Initial experience with radiofrequency ablation for hepatic tumours in the Netherlands

Mutsaerts, Eduard L. A. R.; Coevorden, Frits van; Krause, Raymond J.; Rinkes, Inne H.M. Borel; Strobbe, Luc J. A.; Prevoo, Warner; Tollenaar, R.A.E.M.; Gulik, Thomas M. van

doi:10.1016/s0748-7983(03)00146-x

Cited by 19 publications

(8 citation statements)

References 22 publications

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“…Radiofrequency ablation (RFA) is a fairly new technique that can be used for nodules up to 4 cm in diameter in the treatment of unresectable primary and secondary hepatic tumors [71]. The complication rate is 5%-10%, and the mortality rate is low, with a reduction in complications with increasing experience with this technique [72].…”

Section: Radiofrequency Ablationmentioning

confidence: 99%

Metastatic Carcinoid Tumors: A Clinical Review

2005

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Carcinoid tumors are neuroendocrine tumors derived from enterochromaffin cells, which are widely distributed in the body. They can originate from any location in the body, but they are traditionally described as originating from the foregut, midgut, and hindgut. Although the overall incidence of carcinoid tumors appears to have increased in the past decades, the prognosis for patients with metastatic carcinoid tumors has improved during the last decade. Due to longer survival times, complications, such as carcinoid heart disease, and new metastatic patterns, like skin and bone metastases, may become more important features of carcinoid disease. Therapy focused on these complications should be part of the management. Combining new diagnostic and treatment modalities in metastatic carcinoid patients may result in better quality of life and longer survival times. The increasing number of therapeutic options and diagnostic procedures requires a multidisciplinary approach, with decisions made in multidisciplinary meetings focused on "tailor-made" therapy based on patients' specific conditions. Because carcinoid tumors are uncommon, effort should be made to treat these patients in specialized centers and for these centers to join together in multicenter studies. The Oncologist 2005;10:123-131The Oncologist 2005;10:123-131 www.TheOncologist.com

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Section: Radiofrequency Ablationmentioning

confidence: 99%

Metastatic Carcinoid Tumors: A Clinical Review

2005

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“…In both techniques, heat is generated leading to local tumour destruction with only minimal concomitant damage to the surrounding liver parenchyma. RFA and LITT are considered relatively safe techniques with the ability to accomplish local disease control [4,5,6,7]. Published long-term results after RFA and interstitial laser coagulation (ILC) seem to be promising with 5-year survival rates ranging from 30 to 40% and 15 to 35%, respectively [7,8,9,10,11,12,13,14].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Viable Tumour Tissue Attached to Needle Applicators after Local Ablation of Liver Tumours

et al. 2009

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Aim: Local recurrence and needle track seeding are serious complications after local ablation for liver malignancies and potentially affect long-term survival. The aim of this study was to assess the incidence of viable tissue adherent to the needle applicators after ablation to gain insight into the possible mechanisms of local recurrence and needle track seeding. Methods: A total of 40 consecutive patients underwent 59 local liver ablations. Cells and tissue attached to the needle applicators were analysed for morphology (HE, PAP and Giemsa staining) and viability (G6PD staining). Results: Macroscopic tissue adherence was visible following 31 of the ablative procedures, all with radiofrequency ablation. Four applications were performed percutaneously and 27 during an open procedure. Morphologically intact tumour cells could be identified in 8 patients (20%), and viable tumour cells in 5 patients (12.5%). Morphologically intact tumour cells or viable tumour cells could only be demonstrated when track ablation was not performed. Conclusion: Viable tumour cells adherent to the needle applicators were found in an alarming 12.5% of patients after local ablation. We recommend track ablation not only after the procedure but also during any shifting and (re-)positioning to prevent shedding of viable tumour cells during or after ablation.

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“…Initial experience with the technique was described in 50 patients, mainly with colorectal liver metastases [21]. Eleven tumours (7 patients) were resected after prior treatment with RFA ablation.…”

Section: Resultsmentioning

confidence: 99%

Radiofrequency for the Treatment of Liver Tumours

2005

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Resection should still be considered the gold standard for many liver tumours. There is, however, growing interest in the use of radiofrequency (RFA) for the treatment of liver tumours. By RFA, tumour tissue can be destructed selectively without significant damage to vascular structures in the remaining liver. The technique is safe and feasible for many types of liver tumours. RFA appears to be beneficial in the treatment of hepatocellular carcinoma. In the Netherlands, single-centre reports suggest that RFA may be used successfully to control hepatocellular carcinoma in those patients awaiting liver transplantation. RFA is being increasingly used for colorectal liver metastases as an adjunct to surgical resection in case of unresectable lesions. However, to date, there are still no data showing that such an approach is beneficial. For this reason, in the Netherlands, RFA for unresectable colorectal liver metastases is mainly used within a clinical trial. Within the multimodality treatment of neuroendocrine metastases, RFA may deserve a place for either intention to cure (rare) or debulking with the aim of reduction of symptoms or prolongation of life.

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Initial experience with radiofrequency ablation for hepatic tumours in the Netherlands

Cited by 19 publications

References 22 publications

Metastatic Carcinoid Tumors: A Clinical Review

Metastatic Carcinoid Tumors: A Clinical Review

Assessment of Viable Tumour Tissue Attached to Needle Applicators after Local Ablation of Liver Tumours

Radiofrequency for the Treatment of Liver Tumours

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