Initial experience with ultrasound localization for positioning prostate cancer patients for external beam radiotherapy

Serago, Christopher F.; Chungbin, Suzanne; Buskirk, Steven J.; Ezzell, Gary A.; Collie, Alex; Vora, Sujay A.

doi:10.1016/s0360-3016(02)02826-2

Cited by 148 publications

(81 citation statements)

References 22 publications

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“…[6][7][8][9] In the current study, using more sophisticated anthropometric measures of abdominal obesity than previous EBRT studies and treating patients with IGRT techniques, we were unable to show that obesity or a specific fat distribution predisposes towards a higher risk of biochemical failure. This was true at least in patients with intermediate-risk disease, despite the fact that ultrasonographic prostate localization could be limited by its poor image quality in obese patients 31 and its accuracy compared with implanted fiducial markers is questioned. 32 Nevertheless, the use of the ultrasound localization of the prostate can increase the precision in dose delivery when compared with patient setups with conventional bony matching.…”

Section: à2mentioning

confidence: 99%

Prognostic impact of abdominal adiposity, waist circumference and body mass index in patients with intermediate-risk prostate cancer treated with radiotherapy

Zilli

Nguyễn

et al. 2011

Int J Obes

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Objective: We tested the potential role of abdominal visceral (VAT) and subcutaneous (SAT) adipose tissues, waist circumference (WC) and body mass index (BMI) as prognostic factors in patients with intermediate-risk prostate cancer (clinical stage T1b-2b, and Gleason Score (GS) ¼ 7 and prostate-specific antigen PSA level o15 ng ml À1 , or GS p6 and PSA between 10 and 20 ng ml À1 ) treated with ultrasound-based image-guided radiotherapy. Methods: VAT, SAT and WC (measured from planning abdominal computed tomography) and BMI were compared with clinical and pathologic factors using univariate analyses. Cox regression analyses were performed to evaluate whether obesity indices significantly predicted biochemical disease free-survival (bDFS). Results: Of the 112 eligible patients, 30 (27%) were obese. Median BMI at baseline was 27.5 kg m À2 (range, 19.2-51.5 kg m À2 ). Greater abdominal adiposity, WC and BMI were significantly associated with younger age at diagnosis and increased prostate volume (P ¼ 0.003 and P ¼ 0.002, respectively). No significant correlation between obesity measures and T-stage, GS, PSA or percentage of positive cores at biopsy was found. On Cox regression analyses, none of the obesity measures predicted for bDFS. No association was observed between obesity indices and surrogate markers of biochemical failure as PSA nadir (nPSA) or time to nPSA. Conclusions: Abdominal adiposity, WC and BMI are associated with younger age at diagnosis and greater prostate volume but not with an increased risk of biochemical failure in patients with intermediate-risk prostate cancer.

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Section: à2mentioning

confidence: 99%

Prognostic impact of abdominal adiposity, waist circumference and body mass index in patients with intermediate-risk prostate cancer treated with radiotherapy

Zilli

Nguyễn

et al. 2011

Int J Obes

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“…The use of ultrasound in imaging the prostate has been studied but its value remains controversial. (4,5,6,7,8,9,10). The issues yet to be clarified are the differences between the ultrasound image and the CT image in determining the prostate anatomy and the possibility that the pressure of the probe shifts the prostate position between alignment and treatment.…”

Section: Introductionmentioning

confidence: 99%

A Comparison of the Use of Bony Anatomy and Internal Markers for Offline Verification and an Evaluation of the Potential Benefit of Online and Offline Verification Protocols for Prostate Radiotherapy

McNair

Hansen

Parker

et al. 2008

International Journal of Radiation Oncology*Biology*Physics

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“…Various approaches have been used to reduce these uncertainties including daily imaging prior to treatment using abdominal ultrasound ( 3 – 9 ) and CT scans, ( 10 – 12 ) immobilization devices (13) (i.e., rectal balloon), and placement of fiducial markers ( 7 , 8 , 14 – 18 ) in the prostate gland. Unfortunately, the majority of the data with these devices are in the definitive setting where the target or prostate is well visualized.…”

Section: Introductionmentioning

confidence: 99%

Target localization for post‐prostatectomy patients using CT and ultrasound image guidance

Paskalev

Feigenberg

Jacob

et al. 2005

J Applied Clin Med Phys

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We conducted a study comparing B‐mode acquisition and targeting (BAT) ultrasound alignments based on CT data in the postoperative setting. CT scans were obtained with a Primatom CT‐on‐rails on nine patients. Two CT scans were obtained each week, while setup error was minimized by BAT ultrasounds. For the first three patients, a direct comparison was performed. For the next six patients, a template based on the shifts from the week 1 CT during treatment was used for subsequent setup. Comparison of isocenter shifts between the BAT ultrasound and CT was made by the difference, absolute difference, and improvement (using CT alignments as the reference technique). A total of 90 image comparisons were made. The average interfraction motion was 3.2 mm in the lateral, 3.0 mm in the longitudinal, and 5.1 mm in the AP direction. The results suggest that the CT‐based ultrasound templates can improve the localization of the prostate bed when the initial displacements are greater than 4 mm. For initial displacements smaller than 4 mm, the technique neither improved nor worsened target localization. However, ultrasound alignments performed without the use of a template deteriorated patient positioning for two out of three patients, demonstrating that the use of a CT template was beneficial even at small initial displacements.PACS numbers: 87.53.‐j, 87.53.Kn, 87.53.Xd

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Initial experience with ultrasound localization for positioning prostate cancer patients for external beam radiotherapy

Cited by 148 publications

References 22 publications

Prognostic impact of abdominal adiposity, waist circumference and body mass index in patients with intermediate-risk prostate cancer treated with radiotherapy

Prognostic impact of abdominal adiposity, waist circumference and body mass index in patients with intermediate-risk prostate cancer treated with radiotherapy

A Comparison of the Use of Bony Anatomy and Internal Markers for Offline Verification and an Evaluation of the Potential Benefit of Online and Offline Verification Protocols for Prostate Radiotherapy

Target localization for post‐prostatectomy patients using CT and ultrasound image guidance

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