Initial host invasion of Colletotrichum gloeosporioides is dampened by 1-methylcyclopropene due to blocking ethylene sensitivity of the fungus

Active Discovery of the Allosteric Inhibitor Targeting Botrytis cinerea Chitinase Based on Neural Relational Inference for Food Preservation

“…Traditionally, the method of combatting postharvest gray mold heavily leans on chemical preservatives. − These preservatives, exemplified by traditional chemical compounds, demonstrate targeted activity against B. cinerea proteins, showcasing potent antifungal efficacy in inhibiting gray mold disease. Structural biology studies elucidate that these compounds intricately interact with the catalytic pocket of target proteins, categorizing them as typical competitive inhibitors. − This mechanism, while efficacious, subjects the pathogen’s microbial population to selective pressure . This prompts microbial strains to evade competition, leading to the elimination of less resistant strains, inducing alterations in the microbial community’s structure and dynamics.…”