Initial fate assessment of teratogenic drug trimipramine and its photo-transformation products – Role of pH, concentration and temperature

Khaleel, Nareman Dahshan Henedaq; Olsson, Oliver; Kümmerer, Klaus

doi:10.1016/j.watres.2016.10.078

Cited by 14 publications

(6 citation statements)

References 29 publications

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“…UV irradiation alone, whether UVA, UVB, or UVC, has proven itself to be a suitable technique for water decontamination when polluted by antidepressants or their derivatives [60]. UVC treatment has been most effective, as shown by recent studies of photo-degradation of tricyclic antidepressants like AMI and CLO [61] or TRI [62] in water with efficiencies above 90%, while the combination of UVA + UVB applied to DES in water yielded a very long half-life of 36 hours [63] and UVA irradiation alone was only able to degrade less than 30-40% of both DOX and VEN even after 114 days of irradiation [64]. The performance of the latter was only improved significantly when used in combination with a photocatalyst, TiO 2 , or with Fe 2+ and H 2 O 2 , i.e.…”

Section: Advanced Oxidation Processes (Aops)mentioning

confidence: 99%

Wastewater Treatment Approaches for the Removal of Antidepressant Residues

C. Racovita,

D. Ciuca

2024

Wastewater Treatment - Past and Future Perspectives [Working Title]

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Pharmaceuticals are a major class of contaminants of emerging concern for wastewaters and natural waters alike. Among pharmaceuticals, antidepressants are the most rapidly increasing subclass, as more and more people are dealing with depression in their fast-paced and challenging everyday lives. As psychotropic medications, residual antidepressants in water must be carefully monitored and maintained below levels, where human health may be endangered. Moreover, aquatic life forms were shown to be seriously affected when such pollutants entered their natural habitat, in terms of locomotory, reproductive functions, or social behavior. Therefore, modern wastewater treatment plant technologies should incorporate solutions for removing antidepressant residues. This chapter summarizes recent efforts toward this goal and covers a wide range of proposed treatment approaches. Firstly, adsorptive methods are presented, whether based on classic, yet effective adsorbents like activated carbon or silicates, or modern alternatives such as ion-exchange resins or molecularly imprinted polymers. Secondly, extractive methods are considered, although currently impractical due to lack of both cheap and environmentally-benign solvents. Thirdly, advanced oxidation processes are surveyed, including ozone treatment, ultraviolet, gamma radiation, and electrochemical options, some of which, alone or in combination, may yield complete mineralization of antidepressant toxicants. Lastly, biological treatment with microorganisms is discussed, which may be highly specific, but usually does not enable a complete mineralization.

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Section: Advanced Oxidation Processes (Aops)mentioning

confidence: 99%

Wastewater Treatment Approaches for the Removal of Antidepressant Residues

C. Racovita,

D. Ciuca

2024

Wastewater Treatment - Past and Future Perspectives [Working Title]

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“…The pH of a drug's environment can alter its bioavailability while also affecting its degradation rate. Hydrolysis is highly dependent on the pH of the medium, with ester hydrolysis being more pronounced in acidic conditions and amide hydrolysis being favored under alkaline conditions [85]. Understanding the pH-dependent reactivity of drug functional groups is critical for designing stable drug formulations that maintain efficacy under various physiological conditions.…”

Section: Factors Influencing Drug Degradationmentioning

confidence: 99%

“…Quality control is an integral part of ensuring the safety and efficacy of antidepressant drugs, and it involves quality control procedures throughout the manufacturing process, from raw material selection to the final product release [31,85]. Quality control measures include rigorous testing of raw materials, in-process testing during manufacturing, and finished product testing [56].…”

Section: Regulatory Considerations and Quality Controlmentioning

confidence: 99%

An Overview of Degradation Strategies for Amitriptyline

Comanescu,

Racovita

2024

IJMS

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Antidepressant drugs play a crucial role in the treatment of mental health disorders, but their efficacy and safety can be compromised by drug degradation. Recent reports point to several drugs found in concentrations ranging from the limit of detection (LOD) to hundreds of ng/L in wastewater plants around the globe; hence, antidepressants can be considered emerging pollutants with potential consequences for human health and wellbeing. Understanding and implementing effective degradation strategies are essential not only to ensure the stability and potency of these medications but also for their safe disposal in line with current environment remediation goals. This review provides an overview of degradation pathways for amitriptyline, a typical tricyclic antidepressant drug, by exploring chemical routes such as oxidation, hydrolysis, and photodegradation. Connex issues such as stability-enhancing approaches through formulation and packaging considerations, regulatory guidelines, and quality control measures are also briefly noted. Specific case studies of amitriptyline degradation pathways forecast the future perspectives and challenges in this field, helping researchers and pharmaceutical manufacturers to provide guidelines for the most effective degradation pathways employed for minimal environmental impact.

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“…by oxidative treatment do not have a better biodegradability than their parent compounds but may even be recalcitrant too (e.g. Khaleel et al, 2017;Herrmann et al, 2015;Rastogi et al, 2014Rastogi et al, , 2015aRastogi et al, , 2015b. Other studies even demonstrated that biodegradation of photo TPs led to the generation of new, recalcitrant bio-TPs (Herrmann et al, 2016b;Gutowski et al, 2015).…”

Section: Advanced Treatmentmentioning

confidence: 99%

Reducing aquatic micropollutants – Increasing the focus on input prevention and integrated emission management

Kümmerer

Dionysiou

Olsson

et al. 2019

Science of The Total Environment

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Pharmaceuticals and many other chemicals are an important basis for nearly all sectors including for example, food and agriculture, medicine, plastics, electronics, transport, communication, and many other products used nowadays. This comes along with a tremendous chemicalization of the globe, including ubiquitous presence of products of chemical and pharmaceutical industries in the aquatic environment. Use of these products will increase with population growth and living standard as will the need for clean water. In addition, climate change will exacerbate availability of water in sufficient quantity and quality. Since its implementation, conventional wastewater treatment has increasingly contributed to environmental protection and health of humans. However, with the increasing pollution of water by chemicals, conventional treatment turned out to be insufficient. It was also found that advanced effluent treatment methods such as extended filtration, the sorption to activated charcoal or advanced oxidation methods have their own limitations. These are, for example, increased demand for energy and hazardous chemicals, incomplete or even no removal of pollutants, the generation of unwanted products from parent compounds (transformation products, TPs) of often-unknown chemical structure, fate and toxicity. In many countries, effluent treatment is available only rarely if at all let alone advanced treatment. The past should teach us, that focusing only on technological approaches is not constructive for a sustainable water quality control. Therefore, in addition to conventional and advanced treatment optimization more emphasis on input prevention is urgently needed, including more and better control of what is present in the source

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Initial fate assessment of teratogenic drug trimipramine and its photo-transformation products – Role of pH, concentration and temperature

Cited by 14 publications

References 29 publications

Wastewater Treatment Approaches for the Removal of Antidepressant Residues

Wastewater Treatment Approaches for the Removal of Antidepressant Residues

An Overview of Degradation Strategies for Amitriptyline

Reducing aquatic micropollutants – Increasing the focus on input prevention and integrated emission management

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