Abstract:e21083 Background: Dacomitinib showed superior efficacy for patients with epidermal growth factor receptor (EGFR) sensitive mutations as compared to that of gefitinib, especially for those harboring exon 21 L858R mutation. However, the grade 3-4 treatment related adverse events were more common in patients receiving 45mg of dacomitinib as initial treatment. Hence, we did this study to explore efficacy and safety of low dose dacomitinib for first-line treatment of patients with EGFR exon 21 mutated non-small c… Show more
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