Initial experience with X-ray ct based attenuation correction in myocardial perfusion spect imaging using a combined spect/ct system

Utsunomiya, Daisuke; Tomiguchi, Seiji; Shiraishi, Shinya; Yamada, Kazuo; Honda, Tsuyoshi; Kawanaka, Koichi; Kojima, Akira; Awai, Kazuo; Yamashita, Yasuyuki

doi:10.1007/bf02985576

Cited by 54 publications

(33 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…10,11 Recently, another attenuation correction method has been suggested. 12 The former utilizes electrocardiography to improve the specificity of myocardial imaging, whereas the latter uses tomography images for this purpose. To our knowledge, the present study is the first suggesting that adverse attenuation could be predicted by measuring breast thickness and tissue Hounsfield density.…”

Section: Discussionmentioning

confidence: 99%

Predicting Breast Attenuation in Patients Undergoing Myocardial Perfusion Scintigraphy: A Digital X-Ray Study

et al. 2007

View full text Add to dashboard Cite

Attenuation artifacts are the most common sources of error in myocardial single-photon emission computed tomography (SPECT) imaging. Breast artifacts are the most frequent causes of false positive planar images in female subjects. The purpose of this study was to predict breast adverse attenuation by measuring breast tissue thickness with digital x-ray. Sixty-five consecutive female patients with angina pectoris, who were referred to myocardial perfusion scintigraphy were enrolled in this study. Eighteen patients with normal perfusion imaging and normal coronary angiography composed the first group, whereas the second group consisted of 28 patients with a positive exercise electrocardiogram with anterior ischemia on myocardial perfusion imaging and greater than 50% left anterior descending artery stenosis on angiography. Nineteen patients in the third group had normal exercise electrocardiograms and normal coronary angiographies, but anterior ischemia on perfusion imaging. Digital x-ray records were obtained for measuring breast tissue thickness and Hounsfield density. The rate of breast adverse attenuation was 40% (19/47) in patients with anterior ischemia. The sensitivity and specificity of the prediction of breast adverse attenuation (lateral density less than 550 Hounsfield) were 79% and 11%, respectively. When breast attenuation for a breast thickness greater than 6 cm measured in the left anterior oblique view was predicted, the sensitivity and specificity were 79% and 93%, respectively. In conclusion, breast thickness greater than 6 cm measured from the left anterior oblique view with digital x-ray can predict breast adverse attenuation in female patients, and thereby may decrease the number of unnecessary invasive diagnostic procedures to be performed.

show abstract

Section: Discussionmentioning

confidence: 99%

Predicting Breast Attenuation in Patients Undergoing Myocardial Perfusion Scintigraphy: A Digital X-Ray Study

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Attenuation correction (AC) with X-ray computed tomography (CT) has been sought after for reducing attenuation artifacts [1][2][3][4][5][6][7][8]. The diagnostic accuracy for detection of coronary artery disease will be increased when a myocardial perfusion SPECT (MPS) image is attenuation corrected using patient-specific non-uniform attenuation coefficient maps.…”

Section: Introductionmentioning

confidence: 99%

Attenuation correction of myocardial SPECT by scatter-photopeak window method in normal subjects

et al. 2009

View full text Add to dashboard Cite

Objective: Segmentation with scatter and photopeak window data using attenuation correction (SSPAC) method can provide a patient-specific non-uniform attenuation coefficient map only by using photopeak and scatter images without X-ray computed tomography (CT). The purpose of this study is to evaluate the performance of attenuation correction (AC) by the SSPAC method on normal myocardial perfusion database. Methods:A total of 32 sets of exercise-rest myocardial images with Tc-99m-sestamibi were acquired in both photopeak (140keV±10%) and scatter (7% of lower side of the photopeak window) energy windows. Myocardial perfusion databases by the SSPAC method and non-AC (NC) were created from 15 female and 17 male subjects with low likelihood of cardiac disease using quantitative perfusion SPECT software (QPS). Segmental myocardial counts of a 17-segment model from these databases were compared on the basis of paired T test . Results: AC average myocardial perfusion count was significantly higher than that in NC in the septal and inferior regions (P<0.02). On the contrary, AC average count was significantly lower in the anterolateral and apical regions (P<0.01). Coefficient variation (CV) of the AC count in the mid, apical and apex regions was lower than that of NC. Conclusions: The SSPAC method can improve average myocardial perfusion uptake in the septal and inferior regions and provide uniform distribution of myocardial perfusion. The SSPAC method could be a practical method of attenuation correction without X-ray CT.

