Initial experience with carboplatin desensitization: A case series in a paediatric hospital

Río, Pablo Rodríguez del; Andión, Maitane; Ruano, David; Escudero, Carmelo; Méndez‐Brea, Paula; Sánchez‐García, Silvia; Ibáñez, María Dolores

doi:10.1111/pai.12816

Cited by 8 publications

(2 citation statements)

References 15 publications

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“…It is claimed that the drugs used may conceal the early signs of HSR 5,13 . Although there are premedication protocols that differ depending on the drug that is desensitized in various studies, 14‐17 we preferred to use a standard protocol in our patients. In some patients, the premedication protocol was modified in the event of a breakthrough reaction.…”

Section: Discussionmentioning

confidence: 99%

Safety and efficacy of rapid drug desensitization in children

Esenboğa

Akarsu

Ocak

et al. 2022

Pediatric Allergy Immunology

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Background: Any drug taken at the recommended dosage may cause hypersensitivity reactions (DHR). Rapid drug desensitization (RDD) protocols have been developed in the case of a confirmed or highly suspected HSR to allow safe administration of the medicine when there is no alternative drug or in the presence of a less effective or more toxic alternative. The aim of this study was to evaluate the characteristics of children who underwent desensitization, the safety and efficacy of RDD in children, as well as, the characteristics and management of breakthrough reactions.Method: This retrospective study concerned children who underwent RDD due to physician-diagnosed HSRs during or up to 48 hours after the infusion of various drugs between February 2010-February 2021. Patients with a chronic disease needing chronic drug usage and acute infections seen in patients with chronic diseases were included. The results of RDD were documented. Results:The study included 48 patients [8.1(IQR = 3.32-13.4) years, 60.4% male] with 58 HSRs of which 62.1% were classified as moderate and 5.2% as severe. Most of the patients were being treated for leukemia (41.7%), solid tumors (29.2%), and infections (6.3%). Skin tests were done for 41 out of 58 HSRs in 35 patients, and twenty of them were positive. A total of 269 RDDs were performed for 18 different drugs. Ninety percent of desensitizations were achieved with no reaction, and 3.7% and 5.6% with mild and moderate reactions, respectively. In multivariate analysis, skin test positivity was the only risk factor for breakthrough reactions (OR = 8.5, CI = 1.72-42.15, p = .009). Conclusion:We demonstrated the safety and efficacy of RDD in childhood, thereby offered the first line treatment options to children with chronic diseases with hypersensitivity reactions (HSRs).

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Section: Discussionmentioning

confidence: 99%

Safety and efficacy of rapid drug desensitization in children

Esenboğa

Akarsu

Ocak

et al. 2022

Pediatric Allergy Immunology

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“…Desensitization might be an option, but little experience exists in pediatric patients. Here, the authors describe a protocol for desensitization, which showed to be safe and efficient …”

Section: Drug Allergymentioning

confidence: 99%

Food and drug allergy, and anaphylaxis in EAACI journals (2018)

Eigenmann

Akdiş²,

Bousquet

et al. 2019

Pediatric Allergy Immunology

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The European Academy of Allergy and Clinical Immunology (EAACI) supports three journals: "Allergy," "Pediatric Allergy and Immunology (PAI)," and "Clinical and Translational Allergy (CTA)." One of the major goals of EAACI is to support health promotion in which prevention of allergy and asthma plays a critical role and to disseminate the knowledge of allergy to all stakeholders including the EAACI junior members. This paper summarizes the achievements of 2018 in anaphylaxis, and food and drug allergy. Main topics that have been focused are anaphylaxis, mechanisms of food allergy (FA), epidemiology of FA, food allergens, diagnosis of FA, prevention and control of FA, FA immunotherapy, drug allergy, and political agenda. K E Y W O R D S allergy, anaphylaxis, Clinical and Translational Allergy, drug allergy, European Academy of Allergy and Clinical Immunology, food allergy, hypersensitivity, Pediatric Allergy and Immunology

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Successful immunosuppressive drug‐free immune tolerance induction in hemophilia B with inhibitor and anaphylaxis to factor IX: A case report

Palomo Bravo,

Prieto Bonilla,

Bardan Rebollar

et al. 2024

Clinical Case Reports

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Key Clinical MessageRecommendations advise factor IX desensitization before immune tolerance induction in severe hemophilia B, supported by immunosuppression. A child with inhibitor and anaphylaxis to factor IX showed successful immunosuppression‐free immune tolerance induction using very low and slowly increasing doses of a factor IX extended‐half‐life product. Immune tolerance to factor IX based on this protocol merits further study.

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Initial experience with carboplatin desensitization: A case series in a paediatric hospital

Cited by 8 publications

References 15 publications

Safety and efficacy of rapid drug desensitization in children

Safety and efficacy of rapid drug desensitization in children

Food and drug allergy, and anaphylaxis in EAACI journals (2018)

Successful immunosuppressive drug‐free immune tolerance induction in hemophilia B with inhibitor and anaphylaxis to factor IX: A case report

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