Initial clinical evaluation of stationary digital chest tomosynthesis

Hartman, Allison; Shan, Jing; Wu, Gongting; Lee, Yueh Z.; Zhou, Otto; Lu, Jianping; Heath, Michael D.; Wang, Xiaohui; Foos, David H.

doi:10.1117/12.2216850

Cited by 3 publications

(10 citation statements)

References 30 publications

(29 reference statements)

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“…The measured focal spot size is 2.5 mm by 0.5 mm. [13,14] The flat panel silicon detector is 35 cm by 43 cm with a 139 mm pixel size and acquisition time of 5 fps. The system resolution was 1.7 cycles/mm in scan direction and 3.4 cycles/mm in the perpendicular direction.…”

Section: S-dct and Chest Radiography Imaging Systemsmentioning

confidence: 99%

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Initial clinical evaluation of stationary digital chest tomosynthesis in adult patients with cystic fibrosis

et al. 2018

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Section: S-dct and Chest Radiography Imaging Systemsmentioning

confidence: 99%

“…The entrance dose for adult patients was 0.6 mGy. [14] Conventional chest radiography was performed on a Fuji machine with a Siemens digital detector. Clinically acquired upright PA images used for the study were acquired with a typical source to detector distance of 182 cm and automatic exposure.…”

Section: S-dct and Chest Radiography Imaging Systemsmentioning

confidence: 99%

Initial clinical evaluation of stationary digital chest tomosynthesis in adult patients with cystic fibrosis

et al. 2018

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“…As such, an X‐ray source consisting of a linear array of CNT cathodes provides an ideal platform to address the source blur, patient motion, and angle span limits affecting the performance of rotational gantry DT systems. CNT‐enabled linear source arrays have been incorporated into existing breast tomo and chest X‐ray (CXR) devices, replacing their original thermionic sources. These experimental devices have been termed stationary digital breast and chest tomo (sDBT or sDCT).…”

Section: Cnt‐enabled Clinical Imaging: Stationary Digital Tomosynthesismentioning

confidence: 99%

“…6 However, at this time, the only extensive clinical experience with CNT-enabled imaging has involved stationary tomosynthesis, a technology made possible by distributing and coordinating multiple CNT-enabled sources in a single Xray tube (Figure 1). In fact, to date, over 100 patients have been studied with these devices on Institutional Review Board (IRB)-approved protocols for breast, 21 lung, 22 and dental imaging. 23…”

Section: Field Emission and The Cnt Cathodementioning

confidence: 99%

An update on carbon nanotube‐enabled X‐ray sources for biomedical imaging

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Hartman

et al. 2017

WIREs Nanomed Nanobiotechnol

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A new imaging technology has emerged that uses carbon nanotubes (CNT) as the electron emitter (cathode) for the X-ray tube. Since the performance of the CNT cathode is controlled by simple voltage manipulation, CNT-enabled X-ray sources are ideal for the repetitive imaging steps needed to capture threedimensional information. As such, they have allowed the development of a gated micro-computed tomography (CT) scanner for small animal research as well as stationary tomosynthesis, an experimental technology for large field-of-view human imaging. The small animal CT can acquire images at specific points in the respiratory and cardiac cycles. Longitudinal imaging therefore becomes possible and has been applied to many research questions, ranging from tumor response to the noninvasive assessment of cardiac output. Digital tomosynthesis (DT) is a low-dose and low-cost human imaging tool that captures some depth information. Known as three-dimensional mammography, DT is now used clinically for breast imaging. However, the resolution of currently-approved DT is limited by the need to swing the X-ray source through space to collect a series of projection views. An array of fixed and distributed CNT-enabled sources provides the solution and has been used to construct stationary DT devices for breast, lung, and dental imaging. To date, over 100 patients have been imaged on Institutional Review Board-approved study protocols. Early experience is promising, showing an excellent conspicuity of soft-tissue features, while also highlighting technical and post-acquisition processing limitations that are guiding continued research and development. Additionally, CNT-enabled sources are being tested in miniature X-ray tubes that are capable of generating adequate photon energies and tube currents for clinical imaging. Although there are many potential applications for these small field-of-view devices, initial experience has been with an X-ray source that can be inserted into the mouth for dental imaging. Conceived less than 20 years ago, CNT-enabled X-ray sources are now being manufactured on a commercial scale and are powering both research tools and experimental human imaging devices.

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“…X-ray devices for breast, chest, and dental imaging have been developed with CNT technology and are being tested in Institutional Review Board-approved studies. [18][19][20] To date, most clinical experience with 3-D CE breast imaging has been with gadolinium-enhanced MR. 21 However, given the high cost and limited availability of MR compared with radiation-based imaging, research continues into the development of CE DBT. For radiation-based techniques, such as DBT, iodine is the contrast agent of choice.…”

Section: Introductionmentioning

confidence: 99%

Phantom-based study exploring the effects of different scatter correction approaches on the reconstructed images generated by contrast-enhanced stationary digital breast tomosynthesis

et al. 2018

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Stationary digital breast tomosynthesis (sDBT) is an emerging technology in which the single rotating x-ray tube is replaced by a fixed array of multiple carbon nanotube-enabled sources, providing a higher spatial and temporal resolution. As such, sDBT offers a promising platform for contrast-enhanced (CE) imaging. However, given the minimal enhancement above background with standard operational tube settings and iodine dosing, CE breast imaging requires additional acquisition steps to isolate the iodine signal, using either temporal or dual energy subtraction (TS or DES) protocols. Also, correcting for factors that limit contrast is critical, and scatter and noise pose unique challenges during tomosynthesis. This phantom-based study of CE sDBT compared different postacquisition scatter correction approaches on the quality of the reconstructed image slices. Beam-pass collimation was used to sample scatter indirectly, from which an interpolated scatter map was obtained for each projection image. Scatter-corrected projections provided the information for reconstruction. Comparison between the application of different scatter maps demonstrated the significant effect that processing has on the contrast-to-noise ratio and feature detectability ([Formula: see text]) in the final displayed images and emphasized the critical importance of scatter correction during DES.

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Initial clinical evaluation of stationary digital chest tomosynthesis

Cited by 3 publications

References 30 publications

Initial clinical evaluation of stationary digital chest tomosynthesis in adult patients with cystic fibrosis

Initial clinical evaluation of stationary digital chest tomosynthesis in adult patients with cystic fibrosis

An update on carbon nanotube‐enabled X‐ray sources for biomedical imaging

Phantom-based study exploring the effects of different scatter correction approaches on the reconstructed images generated by contrast-enhanced stationary digital breast tomosynthesis

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