Initial experience with SPECT examinations using [123I]IBZM as a D2-dopamine receptor antagonist in Parkinson's disease

Cordes, Michael; Henkes, Hans; Laudahn, D.; Bräu, H.; Kramp, W.; Girke, Wolfgang; Hierholzer, J.; Eichstädt, H.; Félix, R.

doi:10.1016/0720-048x(91)90069-8

Cited by 19 publications

(6 citation statements)

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“…A postsynaptic striatal deficiency can be also demonstrated by means of specific radioligands that focus on D 2∕3 striatal dopamine receptors. 123 I-Iodobenzamide ( 123 I-IBZM) SPECT, 11 C-Raclopride PET and 18 F-Desmethoxyfallypride ( 18 F-DMFP) PET have suggested for this purpose (Cordes et al, 1991 ; Antonini et al, 1997 ; Stark et al, 2007 ; Vernaleken et al, 2007 ). In addition, the latter was recently used to separate idiopathic and non-idiopathic parkinsonian syndromes with high accuracy (la Fougère et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

“…A substantial part of multivariate methods are based on machine learning algorithms such as decision trees (Quinlan, 1986 ) or support vector machine (SVM; Vapnik, 1999 ). They have been successfully used to assist the diagnosis of Parkinsonism using different neuroimage modalities (Cordes et al, 1991 ; Dodel et al, 2003 ; Illán et al, 2012 ; Segovia et al, 2012 ; Nair et al, 2013 ; Mudali et al, 2015 ). Bayesian approaches (Ben-Gal, 2008 ) were also used for this purpose.…”

Section: Introductionmentioning

confidence: 99%

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Distinguishing Parkinson's disease from atypical parkinsonian syndromes using PET data and a computer system based on support vector machines and Bayesian networks

Segovia

Illán

Górriz

et al. 2015

Front. Comput. Neurosci.

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Differentiating between Parkinson's disease (PD) and atypical parkinsonian syndromes (APS) is still a challenge, specially at early stages when the patients show similar symptoms. During last years, several computer systems have been proposed in order to improve the diagnosis of PD, but their accuracy is still limited. In this work we demonstrate a full automatic computer system to assist the diagnosis of PD using 18F-DMFP PET data. First, a few regions of interest are selected by means of a two-sample t-test. The accuracy of the selected regions to separate PD from APS patients is then computed using a support vector machine classifier. The accuracy values are finally used to train a Bayesian network that can be used to predict the class of new unseen data. This methodology was evaluated using a database with 87 neuroimages, achieving accuracy rates over 78%. A fair comparison with other similar approaches is also provided.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Distinguishing Parkinson's disease from atypical parkinsonian syndromes using PET data and a computer system based on support vector machines and Bayesian networks

Segovia

Illán

Górriz

et al. 2015

Front. Comput. Neurosci.

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“…Bei der visuellen Auswertung zeigten alle unbehandelten Patienten eine SD MED RANGE M W SD MED RANGE BG48/FC48 1,37 0,09 1,36 1,53--1,22 1,08 0,08 1,1 1,28--0,97 BG80/FC48 1,33 0,09 1,33 1,5 --1,2 1,07 0,08 1,08 1,27--0,97 BG120/FC48 1,29 0,09 1,29 1,46--1,15 1,07 0,07 1,07 1,25--0,97 mBG/FC48 1,34 0,1 1,33 1,54--1,18 1,07 0,07 1,07 1,24--0,97 99%IC/FC48 1,46 0,11 1,47 1,63--1,25 1,07 0,07 1, (4,8,18). Es konnte gezeigt werden, daß es anschließend für einen Zeitraum von bis zu 3 h p. i. zu keiner (2,4,12) oder nur einer geringfügigen Abnahme (18) der Striatalen IBZM-Anreicherung kommt.…”

Section: Ergebnisseunclassified

Hirn-SPECT mit 123J-markiertem Iodobenzamid (IBZM): Aspekte der semiquantitativen Auswertung

