsequently develop to systemic in ammatory reactions syndrome (SIRS) due to uncontrolled in ammatory cascade [17]. Aortic samples from the patients with aortic dissection revealed a large amount of macrophages in ltration [18].…”

Section: Discussionmentioning

confidence: 99%

Predictors for the development of preoperative oxygenation impairment in acute aortic dissection in hypertensive patients

Zhao¹,

Bie

2020

Preprint

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Background Acute aortic dissection (AAD) is an acute life-threatening cardiovascular disease, which is frequently complicated with oxygenation impairment (OI). We aim to investigate predictors of the development of OI in the patients with AAD.Methods We retrospectively collected clinical data of AAD in hypertensive patients from July 2012 to March 2020. The patients included in this study were divided into OI (+) group (oxygenation index≤200) and OI (-) group (oxygenation index>200). Both groups were compared according to demographic and clinical characteristics, and laboratory findings. Characteristics of hypertension in the patients with AAD were described. Predictors for the development of OI were assessed. And cutoff values were determined by receiver operating characteristics (ROC) curve.Results A total of 208 patients were included in this study and the incidence of OI was 32.2%. In OI (+) group, patients had significantly higher peak body temperature (37.85±0.60 vs 37.64±0.44℃, P= .005), higher levels of CRP (42.70±28.27 vs 13.90±18.70mg/L, P= .000) and procalcitonin (1.07±3.92 vs 0.31±0.77ug/L, P= .027), and lower levels of albumin (34.21±5.65 vs 37.73±4.70g/L, P= .000). Spearman’s rank correlation test showed that the minimum oxygenation index was positively correlated with albumin, and was negatively correlated with the peak body temperature, serum CRP, procalcitonin, BNP and troponin. The stepwise multiple linear regression analysis showed that the peak body temperature, serum CRP and albumin were independently associated with development of OI. An optimal cutoff value for CRP for predicting OI was ≥9.20 mg/L, with a sensitivity of 91.0% and a specificity of 61.0%.Conclusions The peak body temperature, serum CRP and albumin were independent predictors of OI development in the patients with AAD. The serum CRP on admission≥9.20 mg/L might be a valuable and reliable indicator in predicting the development of OI.

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Initial Research of Inflammation with Its Effect on Biomechanical Strength of Involved Aorta in Type A Aortic Dissection and Ascending Thoracic Aortic Aneurysm

Cited by 9 publications

References 19 publications

Review of Current Advances in the Mechanical Description and Quantification of Aortic Dissection Mechanisms

Review of Current Advances in the Mechanical Description and Quantification of Aortic Dissection Mechanisms

Predictors for the development of preoperative oxygenation impairment in acute aortic dissection in hypertensive patients

Predictors for the development of preoperative oxygenation impairment in acute aortic dissection in hypertensive patients

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