Initial Clinical Testing of a Holographic Non-Invasive Contact Lens Glucose Sensor

Domschke, Angelika; March, Wayne F.; Kabilan, Satyamoorthy; Lowe, Christopher R.

doi:10.1089/dia.2006.8.89

Cited by 70 publications

(41 citation statements)

References 13 publications

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“…Boronic acid derivatives have also been used in holographic contact lens glucose sensors. Boronic acid within a polymer binds glucose, swelling the polymer and altering the colour of light reflected by the holographic element of the contact lens [63]. For potential analyte detection methods, human tissue has intrinsic fluorescence at specific wavelengths [64].…”

Section: Fluorescencementioning

confidence: 99%

Glucose sensors: a review of current and emerging technology

et al. 2009

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Glucose monitoring technology has been used in the management of diabetes for three decades. Traditional devices use enzymatic methods to measure glucose concentration and provide point sample information. More recently continuous glucose monitoring devices have become available providing more detailed data on glucose excursions. In future applications the continuous glucose sensor may become a critical component of the closed loop insulin delivery system and, as such, must be selective, rapid, predictable and acceptable for continuous patient use. Many potential sensing modalities are being pursued including optical and transdermal techniques. This review aims to summarize existing technology, the methods for assessing glucose sensing devices and provide an overview of emergent sensing modalities.

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Section: Fluorescencementioning

confidence: 99%

Glucose sensors: a review of current and emerging technology

et al. 2009

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“…The boronic acid group, which is in its sp 2 hybridized trigonal form, turns into a more electron-rich sp 3 hybridized, tetrahedral geometry upon interaction with glucose, thereby leading to changes in the spectra of the fluorescent moiety. 44,45 Nonfluorophore-based optical detection of glucose utilizes light of variable frequencies to investigate changes in the absorbance, reflection, or refraction (scattering) of tissue containing various concentrations of glucose. 33,34 In particular, light with wavelengths in the near-infrared (NIR) range have been found to pass through the human stratum corneum with minimal tissue absorption.…”

Section: Glucose Detection Based On Optical Approachesmentioning

confidence: 99%

Technologies for Continuous Glucose Monitoring: Current Problems and Future Promises

Vaddiraju

Burgess

Tomazos

et al. 2010

J Diabetes Sci Technol

229

224

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Devices for continuous glucose monitoring (CGM) are currently a major focus of research in the area of diabetes management. It is envisioned that such devices will have the ability to alert a diabetes patient (or the parent or medical care giver of a diabetes patient) of impending hypoglycemic/hyperglycemic events and thereby enable the patient to avoid extreme hypoglycemic/hyperglycemic excursions as well as minimize deviations outside the normal glucose range, thus preventing both life-threatening events and the debilitating complications associated with diabetes. It is anticipated that CGM devices will utilize constant feedback of analytical information from a glucose sensor to activate an insulin delivery pump, thereby ultimately realizing the concept of an artificial pancreas. Depending on whether the CGM device penetrates/breaks the skin and/or the sample is measured extracorporeally, these devices can be categorized as totally invasive, minimally invasive, and noninvasive. In addition, CGM devices are further classified according to the transduction mechanisms used for glucose sensing (i.e., electrochemical, optical, and piezoelectric). However, at present, most of these technologies are plagued by a variety of issues that affect their accuracy and long-term performance. This article presents a critical comparison of existing CGM technologies, highlighting critical issues of device accuracy, foreign body response, calibration, and miniaturization. An outlook on future developments with an emphasis on long-term reliability and performance is also presented.

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“…К этим молекулам присоединяют флюо-ресцентные группы, что обусловливает возмож-ность их спектроскопического определения. При взаимодействии с глюкозой группа бороновой кис-лоты, имеющая sp2-гибридизованную тригональ-ную конфигурацию, принимает более насыщенную электронами sp3-гибридизованную тетраэдриче-скую форму, что вызывает изменение эмиссионного спектра флюоресцентного фрагмента [26].…”

Section: рис 3 оптическая детекция глюкозы (адаптировано из [17])unclassified

Continuous glucose monitoring technologies: state of the art and future perspectives in view of artificial pancreas

Владимирович¹,

Иванович²,

Андреевна³

et al. 2015

Probl Endokrinol (Mosk)

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Continuous glucose monitoring (CGM) - a relatively new and rapidly developing technology of optimization glycemic control in patients with diabetes. The efficiency of the use of CGM for improving glycemic level in many clinical situations (asymptomatic hypoglycemia, high blood glucose variability, etc.). In the long term, CGM treated as a mandatory component of the «artificial pancreas» - an insulin pump with a closed-loop control infusion of insulin depending on the concentration of glucose in the blood. However, the modern technology such as CGM could not be used, as a data source to control closed-loop insulin pump (artificial pancreas), because of the significant limitations and lack of precision. In further development of technologies CGM, obviously, will address three main objectives: increased service life of sensors for the detection of glucose, improving the accuracy of measurement results and ease of use for patients. This article describes the main technological solutions of modern devices for CGM and promising directions for further developments in this field, their potential advantages and disadvantages, including in the light of the prospects for further integrating them into an «artificial pancreas».

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Initial Clinical Testing of a Holographic Non-Invasive Contact Lens Glucose Sensor

Abstract: The holographic contact lens glucose sensor shows promise as a non-invasive home glucose monitor.

Cited by 70 publications

References 13 publications

Glucose sensors: a review of current and emerging technology

Glucose sensors: a review of current and emerging technology

Technologies for Continuous Glucose Monitoring: Current Problems and Future Promises

Continuous glucose monitoring technologies: state of the art and future perspectives in view of artificial pancreas

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