show abstract

“…Further, SPECT suffers from poor resolution 5 due to the effect of collimator blurring. In addition, their diagnostic and quantitative accuracies are affected by photon attenuation and scatter in the body 6,7 . Without proper attenuation and scatter correction, tumors located at different depths will show different radiotracer uptakes, leading to significant errors in diagnosis, internal dosimetry calculations, tumor staging, radiotherapy planning, and treatment evaluation.…”

Section: Introductionmentioning

confidence: 99%

“…As CT images contain detailed anatomical information, SPECT-CT fu-sion can provide localization information useful for the interpretation of SPECT data. Moreover, because CT measures tissue density distribution, the registered CT images can be converted into attenuation maps and be used for attenuation and scatter correction of the SPECT data 5,6 . Lastly, by incorporating information from the registered CT image into the SPECT reconstruction procedure, we may also improve the spatial resolution of SPECT 8,9 .…”

Section: Introductionmentioning

confidence: 99%

Dual-isotope Acquisition for CT–SPECT Registration of Infection Studies

2009

View full text Add to dashboard Cite

The registration of CT and NM images can enhance patient diagnosis since it allows for the fusion of anatomical and functional information as well as attenuation correction of NM images. However, irrespective of the methods used, registration accuracy depends heavily on the characteristics of the input images and the degree of similarity between them. This poses a challenge for registering CT and NM images as they may have very different characteristics. To address the particular problem of CT and In-111 SPECT registration, we propose to perform a dual-isotope study which involves an additional injection of Tc-99m MDP to generate two inherently registered images: In-111 SPECT and Tc-99m SPECT. As skeletal structures are visible in both CT and Tc-99m SPECT, performing registration of these images may be much more effective. The very same spatial transformation derived can be immediately applied to complete the registration of CT and the corresponding In-111 SPECT. Accordingly, we hypothesize that the registration of CT and Tc-99m SPECT can be more accurately performed than the registration of CT and In-111 SPECT and seek to compare the accuracies between the aforementioned registrations. In this paper, we have collected three clinical datasets, with the ground-truth transformations known, and tested the proposed approach by using a mutual information-based algorithm to solve for the rigid/non-rigid misalignments introduced to them. Based on the results of our experiments, we conclude that registration using Tc-99m SPECT can achieve 100% success rate, and is thus much more superior to the registration using In-111 SPECT, which at best, achieves only 38% success rate. Clearly, the introduction of a dual-isotope acquisition can substantially improve the registration of SPECT and CT images.

show abstract

Initial experience with X-ray ct based attenuation correction in myocardial perfusion spect imaging using a combined spect/ct system

Abstract: Because of an increase in the specificity, diagnostic accuracy was significantly increased on AC-images. These preliminary data suggest that X-ray CT based AC in myocardial SPECT imaging has the potential to develop into a reliable clinical technique.

Cited by 54 publications

References 15 publications

Predicting Breast Attenuation in Patients Undergoing Myocardial Perfusion Scintigraphy: A Digital X-Ray Study

Predicting Breast Attenuation in Patients Undergoing Myocardial Perfusion Scintigraphy: A Digital X-Ray Study

Attenuation correction of myocardial SPECT by scatter-photopeak window method in normal subjects

Dual-isotope Acquisition for CT–SPECT Registration of Infection Studies

Contact Info

Product

Resources

About