Initial fetal platelet counts predict the response to intravenous gammaglobulin therapy in fetuses that are affected by PLA1 incompatibility

The maternal immune response to fetal platelet GPIbα causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies

“…FNIT is the most common type of severe thrombocytopenia in live-born neonates and carries a major risk of intracranial hemorrhage, which can lead to neurological impairment or death (5)(6)(7)(8). The incidence of FNIT has been estimated at 0.5-1.5 per 1,000 liveborn neonates (1)(2)(3)(4).…”

Peut-on prendre en charge l'allo-immunisation plaquettaire fœtomaternelle de manière non invasive? Expérience sur dix ans

“…En l'absence de traitement, le risque de récurrence est évalué entre 72 et 80 % en cas d'antécédent d'HIC alors qu'il est estimé à 7 % en l'absence d'antécédent d'HIC [18]. Alors que pour certains, la gravité est corrélée à l'existence d'un antécédent d'HIC anténatal [9,19], pour d'autres, elle est corrélée au taux de plaquettes lors de la première ponction [20,21]. Cependant, cette attitude implique une ponction de sang foetal systématique en cours de grossesse.…”

Reconsidering fetal and neonatal alloimmune thrombocytopenia with a focus on screening and prevention

“…In addition, it was found that 66% of the women who had given birth to newborns with platelet counts less than 20 × 10 9 /l (with or without postnatal ICH) had fetuses with severe thrombocytopenia in a subsequent pregnancy. In contrast to this, Gaddipati et al found no relationship between obstetric history and sibling fetal platelet count in a retrospective study of 74 cases [46]. Data analyses that only included prospective cases gave a positive predictive value for obstetric history of 41% [11].…”

“…Among siblings with severe FNAIT and no ICH (defined as a platelet count of <20 or 50 × 10 9 /l), data are still unclear, ranging from no relationship to a 66% recurrence rate [11,[45][46][47].…”