Menzel¹,

Grünwald²,

Klemm³

et al. 1993

Nuklearmedizin

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ZusammenfassungDie striatale Dopamin-D2-Rezeptoranreicherung von 123J-IBZM wurde bei 32 Patienten (18 ohne und 14 mit neuroleptischer Therapie) semiquantitativ unter Anwendung verschiedener ROI-Techniken ausgewertet. Ziel der Studie war es, die von verschiedenen Untersuchern gefundenen unterschiedlichen Quotienten (Striatum/Kortex) unter dem Aspekt der angewandten ROI-Technik zu untersuchen. Es konnte gezeigt werden, daß bei Verwendung des gleichen SPECT-Systems keine größeren Unterschiede zwischen Rechteck-ROI und manuell erstellten ROI gleicher Größe auftreten. Eine hochsignifikante Trennung zwischen behandelten und unbehandelten Patienten ergab sich für alle untersuchten Auswerteverfahren. Der ermittelte Quotient wird wesentlich durch das Auflösungsvermögen der Kamera und nur relativ geringfügig durch die verwendete ROI-Technik bestimmt. Die Quotienten verschiedener Arbeitsgruppen sind quantitativ nicht miteinander vergleichbar.

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“…The 70 to 90 minutes interval is selected because highest striatal uptake of IBZM has been reported over such a time period in men (Cordes et al, 1991), and the time-activity 'plateau' (Briicke et al, 1991a) resembles that of [llC]raclopride, another benzamide used for PET imaging (Farde et al, 1986). Among the different camera systems available for SPECT, the double-head rotating gamma camera or the three-he~ded rotating scintillation camera equipped with medi am energy collimators is normally used.…”

Section: Introductionmentioning

confidence: 99%

IBZM-SPECT imaging of dopamine D₂ receptors with typical and atypical antipsychotics

et al. 1998

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Considerable progress has been achieved over the past 15 years in uncovering the biological basis of major psychiatric disorders. Since psychopharmacological treatment is thought tc act on the underlying biological basis of the disease, brain imaging techniques enable us to understand the mechanism of action of such compounds. One important tool used to determine patterns of brain dysfunction and how psychopharmacological agents such as antipsychotic compounds work is single-photon emission computerised tomography (SPECT). This technique allows determination of striatal D(2) receptor occupancy rates, which are associated with the extrapyramidal side effects (EPS) of antipsychotic drugs. Studies have confirmed that atypical antipsychotic agents have lower occupancy rates than typical agents. No association has been found between D(2) receptor occupancy rates n the striatum and antipsychotic efficacy, and it therefore appears that striatal D(2) receptor occupancy rates are not necessary for the antipsychotic effect of such agents in schizophrenia. The availability of more refined radioligands will help us not only to understand the action of antipsychotics but also the pathophysiology of schizophrenia.

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Initial experience with SPECT examinations using [123I]IBZM as a D2-dopamine receptor antagonist in Parkinson's disease

Cited by 19 publications

References 5 publications

Distinguishing Parkinson's disease from atypical parkinsonian syndromes using PET data and a computer system based on support vector machines and Bayesian networks

Distinguishing Parkinson's disease from atypical parkinsonian syndromes using PET data and a computer system based on support vector machines and Bayesian networks

Hirn-SPECT mit 123J-markiertem Iodobenzamid (IBZM): Aspekte der semiquantitativen Auswertung

IBZM-SPECT imaging of dopamine D₂ receptors with typical and atypical antipsychotics

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Initial experience with SPECT examinations using [123I]IBZM as a D2-dopamine receptor antagonist in Parkinson's disease

Cited by 19 publications

References 5 publications

Distinguishing Parkinson's disease from atypical parkinsonian syndromes using PET data and a computer system based on support vector machines and Bayesian networks

Distinguishing Parkinson's disease from atypical parkinsonian syndromes using PET data and a computer system based on support vector machines and Bayesian networks

Hirn-SPECT mit 123J-markiertem Iodobenzamid (IBZM): Aspekte der semiquantitativen Auswertung

IBZM-SPECT imaging of dopamine D2 receptors with typical and atypical antipsychotics

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IBZM-SPECT imaging of dopamine D₂ receptors with typical and atypical antipsychotics