2002
DOI: 10.1097/00006231-200202000-00003
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Initial evaluation of the feasibility of single photon emission tomography with p-[123I]iodo-L-phenylalanine for routine brain tumour imaging

Abstract: p-[123I]iodo-L-phenylalanine (IPA) is a recently described radiopharmaceutical which is highly accumulated in gliomas. The present investigation was designed to evaluate the feasibility of single photon emission tomography (SPET) with IPA to image brain tumours under routine clinical conditions. Using a dual- and a triple-headed SPET camera, whole-body kinetic and brain SPET, as well as plasma, urinary and dosimetric analysis were determined in four patients with gliomas after intravenous injection of IPA. Res… Show more

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Cited by 25 publications
(23 citation statements)
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“…Moreover, previous investigations of 131 I-IPA monotherapy found no histomorphologic abnormalities in the liver, kidneys, and thyroid of treated animals, and no rat had clinical signs of malfunction of any organ (24). Additionally, prior biodistribution studies and radiation dose estimates based on studies in animals and humans revealed that 123 I-IPA-131 I-IPA is exclusively eliminated by urine, and the highest absorbed doses were determined in the urinary bladder wall and in the kidneys (18,21,37,38). Radioactivity accumulation in bone marrow, the urogenital system, and the thyroid gland is rather tolerably low.…”
Section: Discussionmentioning
confidence: 99%
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“…Moreover, previous investigations of 131 I-IPA monotherapy found no histomorphologic abnormalities in the liver, kidneys, and thyroid of treated animals, and no rat had clinical signs of malfunction of any organ (24). Additionally, prior biodistribution studies and radiation dose estimates based on studies in animals and humans revealed that 123 I-IPA-131 I-IPA is exclusively eliminated by urine, and the highest absorbed doses were determined in the urinary bladder wall and in the kidneys (18,21,37,38). Radioactivity accumulation in bone marrow, the urogenital system, and the thyroid gland is rather tolerably low.…”
Section: Discussionmentioning
confidence: 99%
“…The iodinated amino acids p-123 I-iodo-L-phenylalanine ( 123 I-IPA) and p-124 I-iodo-L-phenylalanine have been used clinically for this purpose (18)(19)(20). Both these phenylalanine derivatives actively cross the blood-brain barrier after intravenous administration and accumulate specifically in gliomas, presumably via the amino acid transporters L and ASC (system ASC amino acid transporter for neutral amino acids), which are overexpressed in malignant glioma cells (21)(22)(23).…”
mentioning
confidence: 99%
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“…System L is active at the blood–brain barrier (BBB) which is desirable for imaging gliomas and other brain tumors with relatively intact BBBs that are not visualized using contrast enhancement on CT or MRI. 3133 A number of amino acid based system L substrates have been developed including O -(2-[ 18 F]fluoroethyl)- l -tyrosine (FET), 12–15 6-[ 18 F]fluoro-3,4-dihydroxy- l -phenylalanine (FDOPA), 16,17 3-[( 123 )I]iodo- l - α -methyltyrosine (IMT), 34 and 4-[ 123/124/131 I]iodo- l -phenylalanine (IPA), 3537 all of which have been used for imaging of gliomas. In addition to providing distinct metabolic information, these amino acids have less uptake in the normal brain and inflammatory tissues compared to [ 18 F]FDG.…”
Section: Introductionmentioning
confidence: 99%
“…Concerning the development of new g-emitting tracers it has to be mentioned that the novel radiocompound p-123 I-iodo-L-phenylalanine has been proposed to investigate low-grade and high-grade glioma [16], although data on recurrence are not still available.…”
mentioning
confidence: 99%