Initial clinical results of the bioartificial kidney containing human cells in ICU patients with acute renal failure

Humes, H. David; Weitzel, William F.; Bartlett, Robert H.; Swaniker, Fresca; Paganini, Emil P.; Luderer, John R.; Sobota, J

doi:10.1111/j.1523-1755.2004.00923.x

Cited by 225 publications

(158 citation statements)

References 32 publications

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“…Preliminary results suggest that this device may replace some of the metabolic, endocrine, and immunologic function in sepsis-associated AKI while potentially modifying its natural history (132,133). Results of a phase III trial that has stopped enrollment are not yet available.…”

Section: Ebp Limitations and Future Innovationsmentioning

confidence: 99%

Potential Interventions in Sepsis-Related Acute Kidney Injury

Ronco¹,

Kellum²,

Bellomo³

et al. 2008

Clinical Journal of the American Society of Nephrology

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Sepsis is an important cause of morbidity and mortality. Acute kidney injury often complicates sepsis, leading to greater complexity, cost of care, and worsening prognosis. In recent years, a consensus definition of acute kidney injury has been developed, facilitating research into the pathophysiology and epidemiology of this disorder. New and emerging biomarkers to recognize kidney injury before functional abnormalities are manifest may allow early recognition and facilitate prevention or treatment. Furthermore, advances in the clinical management of sepsis may have secondary benefits with respect to renal outcomes. Existing and hybrid extracorporeal therapies are being investigated not only as means to replace lost kidney function but also to modulate the immune response to sepsis. For those who have more advanced forms of kidney injury, strategies to promote renal recovery are being sought to minimize the long-term consequences of impaired kidney function. This review provides an update on the current state of the science and a glimpse toward the future of intervention in sepsis-related acute kidney injury.

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Section: Ebp Limitations and Future Innovationsmentioning

confidence: 99%

Potential Interventions in Sepsis-Related Acute Kidney Injury

Ronco¹,

Kellum²,

Bellomo³

et al. 2008

Clinical Journal of the American Society of Nephrology

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“…150,155 This more "complete" renal replacement was felt to be safe 151 and to convey 180 day survival and return of renal function benefits to a small group of ICU patients enrolled in an open-label trial for CVVH with RAD augmentation. 156 Phase III trials have not been published but are planned according to the authors.…”

Section: Acknowledgementsmentioning

confidence: 99%

“…Whole organ procurement in the lab setting is reported from porcine kidneys 150 and human kidneys procured but unsuitable for transplantation. 151 Investigational cell lines have been utilized, specifically MadinDarby canine kidney (MDCK) cells and Lewis lung cancerporcine kidney 1 (LLC-PK 1 ) cells. 152,153 Renal tubule cells are cultured on an ultrastructure, typically an existing hollow fiber membrane or a newer engineered membrane.…”

Section: O N O T D I S T R I B U T Ementioning

confidence: 99%

Renal replacement therapy review

Fleming

2011

Organogenesis

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“…Initially, these two units were used in concert. More recently, the production of a RAD with human cells has been completed successfully and used on humans in an extracorporeal setting (84,85). Here, conventional dialysis was combined with a RAD that contained 10 9 human renal proximal tubular cells that were harvested from donated human kidneys (85).…”

Section: Bioartificial Glomeruli and Renal Tubulesmentioning

confidence: 99%

Regrow or Repair

Little

2006

Journal of the American Society of Nephrology

153

121

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Regenerative medicine is being heralded in a similar way as gene therapy was some 15 yr ago. It is an area of intense excitement and potential, as well as myth and disinformation. However, with the increasing rate of end-stage renal failure and limited alternatives for its treatment, we must begin to investigate seriously potential regenerative approaches for the kidney. This review defines which regenerative options there might be for renal disease, summarizes the progress that has been made to date, and investigates some of the unique obstacles to such treatments that the kidney presents. The options discussed include in situ organ repair via bone marrow recruitment or dedifferentiation; ex vivo stem cell therapies, including both autologous and nonautologous options; and bioengineering approaches for the creation of a replacement organ.

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Initial clinical results of the bioartificial kidney containing human cells in ICU patients with acute renal failure

Cited by 225 publications

References 32 publications

Potential Interventions in Sepsis-Related Acute Kidney Injury

Potential Interventions in Sepsis-Related Acute Kidney Injury

Renal replacement therapy review

Regrow or Repair

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