Initial Memory Deficit Profiles in Patients with a Cerebrospinal Fluid Alzheimer's Disease Signature

Xie, Jing; Gabelle, Audrey; Dorey, Aline; Garnier‐Crussard, Antoine; Perret‐Liaudet, Armand; Delphin-Combe, Floriane; Bathsavanis, Anthony; Dauphinot, Virginie; Lehmann, Sylvain; Mercier, Bernadette; Desestret, Virginie; Roullet-Solignac, Isabelle; Vighetto, Alain; Krolak‐Salmon, Pierre

doi:10.3233/jad-131916

Cited by 12 publications

(13 citation statements)

References 39 publications

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“…In this context, tests assessing episodiclike memory, thought to assess the function of the hippocampus complex, have been increasingly used as an early marker of AD and amnesia was eventually considered as the core clinical feature of typical AD. This overlap between amnesia, AD and hippocampal dysfunctions led some authors to hypothesize the existence of an "amnestic syndrome of hippocampal type" (Dubois et al, 2004;Sarazin et al, 2007;Xie et al, 2014) or in other words, a cognitive syndrome characterized by memory storage difficulties due to hippocampal atrophy, that would be specific to AD. Cued memory paradigms and the FCSRT in particular, were then subsequently used to track the conversion from MCI to AD (Sarazin et al, 2007), as well as for the positive (Dubois et al, 2004(Dubois et al, , 2014Xie et al, 2014) and differential diagnosis of AD (Pasquier et al, 2001;Teichmann et al, 2017;Lemos et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Does amnesia specifically predict Alzheimer’s pathology? A neuropathological study

Bertoux¹,

Cassagnaud

Lebouvier

et al. 2020

Neurobiology of Aging

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Amnesia is a key component of Alzheimer's disease (AD) and the most important feature of its clinical diagnosis but its specificity has recently been challenged. This study investigated the ability of amnesia to predict AD in a clinicopathological dementia series. Ninety-one patients to which free and cued verbal memory assessment was administered during early cognitive decline, were followed until autopsy. Patients' histological diagnoses were classified as pure-AD, mixed-AD and non-AD pathologies. Data-driven automated classification procedures explored the correspondence between memory performance and pathological diagnoses. Classifications revealed three clusters of performance reflecting different levels of amnesia. Little correspondence between these clusters and the presence of AD pathology was retrieved. A third of patients with pure/mixed AD pathology were nonamnesic at presentation and ≈45% of patients without AD pathology were amnesic. Datadriven prediction of AD pathology based on memory also had a poor accuracy. Free and cued memory assessments are fair tools to diagnose an amnesic syndrome but lack of accuracy to predict AD pathology.

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Section: Discussionmentioning

confidence: 99%

Does amnesia specifically predict Alzheimer’s pathology? A neuropathological study

Bertoux¹,

Cassagnaud

Lebouvier

et al. 2020

Neurobiology of Aging

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“…pFCSRT 1 IR performance detects amnestic MCI and dementia, predicts future dementia and AD, and distinguishes AD dementias from non-AD dementias [30][31][32][33][34][35][36]. Accumulating data demonstrating its association with the CSF AD signature [37,38], structural and functional imaging [39][40][41], and autopsy-markers of AD [42] has prompted pFCSRT 1 IR's use in ongoing clinical trials [35,43].…”

Section: Discussionmentioning

confidence: 99%

Identifying memory impairment and early dementia in primary care

Grober

Wakefield

Ehrlich

et al. 2017

Alz & Dem Diag Ass & Dis Mo

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IntroductionThis study examined the operating characteristics of two-stage case finding to identify memory impairment and very mild dementia.MethodsPrimary care patients underwent two-stage testing and a subsequent diagnostic assessment to assess outcomes. Patients who screen positive for subjective cognitive decline on the Informant Questionnaire on Cognitive Decline in the Elderly undergo memory testing with the Free and Cued Selective Reminding Test with Immediate Recall. Outcomes were determined without access to these data. A split-half design with discovery and confirmatory samples was used.ResultsOne hundred seventeen of 563 (21%) patients had dementia and 68 (12%) had memory impairment but not dementia. Operating characteristics were similar in the discovery and confirmatory samples. In the pooled sample, combined, patients with memory impairment or dementia were identified with good sensitivity (72%) and high specificity (90%). Differences in ethnicity, educational level, or age (≤75, >75) did not affect classification accuracy.DiscussionTwo-stage screening facilitates the efficient identification of older adults with memory impairment or dementia.

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“…When persons with SMC were classified into subgroups according to their CSF Aβ levels, the Aβ positive group performed lower on several FSCRT scores (i.e., learning, total learning, total recall) than the Aβ negative group. Moreover, both FR and TR were significantly impaired in 88% of prodromal and mild AD patients presenting with memory complaints and who were Aβ+ (Xie et al, 2014). Furthermore, Wagner et al (2012) demonstrated that TR was superior to FR for distinguishing patients with a low CSF Aβ/tau ratio (compatible with AD) from persons with a normal ratio.…”

Section: Introductionmentioning

confidence: 96%

Prediction of Free and Cued Selective Reminding Test Performance Using Volumetric and Amyloid-Based Biomarkers of Alzheimer’s Disease

Quenon

Dricot

Woodard

et al. 2016

J Int Neuropsychol Soc

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Initial Memory Deficit Profiles in Patients with a Cerebrospinal Fluid Alzheimer's Disease Signature

Abstract: In a population initially presenting with memory complaints and depicting a CSF AD signature, a high proportion of medial temporal amnesia is disclosed as expected, but also a proportion of dysexecutive amnesia and normal FCSRT.

Cited by 12 publications

References 39 publications

Does amnesia specifically predict Alzheimer’s pathology? A neuropathological study

Does amnesia specifically predict Alzheimer’s pathology? A neuropathological study

Identifying memory impairment and early dementia in primary care

Prediction of Free and Cued Selective Reminding Test Performance Using Volumetric and Amyloid-Based Biomarkers of Alzheimer’s Disease

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