Initial load of hepatitis B virus (HBV), its changing profile, and precore/core promoter mutations correlate with the severity and outcome of acute HBV infection

Abstract

The rapid decrease in viral load in the early phase of acute HBV infection was associated with the severity of the disease. A high viral load on admission and the presence of both precore and core promoter mutations in patients with severe coagulopathy closely correlated with mortality.

Elevation of the Hepatitis B Virus DNA during the Treatment of Polycythemia Vera with the JAK Kinase Inhibitor Ruxolitinib

“…Borentain et al reported that the non-A phenotype of HBV virus and the existence of core and/or pre-core mutation of HBV gene were associated with tendency for the reactivation of HBV to occur (15). Furthermore, it was reported that core/pre-core mutation was associated with the severity of hepatitis (16). Altogether, it is suggested that ruxolitinib may carry a potential risk of triggering HBV reactivation.…”

Therapy of Acute and Fulminant Hepatitis B

“…In addition, factors associated with decreased or absent HBeAg expression might lead to more severe disease such as with viruses harboring basal core promotor and/or precore mutations [precore ( G1896A, G1899A ) , core promoter ( T1753A/C, T1754C/G, A1762T/G1764A )] [29]. In a small study among American Indians, alcohol abuse and methamphetamine abuse was associated with worse outcome [30].…”

Entecavir in Severe Acute Hepatitis B

“…For HBV infection, it has been reported that precore mutation, core promoter mutation, HBV genotype, and pretreatment HBV load are associated with the development of fulminant hepatitis [56] . Previous studies have proven that serum level of Total Bilirubin (TBiL), ratio of total to direct bilirubin, white blood cell count; hepatic coma grade, prothrombin time and age are important prognostic factors for patients with fulminant hepatic failure [57,58].…”

“…Sainokami et al [57] reported that in patients with fulminant hepatitis B, serum level of HBV DNA on admission was higher in patients who died than those who recovered. They further found that the rapid decrease in viral load in the early phase of acute HBV infection was associated with the severity of the disease if the patients did not receive antiviral therapy.…”