Initial Characterization of the Dosimetry and Radiobiology of a Device for Administering Interstitial Stereotactic Radiosurgery

Hakim, Rodolfo; Zervas, Nicholas T.; Hakim, Fernando; Butler, William E.; Beatty, J.; Yanch, J. C.; Biggs, Peter J.; Gall, Kenneth P.; Sliski, Alan

doi:10.1227/00006123-199703000-00016

Cited by 4 publications

(5 citation statements)

References 9 publications

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“…For the irradiation experiments, cell monolayers grown in 35/ 10 mm dishes were exposed to low energy photon radiation delivered by the Photon Radiosurgery System (PRS; Photoelectron Corp., Lexington, MA). Radiation properties of this miniature X-ray device for interstitial radiotherapy are described elsewhere [15,16]. A single dose of 9, 18, or 25 Gray was delivered at a rate of 1.4 Gray/min at room temperature.…”

Section: Cell Culture and Irradiation Proceduresmentioning

confidence: 99%

“…In such high, single-dose irradiation, interphase cell death is presumed to play a role in tumor cell killing, although details of the process remain unknown. Therefore, using a well characterized radio-resistant brain tumor model of 9L Gliosarcoma [12 ± 14], we sought to characterize the acute cell death after a large dose, single irradiation utilizing the Photon Radiosurgery System (PRS), a recently developed apparatus allowing easy-to-handle intra-operative interstitial irradiation [15,16]. Specifically, we asked what proportion of the irradiated cells undergo rapid interphase cell death, and whether those cells undergo apoptotic cell death or show characteristics of necrotic cell death.…”

Section: Introductionmentioning

confidence: 99%

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Early Effects of PRS-Irradiation for 9L Gliosarcoma: Characterization of Interphase Cell Death

Kurita¹,

Ostertag²,

Baumer³

et al. 2000

Minim Invasive Neurosurg

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We characterized the interphase cell death of 9L gliosarcoma after high-dose-rate, low-energy photon irradiation using the Photon Radiosurgery System (PRS), a novel device for interstitial radiotherapy. Within 24 hours after irradiation with a dose of 18 Gray, 22.0% of cells underwent metabolic cell death, whereas dead cells in controls stayed less than 5.0% (p<0.005). In the majority of sensitive cells, loss of membrane integrity preceded the lethal morphological changes. The response was dose-dependent over the range of 9-18 Gray, but saturation was obtained over 18 Gray. On the other hand, a significant (p < 0.01) increase in the number of TUNEL-positive cells with apoptotic morphology was detected 6-24 hours after irradiation, but the fraction remained 1.9-2.1% of the population and was independent of the doses between 9 and 25 Gray. Apoptotic cells were rarely observed in the control cells (0.3-0.6%). Our data indicate that single high-dose irradiation induces both necrotic and apoptotic interphase cell death in 9L gliosarcoma, but rapid cell death mostly occurs through the non-apoptotic pathway.

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Section: Cell Culture and Irradiation Proceduresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Early Effects of PRS-Irradiation for 9L Gliosarcoma: Characterization of Interphase Cell Death

Kurita¹,

Ostertag²,

Baumer³

et al. 2000

Minim Invasive Neurosurg

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“…In the USA, the device has received approval from the Food and Drug Administration for use at any body site. It has a number of potential applications, and although it has mainly been studied as a neuro‐oncological treatment, it seems ideally suited for therapy of breast cancer 11−17 . A series of applicators of varying diameters are available, which allows the correct size to be chosen for any surgical cavity after breast conservation surgery.…”

Section: Introductionmentioning

confidence: 99%

Prospective trial of intraoperative radiation treatment for breast cancer

Joseph

Bydder

Jackson

et al. 2004

ANZ Journal of Surgery

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This simple and well-tolerated treatment delivers a useful radiation dose to the area of highest risk of tumour recurrence. The early infection rate is similar to that reported in the literature, for treatments without intraoperative radiotherapy. Whether such a treatment may adequately replace the entire adjuvant radiation therapy treatment for low-risk patients is now being studied in a randomized trial.

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“…In fact, very small errors in defining, for instance, the penumbra of the beams could impair some applications of SRS (Cheung et al 1998, Dawson et al 1984, Sibata et al 1991. In many cases, dose measurements are performed without full lateral electronic equilibrium, thus inducing uncertainties in the dose measurement (Beddar et al 1994, Dutreix et al 1965, Hakim et al 1997, Luxton et al 1993, Rice et al 1987.…”

Section: Introductionmentioning

confidence: 99%

Dosimetry of Gamma Knife and linac-based radiosurgery using radiochromic and diode detectors

Somigliana

Cattaneo²,

Fiorino³

et al. 1999

Phys. Med. Biol.

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In stereotactic radiosurgery the choice of appropriate detectors, whether for absolute or relative dosimetry, is very important due to the steep dose gradient and the incomplete lateral electronic equilibrium. For both linac-based and Leksell Gamma Knife radiosurgery units, we tested the use of calibrated radiochromic film to measure absolute doses and relative dose distributions. In addition a small diode was used to estimate the relative output factors. The data obtained using radiochromic and diode detectors were compared with measurements performed with other conventional methods of dosimetry, with calculated values by treatment planning systems and with data prestored in the treatment planning system supplied by the Leksell Gamma Knife (LGK) vendor. Two stereotactic radiosurgery techniques were considered: Leksell Gamma Knife (using gamma-rays from 60Co) and linac-based radiosurgery (LR) (6 MV x-rays). Different detectors were used for both relative and absolute dosimetry: relative output factors (OFs) were estimated by using radiochromic and radiographic films and a small diode; relative dose distributions in the axial and coronal planes of a spherical polystyrene phantom were measured using radiochromic film and calculated by two different treatment planning systems (TPSs). The absolute dose at the sphere centre was measured by radiochromic film and a small ionization chamber. An accurate selection of radiochromic film was made: samples of unexposed film showing a percentage standard deviation of less than 3% were used for relative dose profiles, and for absolute dose and OF evaluations this value was reduced to 1.5%. Moreover a proper calibration curve was made for each set of measurements. With regard to absolute doses, the results obtained with the ionization chamber are in good correlation with radiochromic film-generated data, for both LGK and LR, showing a dose difference of less than 1%. The output factor evaluations, performed using different methods, are in good agreement with a maximum difference of 1.5% for all field sizes considered (LGK and LR) except the 4 mm helmet used in the LGK unit. In this case, differences exist between diode and radiochromic film measurements and both detectors show data values larger than the prestored OF value of 0.80. Dose profiles measured by radiochromic film and calculated are in excellent agreement for both LGK and LR with a maximum deviation of less than 1.0 mm, when full widths of the dose profiles at 20%, 50%, 80% levels are considered. When external photon beams are used in stereotactic radiosurgery, the 'well selected' radiochromic films are very accurate detectors both for relative and absolute dosimetry. The experimental results, obtained using both radiochromic and diode detectors, show that the 4 mm helmet relative output factor could be underestimated.

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Initial Characterization of the Dosimetry and Radiobiology of a Device for Administering Interstitial Stereotactic Radiosurgery

Cited by 4 publications

References 9 publications

Early Effects of PRS-Irradiation for 9L Gliosarcoma: Characterization of Interphase Cell Death

Early Effects of PRS-Irradiation for 9L Gliosarcoma: Characterization of Interphase Cell Death

Prospective trial of intraoperative radiation treatment for breast cancer

Dosimetry of Gamma Knife and linac-based radiosurgery using radiochromic and diode detectors

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